Wood frog egg oil soft capsule for inhibiting premature ovarian failure and preparation method of wood frog egg oil soft capsule

Abstract

The invention discloses a wood frog egg oil soft capsule for inhibiting premature ovarian failure and a preparation method thereof, the wood frog egg oil soft capsule comprises wood frog egg oil, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, dunaliella salina aqueous extract, silybum marianum seed oil, chitosan oligosaccharide and white peony root aqueous extract. The preparation method of the wood frog egg oil soft capsule comprises the following steps: uniformly mixing wood frog egg oil freeze-dried powder, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, dunaliella salina aqueous extract, silybum marianum seed oil, chitosan oligosaccharide and white peony root aqueous extract in parts by mass through superfine grinding to obtain a wood frog oil compound; the oviductus ranae compound is prepared into a capsule content, and the capsule content is filled into a capsule shell by a soft capsule machine to prepare the soft capsule. The oviductus ranae soft capsule is rich in various nutritional ingredients, has an excellent function of inhibiting premature ovarian failure of women through scientific compatibility, and can effectively activate the activity of ovarian cells and promote normal metabolism and function maintenance of the ovarian cells.

Description

Technical Field

[0001] The invention relates to the technical field of forest frog oil products, and in particular to a forest frog egg oil soft capsule for inhibiting premature ovarian failure and a preparation method thereof. Background Art

[0002] Rana sylvaticum egg oil is the oil extracted from the oviduct of mature female Rana sylvaticum through low temperature. It is rich in protein, fat, carbohydrates, vitamins and natural sex hormone estradiol. According to the theory of traditional Chinese medicine, Rana sylvaticum oil has the effects of nourishing the kidney and essence, moistening the lungs and nourishing yin, lowering blood lipids, etc. It has a certain effect on helping weak body and low immunity. It is a tonic product with extremely high nutritional value. The nutritional effect of Rana sylvaticum oil products in the prior art for inhibiting premature ovarian failure still needs to be improved.

[0003] Therefore, it is necessary to develop a kind of Rana sylvestris egg oil soft capsule that is rich in multiple nutrients and can inhibit premature ovarian failure. Summary of the invention

[0004] In order to solve the above technical problems, the purpose of the present invention is to provide a forest frog egg oil soft capsule for inhibiting premature ovarian failure and a preparation method thereof; the forest frog oil soft capsule is rich in various nutrients, and through scientific compatibility, has a relatively excellent function of inhibiting premature ovarian failure in women, can effectively activate the vitality of ovarian cells, and promote the normal metabolism and function maintenance of ovarian cells.

[0005] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0006] On one hand, the present invention provides a forest frog egg oil soft capsule for inhibiting premature ovarian failure, which comprises forest frog egg oil, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, salt algae water extract, milk thistle seed oil, chitosan oligosaccharide and white peony root water extract.

[0007] Preferably, the frog egg oil soft capsule for inhibiting premature ovarian failure comprises the following components in parts by mass: 100-150 parts of frog egg oil, 10-20 parts of squalene, 3-8 parts of vitamin E, 1-3 parts of American ginseng, 20-25 parts of maltodextrin, 10-18 parts of linseed oil, 2-5 parts of salt algae water extract, 2-5 parts of milk thistle seed oil, 10-15 parts of chitosan oligosaccharides, and 2-4 parts of white peony root water extract.

[0008] Further preferably, the frog egg oil soft capsule for inhibiting premature ovarian failure comprises the following components in parts by mass: 100-120 parts of frog egg oil, 10-15 parts of squalene, 3-5 parts of vitamin E, 1-2 parts of American ginseng, 20-25 parts of maltodextrin, 10-15 parts of linseed oil, 2-4 parts of salt algae water extract, 2-3 parts of milk thistle seed oil, 12-15 parts of chitosan oligosaccharides, and 2-3 parts of white peony root water extract.

