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Food nutrition absorption and utilization evaluation method taking sialic acid as marker and application

A technology of nutrient absorption and evaluation method, which is applied in the field of evaluation of food nutrient absorption and utilization, and can solve the problems of lack of effective means for evaluation

Active Publication Date: 2021-01-29
厦门市燕之屋丝浓食品有限公司
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Problems solved by technology

[0006] In view of the diversity of sialic acid functions and the uniqueness of food sources, there is a lack of effective means to evaluate the efficacy of food sialic acid

Method used

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  • Food nutrition absorption and utilization evaluation method taking sialic acid as marker and application
  • Food nutrition absorption and utilization evaluation method taking sialic acid as marker and application
  • Food nutrition absorption and utilization evaluation method taking sialic acid as marker and application

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Embodiment Construction

[0029] The following embodiments will further illustrate the present invention in conjunction with the accompanying drawings.

[0030] The embodiment of the method for evaluating the absorption and utilization of food nutrients marked by sialic acid according to the present invention comprises the following steps:

[0031] Configure the test object:

[0032] Sialic acid intervention dose setting: The recommended amount of bird’s nest in classical books is 3 to 5g per day. Based on 5g, the content of sialic acid in bird’s nest is about 7% to 12%, and based on 10%, the recommended daily amount for a 50kg adult is 0.01 g / kg, as the initial dose. According to the conversion of human and mouse body surface area, the initial dose of sialic acid in mice is 0.090g / kg, and four dose groups are set at this dose: low, medium, high and extremely high dose groups, respectively 0.045g / kg, 0.090 g / kg, 0.180g / kg, 0.360g / kg; prepare sialic acid solutions with concentrations of 4.5g / L, 9.0g / L...

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Abstract

The invention discloses a food nutrition absorption and utilization evaluation method taking sialic acid as a marker and application, and relates to detection and evaluation of food nutritional ingredients. The food nutrition absorption and utilization evaluation method comprises the following steps of: 1) dividing male ICR mice into four dose groups, namely a low dose group, a medium dose group,a high dose group and an extremely high dose group, and respectively and continuously carrying out intragastric administration on the mice; 2) collecting blood at different time points, separating theblood into plasma, precipitating plasma protein, and extracting an erythrocyte membrane; 3) detecting the content of free sialic acid, erythrocyte membrane sialic acid and protein-bound sialic acid in mouse blood; and 4) drawing a dose time concentration curve, and constructing an ordinary differential equation model of sialic acid in-vivo metabolism. An ordinary differential equation can be usedfor describing a simple and linear in-vivo metabolic process in pharmacokinetics, and a dynamic process and a change rule among studies are disclosed by establishing a relationship among variables. The food nutrition absorption and utilization evaluation method simplifies biological complexity, and can be used for evaluating and predicting the absorption and utilization of the sialic acid-containing food.

Description

technical field [0001] The invention relates to the detection and evaluation of food nutritional components, in particular to an evaluation method and application of food nutrition absorption and utilization marked by sialic acid. Background technique [0002] Sialic acid (Sialic Acids, SA) is a general term for a diverse family of monosaccharides with nine carbon atoms as the backbone. Human body fluids such as saliva, gastric juice, tears, serum, urine and breast milk contain sialic acid. N-acetylneuraminic acid (N-acetylneuraminicacids, Neu5Ac) is the main sialic acid in the human body, easily soluble in water, with a molecular weight of 309.270g / mol[1] (1. Schauer R. Sialic acids: fascinating sugars in higher animals and man[J].Zoology(Jena), 2004,107(1):49-64.), the term sialic acid usually refers to Neu5Ac. [0003] Sialic acid is located at the end of the sugar chain of complex carbohydrates on the cell surface, modifying all cell surfaces and most of the secreted p...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N1/34G16C20/50G06F17/13
CPCG01N1/34G01N21/6486G06F17/13G16C20/50
Inventor 李红卫庄滢滢张薇黄兴成陈小旋郭东北金鑫
Owner 厦门市燕之屋丝浓食品有限公司
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