11results about How to "Regulatory activity" patented technology

The invention relates to application of an NR1D1 gene in regulation and control of granular cells, and belongs to the technical field of biology. The invention provides an application of an NR1D1 gene in regulation and control of granulosa cells, including an application of a sequence shown in siRNA of the NR1D1 gene in preparation of a product for regulation and control of sheep granulosa cells, and the sequence is shown in SEQ ID NO: 1 and SEQ ID NO: 2. According to the regulation method and product of the granulosa cells, the proliferation apoptosis and activity of the granulosa cells can be effectively regulated, and the expression of follicular development related genes can be regulated. The method has the beneficial effects that in-vivo or in-vitro regulation and control effects on follicles and / or ovaries are realized, and a method and a product guarantee are provided for research on development and physiological and biochemical functions of granular cells, follicles and ovaries.

The invention relates to the field of plant growth regulators, in particular to an ultramicro-granulated energy-gathered humic acid composite preparation which is prepared from the following raw materials in parts by weight: 50-80 parts of ultramicro-granulated energy-gathered humic acid, 10-30 parts of nanoscale metal oxide, 5-20 parts of a microbial agent, 1-10 parts of a plant growth regulator and 5-15 parts of a slow release agent. According to the invention, ultrafine particle shaped humic acid, nano-scale metal oxide, a microbial agent, a plant growth regulator and a slow-release agent are organically combined. The effect of the soil conditioner is far better than that of a single component or a traditional soil conditioner.

The invention belongs to the field of pharmaceutical preparations. The invention relates to lipid nanoparticles modified by probiotic coupled galactose and coated with diammonium glycyrrhizinate, L-arginine and copper tannic acid nano enzyme as well as a preparation method and application of the lipid nanoparticles. The lipid nanoparticles prepared by coupling and wrapping the diammonium glycyrrhizinate, the L-arginine and the copper tannic acid nano-enzyme with the probiotics have good biocompatibility, the preparation method is simple, the particle size distribution of the nanoparticles is uniform, the half-life period of a medicine circulating in a body can be prolonged, the inherent beneficial functions of the probiotics are cooperated, and the bioavailability of the medicine is improved. The potential application value is realized in the fields of treating the metabolic dysfunction related steatohepatitis and the like.

The invention discloses a cobalt catalyst and a preparation method and application thereof. The structural formula of the cobalt catalyst is Co-Co3O4 (S)-coated NC-X, in the structural formula, S is the particle size of a cobalt active site, X is the pyrolysis temperature during preparation of the catalyst, and the microstructure of the cobalt catalyst is in a sphere-like shape sequentially comprising a cobalt core, cobaltosic oxide and a nitrogen-doped carbon shell from inside to outside. According to the invention, the catalyst is designed and prepared by using the cheap precursor, and the cobalt active sites are confined in the nitrogen-doped carbon shell, so that the agglomeration and loss of the cobalt active sites are effectively prevented, and the stability of the catalyst is improved. The cobalt catalyst can be used for synthesizing products of carbonyl compounds through selective catalytic oxidation with alcohol derivatives as substrates and air as an oxygen source, and has the advantages of being high in yield and efficient and green in reaction process.

The invention discloses a light conduction biological filler unit for water treatment, and relates to the technical field of sewage treatment.The light conduction biological filler unit comprises a light guiding component, a light shading component, light guiding components and biological attachments, the light shading component is installed at the bottom of the light guiding component, the light guiding components are arranged in the light shading component and inserted into water, and the biological attachments are arranged on the light guiding components. Biological attachments are attached to the surface of the light guide part, and the shading part is fixed to the water surface. According to the invention, light is input into water along with the light guide body, and the directions of nitrification and denitrification reactions are controlled by utilizing the promotion or inhibition effects of nitrifying bacteria and denitrifying bacteria under different illumination, so that the dependence on mechanical aeration is reduced, and pollutants in sewage are removed. Meanwhile, the thin optical fiber can also be used as a biological bed, photophilous microorganisms can grow on the surface of the optical fiber, and photosynthesis can also be realized in a deep water area in a biochemical pool, so that the removal rate of pollutants in sewage is further accelerated, the metabolic activity of algae can be improved, and an energy-saving effect is realized.

