84results about How to "Suitable for scale-up" patented technology

Disclosed are a lithium secondary battery comprising a fibrous membrane / electrode composite in which an ultra-fine fibrous porous polymer membrane is combined with an electrode into one body and a hybrid type polymer electrolyte in which pores of the ultra-fine fibrous porous polymer membrane is impregnated with an organic electrolyte solution or a polymer electrolyte; and a fabrication method thereof.

A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding chimeric influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

The invention belongs to the technical field of advanced nanocomposites, and particularly relates to a magnetic mesoporous silica nanochain with a core-shell structure and a preparation method of thenanochain. The method comprises the following steps of firstly, coating a layer of amorphous silica on the surface of magnetic inorganic nanoparticles by using a sol-gel chemical synthesis method, andinducing oriented arrangement of the magnetic inorganic nanoparticles to form a one-dimensional core-shell structure nanochain through applying an external magnetic field; secondly, utilizing an organic surfactant as a self-assembly behavior of a structure-directing agent and an inorganic species in solution, and coating a layer of silica / surfactant composite on the surface of a magnetic inorganic nanoparticle / silica composite nanochain through an organic chambering solvent; and finally, removing the surfactant through solvent extraction in order to obtain a magnetic inorganic nanoparticle / silica core-shell structure nanochain composite with ordered mesoporous vertical divergence pore channels. The nanochain has a relatively high specific surface area, a large pore size, good magnetic responsiveness and biocompatibility, and a wide application prospect in the aspects of biological separation, adsorption, drug loading and the like.

The invention belongs to the technical field of advanced nanocomposite materials, and in particular to a highly dispersed noble metal-loaded ordered mesoporous tungsten oxide gas-sensitive material and a preparation method thereof. By a sol-gel chemical synthesis method, the invention utilizes an amphiphilic block copolymer as a structure-directing agent, hydrophilic blocks are assembled with a metallic oxide precursor in solution by hydrogen bonds and coordination, hydrophobic blocks wrap an oil-soluble noble metal precursor by a hydrophobic effect, and after solvent evaporation-induced co-assembly and high-temperature heat treatment, the noble metal-loaded ordered mesoporous tungsten oxide material is directly obtained. The composite material has a highly ordered mesoporous structure, large specific surface area and highly dispersed, stable noble metal particles with uniform size, and can be used in the preparation of gas sensors, the composite material has excellent sensitivity andselectivity on carbon monoxide, and response and recovery times are extremely short. The method disclosed by the invention is simple, the complexity of multi-step synthesis is overcome, the method issimple, controllable and suitable for enlarged production, and the invention has a broad application prospect in the field of gas sensing.

A composite hollow fibre membrane based on the composite resistance Henis membrane model (silica rubber / polysulfone membrane) for separating H2 or N2 with high effect is composed of basic membrane, water-soluble high-molecular layer in rubber state at ordinary temp and silica rubber layer. It can be used for the ammonia synthesizing plant or oil refinary to recover N2 or H2. Its preparing process is also disclosed.

The invention discloses a tissue engineering bracket applicable to human body organ construction, and the tissue engineering bracket has the bore diameter of 5 mu m-200 mu m, good bore connectivity and proper degradability, and can be applicable to growth of cells in the bracket. The invention further discloses a preparation method of the tissue engineering bracket applicable to human body organ construction. The preparation method comprises the following steps: firstly preparing sericin liquor, chitosan liquor and sodium glycerophosphate liquor into mixed liquor; then, converting the mixed liquor into a gel state; finally, obtaining the tissue engineering bracket by virtue of a process comprising freezing and drying, placing and softening, and high-pressure steam treating. By regulating the ratio of the sericin liquor, chitosan liquor and sodium glycerophosphate liquor or changing process conditions, the bore diameter size and degradation performance of the obtained tissue engineering bracket can be obtained in a controlled manner, so that the tissue engineering bracket satisfies the requirements of the tissue engineering bracket applicable to human body organ construction. The preparation method has the advantages of being gentle in reaction condition, simple in process and low in material cost, and is suitable for industrial scale-up production.

