Traditional Chinese medicine cancer toxin prescription for treating liver cancer and application thereof in pharmacy

Abstract

The invention discloses a traditional Chinese medicine cancer toxin prescription for treating liver cancer and application thereof in the preparation of medicaments for resisting liver cancer. The cancer toxin prescription is prepared in accordance with the cancer toxin theory proposed by traditional Chinese medicine master Professor Zhou Zhongying, and is prepared from hedyotidis herba, muscardine silkworm, centipede, akebia fruit, pseudostellaria root, dwarf lilyturf root and rhizoma pleionis according to a certain weight ratio. The prescription has the main functions of eliminating pathogens, eliminating cancer and detoxicating and the auxiliary function of strengthening healthy qi. By using mice with liver cancer H22 transplantation tumor as materials, the pharmacological experiment result shows the cancer resistance effect of the cancer toxin prescription: the tumor inhibition rates of a low-dose group, an intermediate-dose group and a high-dose group are respectively 24.5%, 42.8% and 21.1%, thereby showing the effect of inhibiting the growth of H22 tumor mass; the tumor mass cell apoptosis rates of the low-dose group, the intermediate-dose group and the high-dose group are respectively 47.16%, 60.52% and 57.59%, thereby showing the effect of inducing tumor cells to die; and the cancer toxin prescription can block the high expression of TLR4, block the MyD88 dependent pathway of TLR4 intracellular signal transduction and inhibit the expression of downstream NF-kB proteins. Experiment shows that the cancer toxin prescription can be used for preparing medicaments for resisting liver cancer.

Description

technical field [0001] The invention relates to cell biology and molecular biology techniques in the field of traditional Chinese medicine, in particular to a Chinese medicine cancer poison prescription for treating liver cancer and its application in preparing anti-liver cancer drugs. Background technique [0002] Liver cancer is one of the major diseases that seriously endanger human life and health. It is one of the most common malignant tumors in my country. The mortality rate has increased by 41.17% in recent years, and its morbidity and mortality are still increasing year by year. Liver cancer has the characteristics of late discovery, rapid development, difficult treatment, and poor prognosis. It is called "the king of cancers". After resection, the recurrence rate is still as high as 60% 5 years after operation, and the recurrence rate of small liver cancer is also as high as 40%-50%. [0003] Western medicine treats liver cancer to directly fight against a certain ...

AI Technical Summary

Problems solved by technology

Some studies have found that traditional Chinese medicine can play an anti-tumor effect by affecting the TLRs / NF-κB pathway in immune cells, but there are no reports on the direct effect of traditional Chinese medicine on this pathway of tumor cells at home and abroad.

Images