[0009] More preferably, the frog egg oil soft capsule for inhibiting premature ovarian failure comprises the following components in parts by mass: 120 parts of frog egg oil, 10 parts of squalene, 3 parts of vitamin E, 1 part of American ginseng, 20 parts of maltodextrin, 15 parts of linseed oil, 4 parts of salt algae water extract, 2 parts of milk thistle seed oil, 12 parts of chitosan oligosaccharides, and 3 parts of white peony water extract.

[0010] Preferably, the forest frog egg oil soft capsule uses gelatin as the rubber.

[0011] The present invention also provides a method for preparing a soft capsule of Rana foetida egg oil for inhibiting premature ovarian failure, which specifically comprises the following steps: freeze-dried Rana foetida egg oil powder, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, water extract of Dunaliella salina, milk thistle seed oil, chitosan oligosaccharide and water extract of Paeonia lactiflora are uniformly mixed by ultrafine grinding according to a mass ratio to obtain a Rana foetida oil complex; after the Rana foetida oil complex is made into capsule contents, it is loaded into a rubber skin by a soft capsule machine to prepare a soft capsule.

[0012] Furthermore, in the above preparation method, the capsule contents include frog oil complex, corn oil, beeswax and a wetting agent, wherein the weight ratio of frog oil complex to corn oil is 1:(1.5-2.2), the amount of beeswax is 1%-2% of the weight of corn oil, and the amount of wetting agent is 0.1%-1% of the weight of corn oil.

[0013] Furthermore, in the above preparation method, the rubber is made of gelatin.

[0014] The beneficial effects of the present invention are:

[0015] (1) The nutrients in Rana sylvatica egg oil can provide nourishment for the ovaries, promote the normal metabolism and function maintenance of ovarian cells, and delay the aging of the ovaries. To a certain extent, it is beneficial for maintaining women's fertility and youthfulness. Many women suffer from menstrual disorders, acne, mood swings and other problems due to endocrine disorders. Rana sylvatica egg oil can act on the endocrine system, help regulate the secretion level of hormones in the body, keep estrogen, progesterone and other hormones relatively balanced, and thus improve irregular menstrual cycles and abnormal menstrual flow. At the same time, it also has a certain positive effect on alleviating emotional problems caused by endocrine disorders.

[0016] (2) Squalene has excellent antioxidant properties. It can remove these excess free radicals, reduce the oxidative damage caused by free radicals to ovarian cells, protect the integrity of ovarian cells, and allow ovarian cells to proliferate, differentiate, and perform corresponding physiological functions normally, thereby maintaining the stability of ovarian function. Squalene helps regulate the dilation and contraction of blood vessels, improves local microcirculation in the ovaries, and allows blood to flow more smoothly into the ovarian tissue. Although squalene is not a direct hormone substance, it indirectly regulates the process of ovarian hormone secretion by improving the functional state of ovarian cells, helping to maintain the relative stability of estrogen, progesterone and other hormone levels in the body, and avoiding a series of problems related to poor ovarian function, such as menstrual disorders and emotional abnormalities caused by hormone imbalance.

[0017] (3) Vitamin E is a fat-soluble antioxidant. It can capture and neutralize these free radicals through its own reducing properties, preventing the oxidation chain reaction caused by free radicals. It is like putting a layer of "protective clothing" on the ovarian cells, protecting the cell membranes and organelles from the damage of free radicals, maintaining the normal structure and functional integrity of the cells, and ensuring the normal physiological activities of the ovaries. Vitamin E can promote the synthesis of androgens by theca cells in the ovaries, and androgens are the precursors of estrogen synthesis. In this indirect way, it provides sufficient raw materials for the synthesis of estrogen, ensuring the stability of estrogen levels, and thus facilitating the normal development of follicles and ovulation. In the corpus luteum formed after ovulation, vitamin E helps maintain the function of corpus luteum cells and promotes the secretion of progesterone. Progesterone plays an important role in the subsequent conception process such as the transformation of the endometrium. This indirectly reflects that vitamin E ensures the orderly conduct of ovarian-related reproductive functions through its influence on progesterone.