A purified antibody, or an antigen-binding fragment thereof, is provided that binds selectively to a protein specific to an X-chromosome of a mammalian sperm cell. The sperm cell protein comprises an amino acid sequence set forth in SEQ ID NOs: 4 and 9-16. The antibody or antigen-binding fragment thereof may be derived by immunization of a host by an antigenic peptide composition comprising one or more natural or synthetic antigenic peptide sequences set forth as SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NOs: 4 and 9-16. The antibody finds utility in identifying an X-chromosome bearing sperm cell population, and in methods for skewing a sex ratio in mammals.

The invention discloses an aluminum modified Fe3O4 magnetic material and a preparing method and application thereof and belongs to the fields of preparation and organic catalysis of magnetic catalysts. The aluminum modified Fe3O4 magnetic material is obtained through in situ synthesis by means of the solvothermal method, and is used as a catalyst to catalyze H2O2 in a water phase and oxidize benzyl alcohol selectively so as to prepare benzaldehyde. The raw materials of the prepared catalyst are cheap and easy to obtain, and operation is easy and convenient. A catalytic reaction system for synthesizing benzaldehyde is environmentally friendly, the yield of benzaldehyde is high (43.7%), and magnetic separation recovery and regeneration cyclic use of the catalyst are easy to achieve; furthermore, no byproduct containing chlorine exists in benzaldehyde, so that application in the fields such as spice and medicine is possible, and application prospects are broad.

The invention discloses a high-performance polylactic acid nano composite material and a preparation method thereof, and the high-performance polylactic acid nano composite material is composed of thefollowing components in parts by weight: 93-99 parts of polylactic acid and 1-7 parts of zinc complex modified cellulose nanocrystalline. According to the invention, the cellulose nanocrystal modified by the zinc complex is used as a modifier, so that the performance of polylactic acid can be effectively improved. The polylactic acid nano composite material prepared by the invention has excellentultraviolet shielding property, antibacterial property, mechanical property, water vapor barrier property and fluorescence property, low hygroscopicity, low cytotoxicity and low hydrophilicity, and is simple in preparation process, easy in chemical component control, good in repeatability, and higher in yield; the polylactic acid composite material has potential application value in the fields ofpackaging materials, biomedical materials and the like, is suitable for large-scale production, and expands the application field of the polylactic acid composite material.

The invention discloses a preparation method of an Nb3O7F nanoarray / graphene heterojunction composite material. The preparation method comprises the following steps: preparing a graphene water solution, stirring, and carrying out ultrasonic stripping until graphene forms uniform dispersion liquid; adding hydrofluoric acid into the dispersion liquid, simultaneously carrying out stirring and ultrasonic treatment so as to adequately etch the surface of stripped graphene to form a carbon-fluorine bond; weighing NbCl5 powder, adding the NbCl5 powder into the solution, adequately stirring, adding hydrofluoric acid, and continuing to adequately stir; transferring the solution into a reaction kettle with a Teflon liner, and carrying out hydrothermal reaction; after the reaction is finished, carrying out centrifugal separation on a product, washing by virtue of deionized water and absolute ethyl alcohol, and drying in a drying oven; and carrying out thermal treatment on the dried product to remove organic matters, so as to finally obtain the Nb3O7F nanoarray / graphene heterojunction composite material. The preparation method has the beneficial effects that the process is simple, the operation conditions are easily controlled, and the low-temperature preparation of the graphene heterojunction material is realized.

The invention provides a method for synthesizing tiagabine hydrochloride, which has the following synthesizing route. The invention also provides a method for preparing anhydrous tiagabine hydrochloride of medicinal preparation level in a single or mixed organic solvent. An important dithiophene N-alkylated intermediate is prepared by the compact synthesizing method; and the synthesizing route does not need expensive special reagents, is convenient to operate, has mild reaction conditions, and is suitable for expanded preparation. In addition, when the anhydrous tiagabine hydrochloride is prepared by adopting the single or mixed organic solvent, the residual organic solvent is tried to remove so that the anhydrous tiagabine hydrochloride meets the requirement of a medicament preparation.

A process for synthesizing Gabitril used to prepare the medicines for treating epilepsy and the diseases associated with GABA, its recemate, and its S-configuration are disclosed. Its advantage is low cost.

