21results about How to "Regulatory activity" patented technology

The invention relates to a Fe monatomic nano-enzyme as well as a preparation method and application thereof. The preparation method of the Fe monatomic nano-enzyme comprises the following steps: dispersing poly-polyphenol spheres in water, adding ferric trichloride, stirring for 10-14 hours, centrifuging, drying, carbonizing, and pickling to obtain the Fe monatomic nano-enzyme. According to the Fe monatomic nano-enzyme as well as the preparation method and the application thereof, the poly polyphenol spheres and the ferric trichloride are taken as raw materials, the Fe monatomic nano-enzyme with different distances between adjacent active centers can be prepared, the preparation method is simple, the cost is low, and the reaction conditions are mild.

The invention relates to application of an NR1D1 gene in regulation and control of granular cells, and belongs to the technical field of biology. The invention provides an application of an NR1D1 gene in regulation and control of granulosa cells, including an application of a sequence shown in siRNA of the NR1D1 gene in preparation of a product for regulation and control of sheep granulosa cells, and the sequence is shown in SEQ ID NO: 1 and SEQ ID NO: 2. According to the regulation method and product of the granulosa cells, the proliferation apoptosis and activity of the granulosa cells can be effectively regulated, and the expression of follicular development related genes can be regulated. The method has the beneficial effects that in-vivo or in-vitro regulation and control effects on follicles and / or ovaries are realized, and a method and a product guarantee are provided for research on development and physiological and biochemical functions of granular cells, follicles and ovaries.

The invention discloses a recombinant XVII type collagen-thymosin beta4 fusion protein as well as a preparation method and application thereof, the recombinant XVII type collagen-thymosin beta4 fusion protein is a fragment of human XVII type collagen and a thymosin beta4 protein sequence, and the amino acid sequence of the recombinant XVII type collagen-thymosin beta4 fusion protein is shown as SEQ ID NO: 1. The recombinant XVII type collagen-thymosin beta4 fusion protein disclosed by the invention has good safety, can regulate and regulate intercellular signal transduction, and has good effects of promoting hair follicle cell proliferation and promoting hair regeneration.

The invention relates to the field of plant growth regulators, in particular to an ultramicro-granulated energy-gathered humic acid composite preparation which is prepared from the following raw materials in parts by weight: 50-80 parts of ultramicro-granulated energy-gathered humic acid, 10-30 parts of nanoscale metal oxide, 5-20 parts of a microbial agent, 1-10 parts of a plant growth regulator and 5-15 parts of a slow release agent. According to the invention, ultrafine particle shaped humic acid, nano-scale metal oxide, a microbial agent, a plant growth regulator and a slow-release agent are organically combined. The effect of the soil conditioner is far better than that of a single component or a traditional soil conditioner.

The invention provides a high-activity probiotic food for pets, which is characterized by comprising the following components in parts by weight: 88-93 parts of animal meat source, 8-12 parts of boneless chicken powder, 8-12 parts of fish protein powder, 10-15 parts of potato powder, 3-6 parts of beer yeast powder, 3-6 parts of compound probiotics, 0.8-1.2 parts of metabiotics and 3-6 parts of semen plantaginis. Wherein the compound probiotics are prepared by mixing bacillus subtilis SCS-06, the preservation number of which is CCTCC (China Center for Type Culture Collection) NO: M20211498 and bacillus licheniformis XCL-09, the preservation number of which is CCTCC NO: M20211497. The prepared probiotic grain contains rich nutrient substances, probiotics and traditional Chinese medicine active ingredients, the content of active bacteria in the product is high, and the probiotic grain has a remarkable enhancing effect on digestion promoting ability and immunity of intestinal tracts and is effectively proliferated to continuously protect the intestinal tracts.