[0018] (4) American ginseng can affect the secretion and regulation of hormones such as gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), so that the endocrine function of the ovaries is as normal as possible, avoiding premature ovarian function decline caused by hormone imbalance. Free radicals are constantly generated during ovarian physiological activities. When there are too many free radicals and the body's antioxidant defense system cannot remove them in time, they will cause oxidative damage to the follicular cells and granulosa cells in the ovaries, accelerating ovarian aging. Ginsenosides and other ingredients in American ginseng have antioxidant activity, which can remove excessive free radicals in the body, reduce oxidative stress damage to ovarian tissue, protect the structural and functional integrity of ovarian cells, and thus delay the process of premature ovarian failure. Women with premature ovarian failure often have reduced body resistance and are vulnerable to various diseases. American ginseng can improve the body's immune function, enhance the activity of immune cells such as T cells and B cells, promote the secretion of immune factors, and put the body in a better defensive state. In this way, the overall health level of women can be improved, and it also indirectly creates favorable physical conditions for the normal maintenance of ovarian function. Many women with premature ovarian failure will have symptoms of insufficient Qi and blood, such as sallow complexion, dizziness, fatigue, scanty menstruation, etc. American ginseng can improve women's Qi and blood conditions by replenishing Qi and Yin, increase the nourishment of Qi and blood, and enable the ovaries and other internal organs to obtain more adequate nutrition supply, which helps to restore and maintain the normal function of the ovaries.

[0019] (5) The most prominent component of flaxseed oil is α-linolenic acid, which can be converted into eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the human body through a series of complex metabolic pathways, such as through the action of desaturase and carbon chain elongation enzymes in the body, and further participate in physiological processes such as signal transduction in the body, indirectly affecting the functional regulation of the hypothalamus-pituitary-ovarian axis (HPO axis), helping to maintain the relative stability of the levels of sex hormones such as estrogen, thereby playing a certain protective role in ovarian function and delaying the occurrence of premature ovarian failure. The beneficial fatty acids in flaxseed oil help regulate the body's lipid metabolism, make the body's fat distribution more reasonable, and create a healthy microenvironment around endocrine organs such as the ovaries. Normal lipid metabolism is crucial for the synthesis of steroid hormones (including sex hormones such as estrogen), because part of the raw materials for the synthesis of steroid hormones comes from fat. When lipid metabolism is normal, it can ensure that the ovaries have sufficient raw materials to synthesize the required hormones and maintain their normal endocrine function. Ovarian cells continuously produce free radicals during metabolism. Excessive free radicals can trigger oxidative stress, damage follicular cells, granulosa cells and other structures in the ovaries, and accelerate ovarian aging. α-linolenic acid and other antioxidant components in flaxseed oil have certain antioxidant capacity, which can capture and remove free radicals, reduce the damage of oxidative stress to ovarian tissue, protect the integrity of ovarian cells, and thus delay the process of ovarian function decline.

[0020] (6) The natural β-carotene in the salt algae extract is a powerful antioxidant with a special structure of multiple conjugated polyene double bonds. It can undergo irreversible reactions with oxygen-containing free radicals, effectively scavenging free radicals and quenching singlet oxygen. It can also capture and scavenging peroxide free radicals, creating a relatively healthy internal environment for ovarian cells, protecting them from excessive damage by free radicals, maintaining the normal structure and functional integrity of ovarian cells, and thus delaying the occurrence of premature ovarian failure. The effective ingredients of salt algae polysaccharides in the salt algae extract can repair sugar chains, restore the normal expression and recognition of intercellular information, ensure accurate signal transmission between ovarian cells, and enable various physiological activities in ovarian tissue to proceed in an orderly manner, which is of great significance for maintaining the normal function of the ovaries and preventing premature ovarian failure.

