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Drug for inhibiting myocardial hypertrophy and construction method of model

A technology for cardiac hypertrophy and construction methods, applied in biochemical equipment and methods, drug combinations, cell dissociation methods, etc.

Pending Publication Date: 2022-02-18
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the prior art, there is no case of using bio-sourced nano-selenium to relieve or treat Ang II-induced cardiac hypertrophy in broilers

Method used

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  • Drug for inhibiting myocardial hypertrophy and construction method of model
  • Drug for inhibiting myocardial hypertrophy and construction method of model
  • Drug for inhibiting myocardial hypertrophy and construction method of model

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Embodiment 1

[0044] 1. In vivo experiment

[0045] The present invention is based on the research on the prevention and treatment of broiler pulmonary hypertension syndrome. According to the currently recognized pathogenesis of broiler pulmonary hypertension syndrome, broiler cardiac muscle hypertrophy is the premise of broiler pulmonary hypertension syndrome, so broiler cardiac muscle hypertrophy is successfully produced. A hypertrophic model was a prerequisite for the study to proceed. In the study of myocardial hypertrophy in mammals, cardiac hypertrophy models were created by arterial ligation, isoproterenol, tumor necrosis factor alpha (TNF-α), insulin (Ins), angiotensin II (Ang II) and other methods. Due to the large number of broiler chicken samples and the low sensitivity to anesthesia and the difficult operation, surgical arterial ligation is not applicable. Compared with other drugs, Ang II is the most classic drug for simulating myocardial hypertrophy, and its Mainly through th...

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Abstract

The invention belongs to the technical field of animal model construction, and discloses a drug for inhibiting myocardial hypertrophy and a construction method of a model. 60 1-day-old white feather broilers are selected and adaptively fed to an age of 10 days, and the white feather broilers are randomly divided into a blank control group, an Ang II high-dose group, an Ang II low-dose group, a nano-selenium + Ang II high-dose group and a nano-selenium + Ang II low-dose group. 15-day-old white feather broiler embryos are selected, and broiler primary myocardial cells are extracted and treated with Ang II of 2.5 * 10 <-4 > mM for 48 hours to obtain a broiler myocardial hypertrophy in-vitro model. Then, the cells are co-treated for 48 hours by adopting nano-selenium with different concentrations and Ang II with the concentration of 2.5 * 10 <-4 > mM, and the action mechanism of the nano-selenium for relieving the myocardial hypertrophy of the broilers is explored. The method can be used for researching whether biogenic nano-selenium can inhibit myocardial hypertrophy by inhibiting generation of free radicals of organisms or not.

Description

technical field [0001] The invention belongs to the technical field of animal model construction, and in particular relates to a drug for inhibiting cardiac hypertrophy and a method for constructing a model. Background technique [0002] Currently: broiler pulmonary hypertension syndrome (Pulmonary hypertension syndrome, PHS)) is also called broiler ascites syndrome (Ascites syndrome in broiler, AS), is a common non-infectious metabolic disease in broiler chickens that occurs in high-altitude cold regions. Internal medicine disease is one of the main diseases affecting the development of broiler chicken breeding industry in the country of the present invention. At present, the cause of PHS is still unclear, but the recognized pathogenesis at this stage is: broiler chickens grow too fast or are cold, which leads to an increase in the body's oxygen supply, and the anatomical structure of the poultry's lungs leads to the body's oxygen supply. Insufficient oxygen, leading to re...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61P9/00A61P9/04C12N5/077A01K67/02
CPCA61K33/04A61P9/00A61P9/04C12N5/0657A01K67/02C12N2509/00
Inventor 周东海杨小琦符杨张嘉宾刘佳琪史箐箐刘鑫汪璐
Owner HUAZHONG AGRI UNIV
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