The application discloses a kind of adjustable defect sub-nanometer gold load nickel iron composite photoanode catalyst, preparation method and application, deionized water is introduced into nitrogen and is deoxidized, multi-walled carbon nanotube treated by strong acid is placed in deionized water after deoxidation, after ultrasonic dispersion is uniform, together with FeCl2, NiCl2, HMT and ammonium fluoride is added into reaction kettle, reaction is carried out at 120 DEG C for 6 hours, after cooling, it is taken out, using deionized water is filtered, washed after, HAuCl4 is quickly added, sealed and is stirred in dark room, after reaction is finished, it is filtered, washed, nitrogen is dried at room temperature and is preserved in oxygen-free atmosphere.The application is synthesized Au / NiFe (hydroxyl) oxide / CNT composite catalyst by in-situ oxidation technology one step.The method can be simultaneously controlled on the basis of heterojunction Defects, the synergistic effect of both makes the catalyst performance be further optimized.Synthesis method is simple and direct, and catalytic effect is obviously improved.

This invention provides a catalyst coated with a non-precious metal coating on a support and its preparation method. The invention also relates to the application of this non-precious metal coated-supported catalyst in the catalytic oxidation treatment of volatile organic compounds (VOCs). The catalyst of this invention has high mechanical strength, good coating wear resistance, and is not easily detached. Furthermore, the catalyst exhibits strong hydrothermal stability, good catalytic degradation performance of volatile organic compounds, and a long service life, making it particularly suitable for the treatment of VOCs containing sulfides.

This invention relates to novel compounds and their use as pharmaceuticals, more specifically for the prevention or treatment of diseases mediated by cGAS activity, particularly for the prevention or treatment of inflammatory conditions or cancer. The invention also relates to methods for preventing or treating said diseases, the methods comprising using the novel compounds. The invention further relates to pharmaceutical compositions or formulations of the novel compounds and their use as pharmaceuticals, more preferably for the prevention or treatment of diseases mediated by cGAS activity, particularly for the prevention or treatment of inflammatory conditions or cancer. The invention also relates to methods for preparing the compounds.

The present disclosure relates to compounds of Formula (I): and prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods of their preparation. The compounds disclosed herein are useful for modulating DNA polymerase theta activity and for the treatment of conditions involving DNA polymerase theta activity, such as cancer.

The invention discloses a wood frog egg oil soft capsule for inhibiting premature ovarian failure and a preparation method thereof, the wood frog egg oil soft capsule comprises wood frog egg oil, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, dunaliella salina aqueous extract, silybum marianum seed oil, chitosan oligosaccharide and white peony root aqueous extract. The preparation method of the wood frog egg oil soft capsule comprises the following steps: uniformly mixing wood frog egg oil freeze-dried powder, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, dunaliella salina aqueous extract, silybum marianum seed oil, chitosan oligosaccharide and white peony root aqueous extract in parts by mass through superfine grinding to obtain a wood frog oil compound; the oviductus ranae compound is prepared into a capsule content, and the capsule content is filled into a capsule shell by a soft capsule machine to prepare the soft capsule. The oviductus ranae soft capsule is rich in various nutritional ingredients, has an excellent function of inhibiting premature ovarian failure of women through scientific compatibility, and can effectively activate the activity of ovarian cells and promote normal metabolism and function maintenance of the ovarian cells.

The application belongs to the technical field of biology and particularly relates to application of ISL2 in regulating melatonin synthesis. The application discloses that ISL2 can be combined with a melatonin synthesis rate-limiting enzyme AANAT gene promoter, so as to regulate activity of the AANAT promoter, further regulate an expression amount of AANAT, and finally realize regulation of melatonin synthesis.