[0021] (7) Milk thistle seed oil is rich in antioxidant ingredients, such as flavonoids. Oxidative stress is an important pathological mechanism in the process of premature ovarian failure. Excessive free radicals in the body can damage cells in the ovarian tissue, including follicular cells and ovarian interstitial cells. The antioxidants in milk thistle seed oil can remove these free radicals and reduce the damage of oxidative stress to ovarian cells, thereby protecting ovarian function to a certain extent. Milk thistle seed oil plays a signal regulating role in the hormone regulation system, promoting the normal secretion of hormones by the ovaries, thereby improving the symptoms of hormone imbalance caused by premature ovarian failure, such as menstrual disorders and hot flashes.

[0022] (8) The antioxidant capacity of chitosan oligosaccharides helps maintain the redox balance in ovarian cells, thereby protecting ovarian function. Premature ovarian failure is closely related to autoimmune factors. In some patients, ovarian function declines due to the autoimmune system mistakenly attacking ovarian tissue. Chitosan oligosaccharides can regulate the activity of immune cells, such as regulating the functions of T lymphocytes, B lymphocytes and macrophages. Chitosan oligosaccharides help improve local microcirculation in the ovaries. Good blood circulation is very important for the nutrient supply of ovarian tissue and the discharge of metabolic waste.

[0023] (9) White peony root water extract can regulate the hypothalamus-pituitary-ovarian axis (HPO axis). Premature ovarian failure is closely related to the dysfunction of the HPO axis, which is like a command center that regulates the female reproductive cycle and hormone secretion. White peony root water extract can improve ovarian function by regulating this axis. The antioxidants in white peony root water extract can scavenge these free radicals and reduce ovarian oxidative damage. White peony root water extract can reduce the inflammatory response of ovarian tissue.

[0024] The forest frog oil soft capsule of the present invention is rich in various nutrients, and through scientific compatibility, has a relatively excellent function of inhibiting premature ovarian failure in women, can effectively activate the vitality of ovarian cells, and promote the normal metabolism and function maintenance of ovarian cells. DETAILED DESCRIPTION

[0025] The technical solutions in the present invention will be described clearly and completely below in conjunction with specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] The invention provides a frog egg oil soft capsule for inhibiting premature ovarian failure. The soft capsule comprises frog egg oil, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, salt algae water extract, milk thistle seed oil, chitosan oligosaccharide and white peony root water extract.

[0027] The frog egg oil soft capsule for inhibiting premature ovarian failure comprises the following components by weight: 100-150 parts of frog egg oil, 10-20 parts of squalene, 3-8 parts of vitamin E, 1-3 parts of American ginseng, 20-25 parts of maltodextrin, 10-18 parts of linseed oil, 2-5 parts of salt algae water extract, 2-5 parts of milk thistle seed oil, 10-15 parts of chitosan oligosaccharide, and 2-4 parts of white peony root water extract. Preferably, the soft capsule comprises the following components: 100-120 parts of frog egg oil, 10-15 parts of squalene, 3-5 parts of vitamin E, 1-2 parts of American ginseng, 20-25 parts of maltodextrin, 10-15 parts of linseed oil, 2-4 parts of salt algae water extract, 2-3 parts of milk thistle seed oil, 12-15 parts of chitosan oligosaccharide, and 2-3 parts of white peony root water extract.

[0028] Most preferably, the frog egg oil soft capsule for inhibiting premature ovarian failure comprises the following components: 120 parts of frog egg oil, 10 parts of squalene, 3 parts of vitamin E, 1 part of American ginseng, 20 parts of maltodextrin, 15 parts of linseed oil, 4 parts of salt algae water extract, 2 parts of milk thistle seed oil, 12 parts of chitosan oligosaccharide, and 3 parts of white peony root water extract.

