10results about How to "Good hypoglycemic activity" patented technology

The invention relates to an extraction and purification method of green tea cell wall polysaccharide with hypoglycemic activity and the obtained green tea cell wall polysaccharide. The green tea is extracted by using water, CDTA, saturated sodium carbonate, 1M NaOH solution and 4M NaOH solution through a sequential extraction method to obtain five different tea polysaccharides; the green tea cell wall polysaccharide with the best hypoglycemic activity is screened out through activity inhibition of glycometabolism enzyme, and is further purified by gel column chromatography. Compared with the prior art, the method has the advantages that the reaction conditions in the whole operation process are mild, the activity of the green tea cell wall polysaccharide can be reserved to the greatest extent, the loss of polysaccharide components is reduced to the greatest extent, the extraction rate is high, the energy consumption is low, the solvent dosage is small, the operation is simple, and the economic cost is low; a foundation is laid for researching the physicochemical property and biological activity of the green tea cell wall polysaccharide, and the method has important significance on utilization of the green tea cell wall polysaccharide in the fields of food, medical care, cosmetics and the like.

The invention belongs to the field of black tea, and particularly relates to large-leaf black tea and a preparation method thereof. The big-leaf black tea comprises the following components in parts by weight: 0.5-1.5 parts of pericarpium citri reticulatae, 1-3 parts of folium eriobotryae, 1-3 parts of partridge tea leaves and 10-20 parts of big-leaf tea. According to the big-leaf black tea disclosed by the invention, the pericarpium citri reticulatae, the folium eriobotryae and the partridge tea leaves are selected to be compatible with the Hainan big-leaf tea, after fermentation, the fragrance of the Hainan big-leaf tea can be improved, the taste of the Hainan big-leaf tea is enriched, the hypoglycemic activity of the Hainan big-leaf tea is improved, meanwhile, the characteristics of the Hainan big-leaf black tea are reserved, and the product of the Hainan big-leaf black tea is enriched; and a new thought is provided for development of related products of Hainan big-leaf black tea.

This invention belongs to the technical field of pharmaceuticals, health foods, and medicines, specifically relating to Russula polysaccharide, its extraction method, and its application in anti-inflammatory, antioxidant, and / or hypoglycemic effects. This invention employs an ultrasound-assisted enzymatic hydrolysis method to extract Russula polysaccharide, thereby significantly improving extraction efficiency, reducing enzyme dosage, protecting the polysaccharide structure, and increasing yield and purity. Furthermore, experimental verification shows that it possesses good anti-inflammatory, antioxidant, and / or hypoglycemic effects, and when combined with Phyllanthus emblica polysaccharide, it synergistically enhances hypoglycemic performance, thus demonstrating significant practical application value.

The invention discloses caffeoside with hypoglycemic activity as well as a preparation method and application of the caffeoside. The preparation method of the caffeoside comprises the following steps: (1) taking roasted coffee beans, and extracting with hot water to obtain a hot water extract; (2) suspending the hot water extract in water, and extracting with ethyl acetate to respectively obtain an ethyl acetate extract and a water layer; (3) extracting the water layer with n-butyl alcohol to obtain an n-butyl alcohol extract; (4) carrying out silica gel column chromatography on the n-butyl alcohol extract, carrying out gradient separation and elution by using a mobile phase CH2Cl2 / MeOH with the volume ratio of (30: 1)-(1: 1), respectively collecting separated fractions with the volume ratios of CH2Cl2 / MeOH of (30: 1), (20: 1), (10: 1), (5: 1) and (1: 1), concentrating to obtain extractum of five fractions, and respectively marking the extractum as Fr.A, Fr.B, Fr.C, Fr.D and Fr.E; and (5) the Fr.D is separated and purified again through reverse silica gel PR-C18 column chromatography, and the caffein is obtained. The method has the advantages that the caffeoside extracted from the hot water of the coffee has high hypoglycemic activity, and the preparation method is simple and feasible.

This invention discloses a 5-selenyl-glucosylated apigenin derivative with multi-target hypoglycemic activity. It has the structure described in Formula I. The 5-selenyl-glucosylated apigenin derivative prepared by this invention, by embedding 5-Se-glucose to modify apigenin, becomes an antidiabetic drug. Activity tests show that the 5-selenyl-glucosylated apigenin derivative inhibits the activity of α-amylase and α-glucosidase better than acarbose, and its ability to inhibit DPP4 activity is significantly stronger than that of citalagnin; animal experiments show that the 5-selenyl-glucosylated apigenin derivative has significantly better hypoglycemic activity than acarbose.

