Injectable natural hydrogel system with temperature sensitive feature and high tissue adhesive force and preparation method thereof

A natural water, temperature-sensitive technology, applied in the field of medical biomaterials, can solve the problems of low catechol grafting rate, unfavorable scale-up production, slow reaction speed, etc., and achieve good biocompatibility and degradability, high tissue quality Adhesion, not easy to shift effect
CN108159482AInactive Publication Date: 2018-06-15SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD
Publication Date
2018-06-15
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention relates to an injectable natural hydrogel system with a temperature sensitive feature and high tissue adhesive force. The system is prepared through Schiff base reactions between micromolecular compounds containing catechol groups and a -NH2 containing temperature sensitive natural polymer material. The system has the advantages of quick temperature responding speed, good biocompatibility, good degradation property, high gel mechanical strength, and high tissue adhesive force, can be firmly adhered on needed parts in a wet environment, and is difficult to shift. At the same time,the preparation technology (Schiff base reactions) is simple, the reaction efficiency is high, and the reaction conditions are mild. During the preparation process, no any chemical crosslinking agent, activator, or photo-sensitizer is introduced into the production system, the production purification technology is simple, the maneuverability in the production process is improved for enterprises,and the preparation method is suitable for industrialization and amplified production.
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Description

technical field

[0001] The invention relates to the technical field of medical biomaterials, in particular to an injectable natural hydrogel and a preparation method thereof, which can be applied to surgical operations such as tissue adhesion and anti-adhesion, as well as tissue repair and drug release systems. Background technique

[0002] Hydrogel has a three-dimensional network structure similar to extracellular matrix, which is beneficial to the growth of cells and the exchange of metabolic substances, so it has a wide range of applications in biomedical fields such as tissue repair and drug release. In recent years, injectable hydrogels have attracted the attention of researchers because of their unique advantages. Injectable hydrogel is to inject a biological material with certain fluidity into the desired site, and then quickly realize the sol-gel transition in the in vivo environment, adhere to the site and play a specific role. Therefore, injectable hydrogels are e...

Claims

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