The invention discloses a method for producing micromolecular organic acid and methane through anaerobic carbon metabolism based on selective release of endogenous electron shuttles of sludge and sludge deconstruction induced by ion exchange, and belongs to the field of sewage sludge resourceful treatment.The method comprises the steps that feeding sludge and an ion exchanger are evenly mixed in a closed carbon metabolism reactor, then the temperature is controlled to be 35-55 DEG C, and the temperature is controlled to be 35-55 DEG C; starting of carbon metabolism reaction is completed at the stirring speed gradient of 300-600 s <-1 >, in the stable period of the carbon metabolism reaction, a mixed system with the same volume is discharged and conveyed from the closed carbon metabolism reactor, and small-molecular organic acid and methane can be produced by regulating and controlling the adding amount of the ion exchanger, the retention time and the sludge load rate; when methane is recovered, methane is collected from a closed carbon metabolism reactor, PAC or FeCl3 is used for conditioning when small-molecular organic acid is recovered, then conditioning liquid is subjected to solid-liquid separation, obtained filtrate is recovered, obtained dehydrated filtrate is rich in small-molecular organic acid, and the whole-process efficiency of anaerobic carbon metabolism is enhanced.

The invention discloses application of 1, 4-dihydroxy-2-naphthoic acid in improvement of animal growth performance and intestinal health, and belongs to the technical field of feed additives. According to the invention, the 1, 4-dihydroxy-2-naphthoic acid is added into the basic feed, and tests prove that after the 1, 4-dihydroxy-2-naphthoic acid is added, the average daily gain and the average daily feed intake of broilers and piglets can be improved, and the feed conversion ratio is reduced; the piglet diarrhea can be improved, the development of the stomach and the small intestine of the piglet can be promoted, the morphological structure of the jejunum of the piglet can be improved, the development of the intestinal tract can be promoted, the activity of stem cells of the intestinal tract of the piglet can be regulated, and then the development of the gastrointestinal tract is promoted. Therefore, by adding the 1, 4-dihydroxy-2-naphthoic acid into the feed, the growth performance and the intestinal health of animals can be improved, the development of gastrointestinal tracts is promoted, the activity of the intestinal stem cells is regulated and controlled, and a new strategy is provided for improving the growth performance and the intestinal health of the animals.

The invention belongs to the field of pharmaceutical preparations. The invention relates to lipid nanoparticles modified by probiotic coupled galactose and coated with diammonium glycyrrhizinate, L-arginine and copper tannic acid nano enzyme as well as a preparation method and application of the lipid nanoparticles. The lipid nanoparticles prepared by coupling and wrapping the diammonium glycyrrhizinate, the L-arginine and the copper tannic acid nano-enzyme with the probiotics have good biocompatibility, the preparation method is simple, the particle size distribution of the nanoparticles is uniform, the half-life period of a medicine circulating in a body can be prolonged, the inherent beneficial functions of the probiotics are cooperated, and the bioavailability of the medicine is improved. The potential application value is realized in the fields of treating the metabolic dysfunction related steatohepatitis and the like.

The invention discloses a cobalt catalyst and a preparation method and application thereof. The structural formula of the cobalt catalyst is Co-Co3O4 (S)-coated NC-X, in the structural formula, S is the particle size of a cobalt active site, X is the pyrolysis temperature during preparation of the catalyst, and the microstructure of the cobalt catalyst is in a sphere-like shape sequentially comprising a cobalt core, cobaltosic oxide and a nitrogen-doped carbon shell from inside to outside. According to the invention, the catalyst is designed and prepared by using the cheap precursor, and the cobalt active sites are confined in the nitrogen-doped carbon shell, so that the agglomeration and loss of the cobalt active sites are effectively prevented, and the stability of the catalyst is improved. The cobalt catalyst can be used for synthesizing products of carbonyl compounds through selective catalytic oxidation with alcohol derivatives as substrates and air as an oxygen source, and has the advantages of being high in yield and efficient and green in reaction process.

The invention discloses a light conduction biological filler unit for water treatment, and relates to the technical field of sewage treatment.The light conduction biological filler unit comprises a light guiding component, a light shading component, light guiding components and biological attachments, the light shading component is installed at the bottom of the light guiding component, the light guiding components are arranged in the light shading component and inserted into water, and the biological attachments are arranged on the light guiding components. Biological attachments are attached to the surface of the light guide part, and the shading part is fixed to the water surface. According to the invention, light is input into water along with the light guide body, and the directions of nitrification and denitrification reactions are controlled by utilizing the promotion or inhibition effects of nitrifying bacteria and denitrifying bacteria under different illumination, so that the dependence on mechanical aeration is reduced, and pollutants in sewage are removed. Meanwhile, the thin optical fiber can also be used as a biological bed, photophilous microorganisms can grow on the surface of the optical fiber, and photosynthesis can also be realized in a deep water area in a biochemical pool, so that the removal rate of pollutants in sewage is further accelerated, the metabolic activity of algae can be improved, and an energy-saving effect is realized.