The invention belongs to the technical field of polymer composite materials, and relates to a polyvinyl alcohol composite material with ultraviolet blocking and antibacterial functions and a preparation method thereof, wherein the polyvinyl alcohol composite material is prepared from the following raw materials: polyvinyl alcohol, and cobalt complex crystal [Co4(H8P3NC3O9)2].H2O, wherein in the formula, (H8P3NC3O9) is an anion of amino trimethylene phosphonic acid losing four protons. The invention also provides the preparation method of the polyvinyl alcohol composite material. The polyvinyl alcohol composite material prepared by the preparation method has excellent ultraviolet blocking property, antibacterial property, ammonia response property, mechanical property, water vapor permeability and thermal stability, can maintain high optical transparency, is simple in preparation process, is suitable for large-scale production, and has potential application value in the fields of packaging, antibacterial materials, ammonia gas detection and the like.

The invention provides a large area nitrogen-doped carbon nano-tube paper preparation method, which comprises: (1) weighing ferrocene powder, dissolving in dichlorobenzene to form a ferrocene / dichlorobenzene carbon source solution, weighing pyridine, and mixing the pyridine and the ferrocene / dichlorobenzene carbon source solution to form a ferrocene / dichlorobenzene / pyridine mixing carbon source solution; 2) coiling an iron sheet or copper sheet substrate into a cylindrical material, placing into the quartz reaction chamber of a reaction furnace, sealing the reaction chamber, introducing argon gas to completely discharge air, and heating the reaction furnace; 3) when the temperature of the reaction chamber achieves 750-900 DEG C, adjusting the argon flow rate while introducing hydrogen; 4) injecting the ferrocene / dichlorobenzene / pyridine mixing carbon source solution into the reaction chamber, and carrying out a reaction; and 5) stopping the heating of the tubular reaction furnace, closing the hydrogen, adjusting argon flow rate to make the product be cooled to a room temperature along with the furnace, and collecting the large area nitrogen-doped carbon nano-tube paper on the substrate. According to the present invention, the nitrogen-doped structure carbon nano-tube film two-dimensional structure and the simple, rapid and large-scale preparation method can be used for the fields of new energy sources, sensors, flexible electronic devices, and the like.

The present invention relates to a novel process for the synthesis of everolimus of formula (I): and intermediates thereof.

A preparation method of a mesoporous LTA zeolite adopts a bridged silsesquioxane monomer as a mesoporous template, and comprises firstly mixing bridged silsesquioxane with silicon species solution, stirring to be clear, then slowly dripping the clear solution into aluminum species, stirring, placing into a reactor for hydrothermal crystallization, cooling, vacuum filtering, drying, and calcining to obtain the mesoporous LTA zeolite. The obtained mesoporous LTA zeolite crystals have microporous and mesoporous dual-model pore distribution, combines the pore channel advantage of a mesoporous material and strong acidity and high hydrothermal stability of microporous molecular sieves, and has unique ordered mesoporous channels, and have a wide application prospect in the fields of catalysis, adsorption and separation, etc. The invention has the advantages of easiness in operation and low raw material cost, and is suitable for large-scale production, etc.

The invention discloses a cellulose acetate nano composite material with ultraviolet shielding and bacteriostatic properties and a preparation method thereof. The cellulose acetate nano composite material is composed of the following components by weight: 96-99.5 parts of cellulose acetate and 0.5-4 parts of copper complex modified halloysite. The copper complex modified halloysite is used as a modifier, so that the performance of the cellulose acetate can be effectively improved. The cellulose acetate nano composite material prepared by the invention has excellent ultraviolet shielding performance, bacteriostatic performance, thermal stability, water vapor barrier property, low hygroscopicity and low cytotoxicity, can keep high optical transparency, and is simple in preparation process, environment-friendly, low in cost, suitable for large-scale production, and has good application prospects in the fields of packaging, ultraviolet protection and the like.

The invention belongs to the technical field of advanced materials, and particularly relates to a hollow TiO2@C composite microsphere and a preparation method thereof. The preparation method comprisesthe following steps: dispersing silicon dioxide nanospheres in an organic solvent containing a surfactant and an alkali catalyst under the action of ultrasonic waves, adding a titanium source, and carrying out hydrolysis and polycondensation to obtain a SiO2@TiO2 core-shell structure compound; dispersing the compound into a strong alkali solution, and carrying out hydrothermal etching assisted crystallization to obtain titanate with a hollow structure; and finally, dispersing titanate into a carbon source aqueous solution, carrying out hydrothermal reaction, and roasting in an inert atmosphere to obtain the hollow TiO2@C composite microspheres constructed by the nanosheets. The composite microsphere has a double-shell hollow structure, and has large specific surface area, pore volume andpore diameter. The material is applied to a negative electrode of a sodium-ion battery, and shows excellent rate capability and pseudocapacitance characteristic. The raw materials are easy to obtain,the method is simple, and the product has wide application prospects in the fields of environment, energy, catalysis and the like.