[0029] The method for preparing the frog egg oil soft capsule for inhibiting premature ovarian failure comprises the following steps: freeze-dried frog egg oil powder, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, water extract of salt algae, milk thistle seed oil, chitosan oligosaccharide and water extract of white peony root are uniformly mixed by ultrafine grinding according to the mass ratio, and then sieved to obtain the frog oil complex; after the frog oil complex is made into capsule contents, it is loaded into a rubber skin by a soft capsule machine to make a soft capsule. In the preparation method, the rubber skin is preferably gelatin.

[0030] In the above preparation method, the capsule contents include frog oil complex, corn oil, beeswax and a wetting agent, wherein the weight ratio of frog oil complex to corn oil is 1:(1.5-2.2), the amount of beeswax is 1%-2% of the weight of corn oil, and the amount of wetting agent is 0.1%-1% of the weight of corn oil.

[0031] Example 1

[0032] The frog egg oil soft capsule for inhibiting premature ovarian failure comprises the following components in parts by mass: 100 parts of frog egg oil, 12 parts of squalene, 5 parts of vitamin E, 1 part of American ginseng, 25 parts of maltodextrin, 12 parts of linseed oil, 2 parts of salt algae water extract, 3 parts of milk thistle seed oil, 10 parts of chitosan oligosaccharide, and 2 parts of white peony root water extract.

[0033] The method for preparing the frog egg oil soft capsule for inhibiting premature ovarian failure is specifically as follows: freeze-dried frog egg oil powder, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, water extract of salt algae, milk thistle seed oil, chitosan oligosaccharide and water extract of white peony root are uniformly mixed by ultrafine grinding according to the mass ratio, and then sieved to obtain the frog oil complex; after the frog oil complex is made into capsule contents, it is loaded into a rubber skin by a soft capsule machine to make a soft capsule. In the preparation method, the rubber skin is gelatin.

[0034] In the above preparation method, the capsule contents include 150 parts of Rana sylvatica oil complex, 230 parts of corn oil, 2.5 parts of beeswax and 1.2 parts of wetting agent Tween 80.

[0035] Example 2

[0036] The frog egg oil soft capsule for inhibiting premature ovarian failure comprises the following components in parts by mass: 120 parts of frog egg oil, 10 parts of squalene, 3 parts of vitamin E, 1 part of American ginseng, 20 parts of maltodextrin, 15 parts of linseed oil, 4 parts of salt algae water extract, 2 parts of milk thistle seed oil, 12 parts of chitosan oligosaccharide, and 3 parts of white peony root water extract.

[0037] The method for preparing the frog egg oil soft capsule for inhibiting premature ovarian failure is specifically as follows: freeze-dried frog egg oil powder, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, water extract of salt algae, milk thistle seed oil, chitosan oligosaccharide and water extract of white peony root are uniformly mixed by ultrafine grinding according to the mass ratio, and then sieved to obtain the frog oil complex; after the frog oil complex is made into capsule contents, it is loaded into a rubber skin by a soft capsule machine to make a soft capsule. In the preparation method, the rubber skin is gelatin.

[0038] In the above preparation method, the capsule contents include 150 parts of Rana sylvatica oil complex, 300 parts of corn oil, 2.5 parts of beeswax and 1.2 parts of wetting agent Tween 80.

[0039] Example 3

[0040] The frog egg oil soft capsule for inhibiting premature ovarian failure comprises the following components in parts by mass: 150 parts of frog egg oil, 15 parts of squalene, 3 parts of vitamin E, 2 parts of American ginseng, 25 parts of maltodextrin, 15 parts of linseed oil, 5 parts of salt algae water extract, 3 parts of milk thistle seed oil, 12 parts of chitosan oligosaccharide, and 3 parts of white peony root water extract.