The invention discloses a system for synthesizing a catalyst for a silicon powder one-step method through a composite route and a method for preparing silicate ester through the silicon powder one-step method, the system comprises a plurality of liquid raw material storage tanks and a solid raw material storage tank, the liquid raw material storage tanks are used for storing a raw material solution or an azeotropic solvent, and the solid raw material storage tank is used for storing a powdery solid raw material; the bottoms of all the raw material storage tanks are connected with a feeding hole in the top of the reaction kettle through a discharging pipeline; the bottom of the reaction kettle is connected with a feeding hole of the finished product buffer tank through a pipeline; the bottom of the finished product buffer tank is connected with an application end through a pipeline; a mass flow meter is arranged on a discharge pipeline of each liquid raw material storage tank, and a mass sensor is arranged on each solid raw material storage tank; and each pipeline is provided with a valve. The catalyst preparation system and the methyl silicate production device are fused, so that the problems that the catalyst is easy to degrade and the production efficiency is low during long-distance transfer are solved. The activity regulation of the catalyst is realized, and different production requirements are met.

The application discloses a kind of adjustable defect sub-nanometer gold load nickel iron composite photoanode catalyst, preparation method and application, deionized water is introduced into nitrogen and is deoxidized, multi-walled carbon nanotube treated by strong acid is placed in deionized water after deoxidation, after ultrasonic dispersion is uniform, together with FeCl2, NiCl2, HMT and ammonium fluoride is added into reaction kettle, reaction is carried out at 120 DEG C for 6 hours, after cooling, it is taken out, using deionized water is filtered, washed after, HAuCl4 is quickly added, sealed and is stirred in dark room, after reaction is finished, it is filtered, washed, nitrogen is dried at room temperature and is preserved in oxygen-free atmosphere.The application is synthesized Au / NiFe (hydroxyl) oxide / CNT composite catalyst by in-situ oxidation technology one step.The method can be simultaneously controlled on the basis of heterojunction Defects, the synergistic effect of both makes the catalyst performance be further optimized.Synthesis method is simple and direct, and catalytic effect is obviously improved.

This invention provides a catalyst coated with a non-precious metal coating on a support and its preparation method. The invention also relates to the application of this non-precious metal coated-supported catalyst in the catalytic oxidation treatment of volatile organic compounds (VOCs). The catalyst of this invention has high mechanical strength, good coating wear resistance, and is not easily detached. Furthermore, the catalyst exhibits strong hydrothermal stability, good catalytic degradation performance of volatile organic compounds, and a long service life, making it particularly suitable for the treatment of VOCs containing sulfides.

This invention relates to novel compounds and their use as pharmaceuticals, more specifically for the prevention or treatment of diseases mediated by cGAS activity, particularly for the prevention or treatment of inflammatory conditions or cancer. The invention also relates to methods for preventing or treating said diseases, the methods comprising using the novel compounds. The invention further relates to pharmaceutical compositions or formulations of the novel compounds and their use as pharmaceuticals, more preferably for the prevention or treatment of diseases mediated by cGAS activity, particularly for the prevention or treatment of inflammatory conditions or cancer. The invention also relates to methods for preparing the compounds.

The invention provides inflammation response type bionic hydrogel as well as a preparation method and application thereof, and belongs to the field of biomedicine. The inflammation response type bionic hydrogel is prepared by taking a cross-linked polymer, hyaluronic acid, platelet lysate and nanoparticles as raw materials in an aqueous solution. The inflammation response type bionic hydrogel can be used as a stent for remodeling a pathological environment, converting an infarct part into a regeneration promoting state and promoting vascular regeneration so as to regulate and control survival and differentiation of neural stem cells and promote endogenous regeneration and repair, and has a good application prospect in treatment of ischemic stroke.

