46results about How to "Effective controlled release" patented technology

The invention relates to a T7 peptide-modified active brain targeting nanometer drug delivery system and a preparation method thereof. A T7 peptide (with a sequence of CHAIYPRH) is used as a specificbrain targeting ligand, a PEG-PLGA diblock copolymer is used as a carrier of a nanometer drug delivery system, an insoluble drug molecule is entrapped through an emulsification solvent volatilizationmethod, and the insoluble drug molecule is connected to the T7 peptide through a difunctional NHS-PEG-MAL covalent bond so that the active brain targeting nanometer drug delivery system is constructed. The preparation method has simple processes and mild reaction conditions, utilizes a less amount of an organic solvent, effectively reduces the cytotoxicity of the nanometer carrier material, prolongs the circulation time in the body and improves biocompatibility. The T7 peptide-modified active brain targeting nanometer drug delivery system has strong active targeting ability, greatly improves the efficiency of the nanometer carrier drug passing through the blood-brain barrier, enriches the drug in the lesion tissue, improves the bioavailability of the drug, effectively controls the drug release and has a good application prospect in treatment and diagnosis of ischemic stroke and brain tumors.

The invention discloses a preparation method of photothermal response type composite gel hollow microsphere. Silica solid spheres are used as templates, poly (N-isopropylacrylamide-acrylamide)/silica gel composite microsphere with a core-shell structure can be prepared through surface graft polymerization, and silica templates are etched by hydrofluoric acid to form poly (N-isopropylacrylamide-acrylamide) gel hollow microspheres; by using the poly (N-isopropylacrylamide-acrylamide) gel hollow microsphere as a microreactor, the gold nanorod loaded photothermal response composite gel hollow microspheres can be prepared by in-situ reduction; the photothermal response composite gel hollow microspheres are used in doxorubicin hydrochloride phosphate buffer solution system to achieve the effective controlled releasing of doxorubicin hydrochloride in the conditions of near-infrared light and temperature.

The invention discloses a method of removing sulfanilamide antibacterials and a COD (chemical oxygen demand) from livestock breeding waste water by using micron zero-valent ferrum-activated persulfate. The method comprises the steps of adding 0.007-0.008mol/L persulfate and 0.2-0.3g/L micron zero-valent ferrum, uniformly stirring, and keeping pH (potential of hydrogen) of a reaction system to be 4.5-5.5 for reaction, wherein a mole ratio of micron zero-valent ferrum to persulfate is 1:(1.40-2.10). The method overcomes the disadvantages of a too high reaction rate, a low utilization ratio and the like of a metal ion catalyst, can quickly, efficiently and persistently remove the sulfanilamide antibacterials and the waste water COD from the livestock breeding waste water; reaction conditions are mild; the treatment time is greatly shortened; the technical cost is lowered; and the method has wide application prospects in degradation and removal of the sulfanilamides antibacterials and the COD in the livestock breeding waste water.

The invention discloses an electric suspended conveying system for clothing materials. The electric suspended conveying system comprises a conveying rail, wherein a plurality of clamping and releasing devices are arranged on the conveying rail; material roller wheel hooks are arranged on the clamping and releasing devices; the side of the conveying rail is provided with an automatic dropping and feeding mechanism; the automatic dropping and feeding mechanism is correspondingly provided with a material receiving device; and an outlet of the material receiving device is provided with an output automatic feeding mechanism. The invention further discloses an implementation method for the electric suspended conveying system. The electric suspended conveying system has the characteristics of being simple in structure, low in manufacturing cost, high in production efficiency, low in cost, reliable in performance, high in degree of automation, and the like.

The invention relates to a method for loading doxorubicine (DOX) anti-cancer medicine by laponite (LAP) clay nanoparticles. The method comprises the following steps that (1) LAP water solution is prepared and is mixed with DOX, then, the stirring is carried out, and mixed solution is obtained, wherein the concentration of the DOX in the DOX water solution is 2mg/mL, and the concentration of the LAP in the concentration water solution is 2 to 8mg/mL; and (2) the mixed solution is centrifugally separated, supernate is sucked out, in addition, ultra-pure water is used for washing precipitation, and finally, LAP loaded with DOX is obtained. The method has the advantages that the condition is mild, the process is simple, the product is easy to operate and separate, the LAP/DOX obtained by the method can effectively control the release of DOX, the LAP/DOX anti-tumor activity is obviously improved through being compared with that of the pure DOX, and the application prospects are wide.

The invention discloses preparation and application of a tumor-targeting drug based on unsaturated fatty acid nanoparticles. Carboxyl groups of docosahexaenoic acid and amino groups of amino polyethylene glycol are subjected to a condensation reaction to prepare a micelle mPEG-DHA; carboxyl groups of DSPE-PEG-COOH and amino groups of Anti-HER2 are subjected to a condensation reaction to prepare amicelle DSPE-PEG-Anti-HER2; the micelle mPEG-DHA, the micelle DSPE-PEG-Anti-HER2, pyropheophorbide-a methyl ester and adriamycin are subjected to self-assembly to obtain the targeting nanoparticles DPSPAH/MPPa/DOX used for lipid peroxidation and photodynamic-chemotherapy combined tumor therapy. The nanoparticles DPSPAH/MPPa/DOX have a particle size of about 190 nanometers and good stability, can effectively control the release of chemotherapeutic drugs, have good biocompatibility, high efficiency, low toxicity and higher application prospects in the fields of nano drug carriers and nano drug tumor treatment.