The invention provides cortex cinnamomi milk tea with a low glycemic index and a preparation method of the cortex cinnamomi milk tea, and belongs to the technical field of food processing. The cinnamon milk tea provided by the invention comprises the following raw materials in parts by weight: 0.2-1.0 part of cinnamon active extract, 0.4-1.2 parts of tea powder, 12-20 parts of milk powder, 0-4 parts of white granulated sugar and 100 parts of water. According to the invention, a water extraction and secondary alcohol precipitation method is adopted to extract active substances of cinnamon, and the cinnamon active extract which contains cinnamon polysaccharide and cinnamyl saponin with small polarity and has strong hypoglycemic activity is obtained. The obtained cinnamon milk tea is high in sensory score, belongs to food with a low glycemic index, has a wide application prospect, and is expected to obtain relatively good economic benefits.

The invention relates to the technical field of peptide extraction, in particular to a pig blood hypoglycemic peptide as well as a preparation method and application thereof. The preparation method comprises the following steps: freezing and thawing pig blood, carrying out pig blood denaturation treatment, carrying out two-step enzymolysis, and purifying to obtain the pig blood glucose-reducing peptide. The two-step enzymolysis comprises the following steps: firstly adding alkaline protease into the pig blood solution with the enzyme addition amount of 8000-10000 U / g, reacting for 3-6 hours under the conditions that the pH is 7.5-9.0 and the temperature is 45-55 DEG C, performing enzyme deactivation and cooling, then adjusting the pH to 6-7, then adding compound protease with the enzyme addition amount of 3000-5000 U / g, reacting for 1-4 hours under the condition that the temperature is 45-55 DEG C, performing enzyme deactivation and cooling, and adjusting the pH to 4.5-5.0 to obtain a compound enzymatic hydrolysate A; the purification treatment comprises the step of sequentially performing ultrafiltration by using ultrafiltration membranes of 10KDa, 5KDa and 3KDa. The pig blood glucose-reducing peptide prepared by the preparation method disclosed by the invention is high in yield and good in inhibition rate on alpha-glucosidase and alpha-amylase.

The application discloses an egg yolk-derived hypoglycemic peptide as well as a preparation method and application thereof, and belongs to the technical field of polypeptides. The amino acid sequence of the egg yolk-derived hypoglycemic peptide is YVIQEDR. The application identifies a novel hypoglycemic peptide YVIQEDR from defatted egg yolk powder hydrolysate by using a molecular docking technology. It is verified that the hypoglycemic activity of the peptide YVIQEDR is stronger than that of the defatted egg yolk powder hydrolysate. In addition, the YVIQEDR has the advantages of non-toxicity, high safety, strong activity and the like, can be used as an ideal hypoglycemic effective factor, can be widely used in the fields of food, health products, medicine and the like, and has great application value.

The invention discloses a lysimachia christinae hance oligosaccharide with hypoglycemic activity and an extraction method and application thereof, and is characterized in that the W1-2 oligosaccharide mainly comprises the following monosaccharides: 29.73% of glucose, 23.47% of arabinose, 18.43% of glucosamine, 11.1% of galactose, 7.91% of fructose, 6.82% of mannose and 2.54% of galactosamine. The W2-2 oligosaccharide is mainly composed of the following monosaccharides: 86.95% of glucose, 7.39% of arabinose, 3.53% of galactose, 1.28% of mannose and 0.85% of fructose, and the preparation method comprises the following steps: adding a peach fruit polysaccharide crude extract into pure water for extraction, and carrying out alcohol precipitation overnight to obtain the peach fruit crude polysaccharide; the preparation method comprises the following steps: separating and purifying the lysimachia capillipes hemsl polysaccharide and then separating by an ultrafiltration tube to obtain two high-activity lysimachia capillipes hemsl oligosaccharides, and the lysimachia capillipes hemsl oligosaccharides have the advantages of low molecular weight, strong water solubility, high purity and

The invention relates to the technical field of active ingredient extraction and application, and discloses a preparation method of a traditional Chinese medicine preparation for reducing blood sugar, which comprises the following steps: filtering and centrifugally separating papaya milk cut from papaya green fruits, and collecting supernatant liquid to obtain pretreated papaya milk; enabling the pretreated papaya milk to pass through an ultrafiltration membrane system with the molecular weight of 40000-55000Dal, and collecting milk penetrating through an ultrafiltration membrane; enabling the milk to pass through an ultrafiltration membrane system with the molecular weight of 15000-30000 Dal, and collecting the milk intercepted by an ultrafiltration membrane; performing multi-stage freeze drying on the ultrafiltration membrane milk to obtain milk powder, and preparing capsules, tablets or granules from the milk powder to obtain the traditional Chinese medicine preparation for reducing blood sugar. The milk powder with high hypoglycemic activity is prepared from the papaya milk as the raw material through filtration, centrifugation and two-stage ultrafiltration membrane treatment, and the milk powder is high in quality and can improve the hypoglycemic effect of the traditional Chinese medicine preparation when being used for preparing the hypoglycemic traditional Chinese medicine preparation.