The invention discloses a chimeric antigen receptor as well as a carrier and an immune cell modified by the chimeric antigen receptor, the chimeric antigen receptor is IL2 signal-IL15-CD8a transmembrane-P2A-CD8a signal-scFv, and the chimeric antigen receptor is combined with another chimeric antigen receptor CD8a signal-GPC3 scFv-CD8a hinge-CD8a transmembrane-CD28-CD3 delta for use. The CAR modified immune cells express membrane type IL-15 and secrete and express'immune checkpoint molecule 'monoclonal antibodies. The co-expression of the cell factor IL-15 and the'immune checkpoint molecule 'monoclonal antibody not only prolongs the life cycle of the immune cells, but also prevents the inhibition signal channel of the immune checkpoint molecule by secreting and expressing the'immune checkpoint molecule' monoclonal antibody, so that the tumor cell killing effect of the immune cells is improved.

The invention discloses a diatom-doped carbon nitride composite catalyst and a preparation method and application thereof.The diatom-doped carbon nitride composite catalyst comprises a carbon nitride matrix, cobalt atoms and transition metal atoms, the cobalt atoms and the transition metal atoms are evenly embedded in the carbon nitride matrix, the cobalt atoms and the transition metal atoms are doped in carbon nitride, the synergistic effect of the catalyst is improved, and the catalytic activity of the catalyst is improved. Therefore, the activity and the stability of the catalyst are obviously improved; by adjusting the adding proportion of cobalt atoms and transition metal atoms, the activity of the catalyst can be effectively adjusted, so that the controllability of the catalyst is improved, and by efficiently activating peroxymonosulfate, the capacity of the catalyst for removing antibiotic pollutants in wastewater and sewage is remarkably improved; the method has the advantage of efficiently removing antibiotic pollutants in water, the preparation method is completed through a thermal polymerization method, and the method has the advantages of being low in cost, free of pollution and easy to operate and is suitable for large-scale production.

The invention discloses an alloy catalyst, a preparation method thereof and application of the alloy catalyst in low-temperature catalytic cracking of methane, and belongs to the technical field of catalysts for hydrogen production through methane cracking and preparation of the catalysts. The problems of low methane catalytic cracking efficiency and high catalytic reaction temperature in the prior art are solved. According to the Ni-Co-In alloy catalyst provided by the invention, the distribution of electrons around metal is changed by alloying nickel, cobalt and indium, so that the catalytic activity of the catalyst is improved. And the alloy catalyst contains a small number of elements, the proportion of the elements is easy to regulate and control, and the regulation and control of catalytic active sites and methane cracking catalytic performance of the alloy catalyst are realized by regulating and controlling the ratio of nickel, cobalt and indium elements in the alloy. Test results show that the methane conversion rate of the Ni < 0.65 > Co < 0.10 > In < 0.25 > alloy catalyst at the reaction temperature of 800 DEG C can reach 52%, and good stability is kept within 120 min of reaction.

The present disclosure relates to compounds of Formula (I): and prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods of their preparation. The compounds disclosed herein are useful for modulating DNA polymerase theta activity and for the treatment of conditions involving DNA polymerase theta activity, such as cancer.

The invention discloses a wood frog egg oil soft capsule for inhibiting premature ovarian failure and a preparation method thereof, the wood frog egg oil soft capsule comprises wood frog egg oil, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, dunaliella salina aqueous extract, silybum marianum seed oil, chitosan oligosaccharide and white peony root aqueous extract. The preparation method of the wood frog egg oil soft capsule comprises the following steps: uniformly mixing wood frog egg oil freeze-dried powder, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, dunaliella salina aqueous extract, silybum marianum seed oil, chitosan oligosaccharide and white peony root aqueous extract in parts by mass through superfine grinding to obtain a wood frog oil compound; the oviductus ranae compound is prepared into a capsule content, and the capsule content is filled into a capsule shell by a soft capsule machine to prepare the soft capsule. The oviductus ranae soft capsule is rich in various nutritional ingredients, has an excellent function of inhibiting premature ovarian failure of women through scientific compatibility, and can effectively activate the activity of ovarian cells and promote normal metabolism and function maintenance of the ovarian cells.

The application belongs to the technical field of biology and particularly relates to application of ISL2 in regulating melatonin synthesis. The application discloses that ISL2 can be combined with a melatonin synthesis rate-limiting enzyme AANAT gene promoter, so as to regulate activity of the AANAT promoter, further regulate an expression amount of AANAT, and finally realize regulation of melatonin synthesis.