Medicinal composition for treating diabetic encephalopathy as well as preparation method and application thereof
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A technology for diabetic encephalopathy and a composition is applied in the field of pharmaceutical compositions for the treatment of diabetic encephalopathy, and can solve problems such as ununification and the like
Active Publication Date: 2015-08-26
CHENGDU HUASUN GRP INC LTD
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[0004] Diabetic encephalopathy is characterized by cognitive dysfunction, accompanied by a complication of structural and pathophysiological changes in the brain; some scholars have also proposed to name it "diabetes-related cognitive decline", which has not yet been unified
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Embodiment 1
[0049] The preparation of embodiment 1 pharmaceutical suspension oral liquid of the present invention
[0051] The experiment used water decoction, Pueraria 12g Coptidis 6g Scutellaria baicalensis 9g Dendrobium 12g was decocted in water and concentrated to a solution of 0.65g / ml, adding bear bile powder and Panax notoginseng powder to make a suspension.
Embodiment 2
[0052] The preparation of embodiment 2 pharmaceutical granules of the present invention
[0053] Take 12g of kudzu root, 6g of berberine, 9g of scutellaria baicalensis, 12g of dendrobium, 1.5g of bear bile, and 3g of notoginseng, extract according to the method in Example 1, concentrate, granulate, and granulate.
Embodiment 3
[0054] The preparation of embodiment 3 pharmaceutical capsules of the present invention
[0055] Pueraria 12g, Coptidis 6g, Scutellaria baicalensis 9g, Dendrobium 12g, bear bile 1.5g, Sanqi 3g were extracted according to the method of Example 1, concentrated, granulated, granulated, and packed into capsules.
[0056] Prove beneficial effect of the present invention by pharmacodynamic test below.
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Abstract
The invention provides a medicinal composition for treating diabetic encephalopathy. The medicinal composition is a preparation which is prepared from the following raw materials in parts by weight: 12-18 parts of kudzuvine root, 8-12 parts of coptis chinensis, 8-12 parts of scutellaria baicalensis, 12-18 parts of dendrobe, 2-4 parts of fel ursi and 2-4 parts of pseudo-ginseng. The invention also provides a preparation method and an application of the medicinal composition. The medicinal composition is remarkable in treatment effect on diabetic encephalopathy; the treatment effect of the medicinal composition is superior to cilostazol; and especially, the optimal treatment effect is achieved by a median dose group. The medicinal composition can be used for promoting angiogenesis by protecting capillaries which serve as blood brain barriers, improving the ischemia anaerobic condition of sea horses and regulating the activity of IGF-1 and PI3K / AKT / CREB signal channels of the sea horses.
Description
technical field [0001] The invention relates to a pharmaceutical composition for treating diabetic encephalopathy, which belongs to the field of medicines. Background technique [0002] Diabetes (diabetes mellitus, DM) and its complications have become a health issue of public concern, because in recent years, with social and economic development, global diabetes patients have surged far beyond people's expectations, according to statistics from the International Diabetes Federation (IDF) In 2011, the number of diabetic patients in the world was 370 million, and developing countries accounted for 80% of the cases. The prevalence of diabetes in people over 20 years old in my country reached 9.7%, and China has become the country with the largest number of diabetic patients. Diabetes has a long course of disease, many complications, and high medical costs, which have a great impact on patients and society. At present, non-infectious diseases such as diabetes, tumors, and cardi...
Claims
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