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Preparation method of Fe3O4/Au composite nanoparticles

A composite nanoparticle and nanoparticle technology, which is applied in the field of preparation of Fe3O4/Au composite nanoparticle, can solve the problems such as no discovery, and achieve the effect of mild reaction conditions, good colloidal stability, and simple synthesis steps

Inactive Publication Date: 2013-06-12
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Retrieval of domestic and foreign literature has not found any information on the preparation of PEI-coated Fe by one-step hydrothermal synthesis. 3 o 4 Synthesis of Au / Au Composite Nanoparticles and Its Applications in In Vivo MR / CT Dual-modality Imaging

Method used

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  • Preparation method of Fe3O4/Au composite nanoparticles
  • Preparation method of Fe3O4/Au composite nanoparticles
  • Preparation method of Fe3O4/Au composite nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Take 60mg of mPEG-COOH, 19.17mg of EDC and 11.51mg of NHS in a reaction flask, add 5mL of ultrapure water to dissolve it, and then react with magnetic stirring for 3h. Dissolve 50mg PEI in 5mL ultrapure water. The activated mPEG-COOH aqueous solution (5 mL) was added dropwise to the above 5 mL PEI aqueous solution, and the reaction was stirred for three days. The reaction mixture was dialyzed against distilled water for three days (6 times, 2 L / time) with a dialysis bag with a molecular weight cut-off of 14,000 to remove by-products and impurities, and the product mPEG-PEI was freeze-dried and stored at -20°C for future use. The mPEG-PEI synthesized above was dissolved in 10 mL of ultrapure water. Add 5.4mL HAuCl 4 solution (30mg / mL), stirred for half an hour. Then add ice-bathed 0.9mL NaBH 4 (45.4mg) solution (ethanol / ultrapure water, v / v=1:2), after continuing to stir for two hours, then dialyzed against distilled water for three days (6 times, 2L / time) with a dia...

Embodiment 2

[0066] Take 0.5mL Fe respectively 3 o 4 -PEI-mPEG-Au (comparative example 3) and Fe 3 o 4 - PEI-Ac-mPEG-Au (Example 1) nanoparticles were lyophilized for thermogravimetric analysis. like image 3Shown is the TG change curve of nanoparticles before and after acetylation. It can be seen from the figure that the weight loss of nanoparticles before acetylation is 15.14% ( image 3 a), The weight loss of nanoparticles after acetylation is 17.71%. After calculation, the TG change of nanoparticles before and after acetylation was 2.57%. This shows that Fe 3 o 4 Acetylation Modification of Au / Au Composite Nanoparticles.

Embodiment 3

[0068] Take 0.1mL Fe respectively 3 o 4 -PEI-mPEG-Au (comparative example 3) and Fe 3 o 4 - PEI-Ac-mPEG-Au (Example 1) nanoparticles were prepared into a 1.5 mL aqueous solution with ultrapure water, and then used to measure surface potential and hydrodynamic diameter (see Table 1). The successful acetylation of nanoparticles was further confirmed by the measurement of Zeta potential. Potential measurements (Table 1) show that Fe 3 o 4 -The surface potential of PEI-mPEG-Au nanoparticles is +27.4mV, after the acetylation reaction, the obtained Fe 3 o 4 -PEI-Ac-mPEG-Au nanoparticles surface potential dropped to +12.8mV. The results showed that the amino groups on the surface of the nanoparticles had been successfully acetylated. However, the surface potential of the nanoparticles did not reach neutrality after acetylation, which may be because some of the amino groups used to stabilize the gold nanoparticles and Fe3O4 nanoparticles on the surface cannot undergo acetylati...

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Abstract

The invention relates to a preparation method of Fe3O4 / Au composite nanoparticles, which comprises the following steps: carrying out PEG modification on PEI; coating the PEI subjected to PEG modification so as to synthesize gold nanoparticles; synthesizing PEI-coated Fe3O4 / Au composite nanoparticles by using a hydrothermal method; and carrying out surface acetylation modification on the PEI-coated Fe3O4 / Au composite nanoparticles. According to the invention, the reaction conditions are mild, and the synthetic steps are simple; and prepared Fe3O4 / Au composite nanoparticles are good in colloidal stability, biocompatibility, T2 relaxation effect and X-ray attenuation properties, and have a potential application value in the field of MR / CT bi-modal imaging diagnosis.

Description

technical field [0001] The invention belongs to the field of preparation of composite nanomaterials, in particular to a Fe 3 o 4 / Au composite nanoparticles preparation method. Background technique [0002] In recent decades, with the continuous development of nanotechnology, various nanoparticles have emerged, especially magnetic Fe3O4 nanoparticles, because of their biocompatibility and special magnetic properties, they can be used in biological There are a wide range of applications in the medical field, such as drug delivery, cell separation, and magnetic resonance imaging. In addition, due to its good chemical stability, catalytic activity, biocompatibility, and special optical properties, gold nanoparticles can be well used in protein detection, photothermal therapy, and in vivo disease diagnosis. However, a single nanoparticle has its own shortcomings and limitations, so finding a suitable method to synthesize multifunctional composite nanoparticles has become the ...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/12A61K49/04
Inventor 沈明武李静超蔡红东史向阳张贵祥郑林丰
Owner DONGHUA UNIV
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