3results about How to "Good hypoglycemic activity" patented technology

This invention belongs to the technical field of pharmaceuticals, health foods, and medicines, specifically relating to Russula polysaccharide, its extraction method, and its application in anti-inflammatory, antioxidant, and / or hypoglycemic effects. This invention employs an ultrasound-assisted enzymatic hydrolysis method to extract Russula polysaccharide, thereby significantly improving extraction efficiency, reducing enzyme dosage, protecting the polysaccharide structure, and increasing yield and purity. Furthermore, experimental verification shows that it possesses good anti-inflammatory, antioxidant, and / or hypoglycemic effects, and when combined with Phyllanthus emblica polysaccharide, it synergistically enhances hypoglycemic performance, thus demonstrating significant practical application value.

This invention discloses a 5-selenyl-glucosylated apigenin derivative with multi-target hypoglycemic activity. It has the structure described in Formula I. The 5-selenyl-glucosylated apigenin derivative prepared by this invention, by embedding 5-Se-glucose to modify apigenin, becomes an antidiabetic drug. Activity tests show that the 5-selenyl-glucosylated apigenin derivative inhibits the activity of α-amylase and α-glucosidase better than acarbose, and its ability to inhibit DPP4 activity is significantly stronger than that of citalagnin; animal experiments show that the 5-selenyl-glucosylated apigenin derivative has significantly better hypoglycemic activity than acarbose.

The application discloses an egg yolk-derived hypoglycemic peptide as well as a preparation method and application thereof, and belongs to the technical field of polypeptides. The amino acid sequence of the egg yolk-derived hypoglycemic peptide is YVIQEDR. The application identifies a novel hypoglycemic peptide YVIQEDR from defatted egg yolk powder hydrolysate by using a molecular docking technology. It is verified that the hypoglycemic activity of the peptide YVIQEDR is stronger than that of the defatted egg yolk powder hydrolysate. In addition, the YVIQEDR has the advantages of non-toxicity, high safety, strong activity and the like, can be used as an ideal hypoglycemic effective factor, can be widely used in the fields of food, health products, medicine and the like, and has great application value.