Methods of preparing plant-derived proteins or suprastructure proteins, are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized proteins, or suprastructure proteins, producing a protoplast / spheroplast fraction and apoplast fraction from the plant or plant matter, and recovering the apoplast fraction. The apoplast fraction comprises plant-derived proteins or suprastructure proteins. Alternatively, the proteins, or suprastructure proteins, may be obtained from plant or plant matter comprising plant-derived proteins or suprastructure proteins, by digesting the plant matter using a cell wall degrading enzyme composition to produced a digested fraction. The digested fraction is filtered to produced a filtered fraction, and the plant-derived proteins or suprastructure proteins, are recovered from the filtered fraction.

The invention provides a polyvinyl alcohol-acorn starch-gulcomannan composite material and a preparation method thereof. The polyvinyl alcohol-acorn starch-gulcomannan composite material comprises, by weight, 36-48 parts of polyvinyl alcohol, 15-25 parts of acorn starch, 8-16 parts of gulcomannan, 2-5 parts of quaternary ammonium salt, 2-5 parts of talc, 1-3 parts of aluminum oxide, 1-2 parts of saccharin and 1-2 parts of plasticizer. The preparation method comprises the steps that (1) the raw materials except the polyvinyl alcohol are added into water, heating is performed for a reaction, and filtering and drying are performed for standby use; (2) obtained solid is dissolved and dispersed into N,N-dimethylformamide to form a suspension, and the suspension is placed in a standing mode for standby use; (3) the polyvinyl alcohol is added into the suspension, the suspension is kept at the temperature ranging from 40 DEG C to 60 DEG C for 6-8 h, glass is coated with a film through a tape casting method, and vacuum drying at the constant temperature is performed to obtain the polyvinyl alcohol-acorn starch-gulcomannan composite material. The obtained polyving akohol-acorn starch-gulcomannan composite material has higher tensile strength and bending strength and is lower in cost, the preparation technology is simple, and the polyvinyl alcohol-acorn starch-gulcomannan composite material is suitable for large scale production.

The invention belongs to the technical field of polymer composite materials, and relates to a multifunctional polyvinyl alcohol nano composite material and a preparation method thereof. The multifunctional polyvinyl alcohol nano composite material is prepared from the following raw materials: polyvinyl alcohol and modified cellulose nanocrystals. The invention also provides a preparation method of the multifunctional polyvinyl alcohol nano composite material. The prepared multifunctional polyvinyl alcohol nano composite material has excellent ultraviolet shielding performance, antibacterial performance, ammonia response performance, mechanical performance, water vapor permeability and thermal stability. Meanwhile, high optical transparency can be kept, the preparation process is simple, environmentally friendly and low in cost, and the multifunctional polyvinyl alcohol nano composite material is suitable for large-scale production, and has good application prospects in the fields of packaging, ultraviolet protection and the like.

The invention relates to a preparation method of a composite bone tissue engineering stent material. The preparation method comprises the following steps: 1) preparing zinc ion sustained-release hydroxyapatite; 2) adding the zinc ion sustained-release hydroxyapatite obtained in the step 1) to a chitosan solution, stirring and mixing uniformly and adjusting the pH to obtain a chitosan / hydroxyapatite suspension; 3) slowly adding the suspension obtained in the step 2) to a silk fibroin solution to obtain a mixture; 4) injecting the mixture obtained in the step 3) into a mold, conducting freeze drying, immersing the mold in an anhydrous methanol and sodium hydroxide solution h, rinsing with deionized water and conducting freeze drying again to obtain a final composite stent material. The composite bone tissue engineering stent material has good biocompatibility, degradable controllability and good formability, and can be used for treating bone defects.

