Disclosed are a novel ITO crossover integrated capacitive touch screen and a manufacturing method thereof. The novel ITO crossover integrated capacitive touch screen comprises a transparent substrate, and a silicon dioxide layer, a niobium pentoxide layer, a black resin layer, an ITO crossover electrode, a first insulation layer, an ITO electrode, a metal electrode, and a second insulation layer sequentially stacked on the transparent substrate. The silicon dioxide layer covers the glass completely, and the niobium pentoxide layer covers the silicon dioxide layer completely. The ITO electrode comprises a capacitive screen driver and a sensing electrode, and is provided with a patterned graphic structure. The capacitive screen driver and the sensing electrode are on the same layer, mutually independent, mutually insulated, and vertical in design. By the reasonable design for the stacked structure and the crossover conductive mode of the capacitive touch screen, the present invention can effectively improve the transmittance of the capacitive touch screen and reduce the visibility of the ITO pattern, and the reliability of the touch screen is further improved. novel ITO crossover integrated capacitive touch screen.