[0041] The method for preparing the frog egg oil soft capsule for inhibiting premature ovarian failure is specifically as follows: freeze-dried frog egg oil powder, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, water extract of salt algae, milk thistle seed oil, chitosan oligosaccharide and water extract of white peony root are uniformly mixed by ultrafine grinding according to the mass ratio, and then sieved to obtain the frog oil complex; after the frog oil complex is made into capsule contents, it is loaded into a rubber skin by a soft capsule machine to make a soft capsule. In the preparation method, the rubber skin is gelatin.

[0042] In the above preparation method, the capsule contents include 150 parts of Rana sylvatica oil complex, 300 parts of corn oil, 2.5 parts of beeswax and 1.2 parts of wetting agent Tween 80.

[0043] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-restrictive in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention.

[0044] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A forest frog egg oil soft capsule for inhibiting premature ovarian failure, characterized in that: Including frog egg oil, squalene, vitamin E, American ginseng, maltodextrin, flaxseed oil, salt algae water extract, milk thistle seed oil, chitosan oligosaccharide and white peony water extract.

2. A forest frog egg oil soft capsule for inhibiting premature ovarian failure according to claim 1, characterized in that: The invention comprises the following components in parts by mass: 100-150 parts of forest frog egg oil, 10-20 parts of squalene, 3-8 parts of vitamin E, 1-3 parts of American ginseng, 20-25 parts of maltodextrin, 10-18 parts of linseed oil, 2-5 parts of salt algae water extract, 2-5 parts of milk thistle seed oil, 10-15 parts of chitosan oligosaccharide and 2-4 parts of white peony root water extract.

3. A forest frog egg oil soft capsule for inhibiting premature ovarian failure according to claim 2, characterized in that: The invention comprises the following components in parts by mass: 100-120 parts of forest frog egg oil, 10-15 parts of squalene, 3-5 parts of vitamin E, 1-2 parts of American ginseng, 20-25 parts of maltodextrin, 10-15 parts of linseed oil, 2-4 parts of salt algae water extract, 2-3 parts of milk thistle seed oil, 12-15 parts of chitosan oligosaccharide and 2-3 parts of white peony root water extract.

4. A forest frog egg oil soft capsule for inhibiting premature ovarian failure according to claim 3, characterized in that: The invention comprises the following components in parts by mass: 120 parts of forest frog egg oil, 10 parts of squalene, 3 parts of vitamin E, 1 part of American ginseng, 20 parts of maltodextrin, 15 parts of linseed oil, 4 parts of salt algae water extract, 2 parts of milk thistle seed oil, 12 parts of chitosan oligosaccharide and 3 parts of white peony root water extract.

5. A forest frog egg oil soft capsule for inhibiting premature ovarian failure according to claim 1, characterized in that: The forest frog egg oil soft capsule adopts gelatin as the rubber cover.

6. A method for preparing the forest frog egg oil soft capsule for inhibiting premature ovarian failure as claimed in any one of claims 1 to 5, characterized in that: Freeze-dried powder of Rana foetida egg oil, squalene, vitamin E, American ginseng, maltodextrin, linseed oil, water extract of Dunaliella salina, milk thistle seed oil, chitosan oligosaccharide and water extract of Paeonia lactiflora are uniformly mixed and ultrafinely ground according to mass proportions to obtain a Rana foetida oil complex; after the Rana foetida oil complex is made into capsule contents, it is loaded into a rubber capsule using a soft capsule machine to prepare a soft capsule.

7. The method for preparing the forest frog egg oil soft capsule for inhibiting premature ovarian failure according to claim 6, characterized in that: The capsule content includes forest frog oil complex, corn oil, beeswax and wetting agent, wherein the weight ratio of forest frog oil complex to corn oil is 1:(1.5-2.2), the amount of beeswax is 1%-2% of the weight of corn oil, and the amount of wetting agent is 0.1%-1% of the weight of corn oil.

8. The method for preparing the forest frog egg oil soft capsule for inhibiting premature ovarian failure according to claim 6, characterized in that: The rubber is made of gelatin.