The invention provides a method for synthesizing tiagabine hydrochloride, which has the following synthesizing route. The invention also provides a method for preparing anhydrous tiagabine hydrochloride of medicinal preparation level in a single or mixed organic solvent. An important dithiophene N-alkylated intermediate is prepared by the compact synthesizing method; and the synthesizing route does not need expensive special reagents, is convenient to operate, has mild reaction conditions, and is suitable for expanded preparation. In addition, when the anhydrous tiagabine hydrochloride is prepared by adopting the single or mixed organic solvent, the residual organic solvent is tried to remove so that the anhydrous tiagabine hydrochloride meets the requirement of a medicament preparation.

The invention provides a technology for fermenting halostachys caspica metallothionein and an application of the halostachys caspica metallothionein. The technology includes the steps that a recombination expression transformant in the prior art is cultivated at the temperature of 37 DEG C for staying overnight and then is inoculated to an improved fermentation medium at the proportion of 2%, fermentation is conducted in a full-automatic fermentation tank, and the liquid containing coefficient is 0.5; overall sterilization is carried out after an antifoaming agent is added, the ventilatory capacity is 1 L / min, the temperature is kept to be 37 DEG C, the rotating speed of stirring is 100 r / min, lactose with the concentration being 6 mmol / L is added for inducing after fermentation is conducted for 4 hours, and fermentation liquor is centrifuged for 10 minutes at the rotating speed of 8000 rpm after fermentation continues for 4 hours so that thalli can be obtained; then PBS is used for washing and centrifuging three times, the thallus dry weight of the halostachys caspica metallothionein is subjected to constant-weight weighing after drying is performed for 1.5 hours at the temperature of 105 DEG C, and the obtained thallus quantity is increased by 31% compared with shake-flask culture. By means of the technology for fermenting the halostachys caspica metallothionein and the application of the halostachys caspica metallothionein, the yield of the halostachys caspica metallothionein can be greatly increased, and the technology is suitable for large-scale industrial production and has wide significance to the application field of the metallothionein.

A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding chimeric influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

The invention belongs to the technical field of advanced nanocomposite materials, and in particular relates to a mesoporous / macroporous composite carbon material with a multi-level ordered structure and a preparation method thereof. In the present invention, the colloidal crystal of silica mold is used as the hard template, the block copolymer surfactant of the polyoxyethylene segment is used as the soft template, and the phenolic resol resin is used as the carbon source. Synthesis of mesoporous / macroporous composite carbon materials with hierarchical channels. The material not only has interconnected ordered macropores but also short-range ordered mesoporous walls. In addition, this type of material has an optical band gap produced by a colloidal crystal structure, and the band gap wavelength is continuously adjustable. The material has broad application prospects in optical waveguides, sensors, and catalyst carriers. The method of the invention is simple, the raw material is easy to obtain, and is suitable for scale-up production.

The invention discloses a preparation method for 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-indole as shown in the specification. The preparation method comprises the following steps: (1) subjecting a compound II and a compound III to a condensation reaction in an alcohol solvent under the action of alkali; and (2) mixing a reaction solution obtained in the step (1) with protonic acid and carrying out Bischler-Mohlau indole cyclization. Compared with the prior art, the invention has the following advantages: the condensation reaction in the first step and Bischler-Mohlau indole cyclization at the second step are integrated into a one-pot reaction, so operation is simple and convenient; a reaction product I is directly precipitated from the reaction solvent, so reaction post-treatment is substantially simplified, and high purity and high reaction yield are realized; and the method is applicable to enlarged production.

A composite hollow fibre membrane based on the composite resistance Henis membrane model (silica rubber / polysulfone membrane) for separating H2 or N2 with high effect is composed of basic membrane, water-soluble high-molecular layer in rubber state at ordinary temp and silica rubber layer. It can be used for the ammonia synthesizing plant or oil refinary to recover N2 or H2. Its preparing process is also disclosed.

Methods of recovering plant-derived proteins or suprastructure proteins, are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized proteins, or suprastructure proteins, loosening the cell wall to produce a plant or plant matter having a loosened cell wall, thus allowing the release of apoplastic content through the cell wall to produce an apoplastic content fraction from the plant or plant matter, and recovering the apoplastic content fraction. The apoplastic content fraction comprises plant-derived proteins or suprastructure proteins.