The invention relates to a preparation method of a coated controlled-release compound fertilizer, which comprises preparation of a coating solution and coating of compound fertilizer granules. The preparation method comprises the following steps: in combination with common granulation equipment, under specific process conditions, synthesizing a fertilizer coating layer by taking degradable high molecular soil conditioner polyvinyl alcohol, natural high molecular starch and fertilizer sustained release agent as main components; and coating a granular compound fertilizer, thus preparing the coated controlled-release fertilizer integrating the functions of simultaneously realizing controlled release of nitrogen, phosphorus and potassium nutrients, having a degradable coating layer, improving soil and the like. The fertilizer efficiency duration is up to 60-100 days; the single-dose application of the fertilizer can satisfy the requirements of crops for nutrients during the whole growing season; and the loss of the fertilizer is effectively decreased, and the utilization ratio of the fertilizer is increased. The coating layer can be biologically degraded within 100 days; and the degraded components are harmless and non-toxic, and effectively improve the soil structure. Besides, the compound fertilizer is accessible in raw materials, simple in processing technique, low in cost and convenient to produce and use.

The invention relates to controlled-release fertilizer as well as a preparation method and application thereof. The controlled-release fertilizer is prepared by taking straw powder as a raw material,carrying out sulfonation treatment under the existence of sulfite, a buffer agent, anthraquinone and copper salt, then carrying out alkalization treatment by sodium hydroxide and finally carrying outchloroacetic acid treatment. The invention also provides the preparation method and the application of the controlled-release fertilizer. In the controlled-release fertilizer provided by the invention, the molecular weight of lignin is small, the sulfonating rate is high, and the lignin and cellulose in plant straw are fully utilized; the controlled-release fertilizer can be applied by adding water or be applied as base fertilizer or topdressed fertilizer, a slow release effect is good, and release of nutrients can be effectively controlled.

The invention discloses a Web page data generation method, a WEBITOX server and a Web application system. The method comprises following steps: using an XML page label and the server to control a label-defined WML text; finding a corresponding WML text according to the access requirement of a client and analyzing the WML text and obtaining data corresponding to the access requirement from a Web server database according to the analyzed WMML text content; converting obtained data into an HTML format; and packaging data in the HTML format to send it to the client and display data in the client. The invention further provides the Web server and the Web application system. The Web page data generation method, the Web server and the Web application system provided by the invention have following beneficial effects: seamless connection between the database and the Web server is achieved; development and management of the application system for the database are simplified such that a company can easily transplant applications to the WEB server; access and release of shared data and exclusive data can be effectively controlled and performance of the system is improved and convenience of data access is enhanced.

The invention discloses oligopeptide alcogel or hydroalcoholic gel and a preparation method and application thereof. The oligopeptide alcogel or hydroalcoholic gel is prepared from (a) at least one oligopeptide and a derivative thereof; and (b) at least one lower alcohol and/or polyol. The oligopeptide alcogel/alcogel gel is used as a repairing functional component of washing-free antibacterial gel, can promote skin fibroblast proliferation, and has the effects of healing wounds and inhibiting inflammatory response and injuries, so that the skin barrier balance is maintained from the deep layer of the skin, and irritant injuries to the skin due to long-term use of ethanol antibacterial products are repaired.

The invention discloses a preparation method of a slow-release micropill with mulberry leaf extract, which comprises the following steps: (1) proportionally and evenly mixing a filler, a binder and a lubricant to prepare a smooth spherical blank pill core of 20-30 meshes; (2) preparing the mulberry leaf extract and a high molecular material binder into a mixed solution, and coating the mixed solution at the outer layer of the blank pill core to prepare a quick-release micropill; and (3) dissolving a retarder, a hole former and a plasticizer with a coating solvent, and then, spraying at the outer layer of the quick-release micropill to prepare the slow-release micropill. The weight increment of the slow-release micropill is controlled to be 5-25%. The slow-release micropill prepared by the invention can be effectively controlled to be released in a certain period of time, the effective blood concentration can be maintained for 24 hours, and no burst-release phenomenon occurs, thereby greatly enhancing the effect of the mulberry leaf extract on a human body. The method disclosed by the invention is simple to operate and is easy to realize industrialized production.

The invention discloses a share-type bottom mud plow with a forked-tail-wing plow body. The share-type bottom mud plow comprises a plow wall and a plowshare connected with the plow wall. The guide curve of the plow body is an inward cycloidal path. The plow wall bends inwardly and smoothly from one side connected with the plowshare, and comprises a sweeping-back tail. The tail is in the shape of ashearing wing, and an upper forked tail wing and a lower forked tail wing are formed. The inward bending degree of the upper forked tail wing is larger than that of the lower forked tail wing. The lower forked tail wing is an inward paraboloid. A plowshare tip is arranged at the front end of the plowshare, a plowshare wing is arranged on the rear portion of the plowshare, and a plowshare blade isarranged on one side of the plowshare. The plow wall and the plowshare are connected and fastened by a plurality of flat head bolts. The bottom mud plow is applicable to effective underwater plowingof bottom mud in water bottom mud regions with flat bottoms, and the plowing effect of covering upper bottom mud by lower bottom mud is achieved, so that isolation between pollution-layer bottom mud and overlaying water is realized, the effect of effectively controlling bottom mud pollutant release and killing sedimentary living algae is achieved, and eutrophication of water bodies and disasters such as blue-green algae of the water bodies are reduced.

The invention discloses a nifedipine sustained-release tablet and a preparation method thereof. The nifedipine sustained-release tablet is a double-layer tablet, wherein the outer-layer tablet is prepared from the following raw materials: nifedipine, microcrystalline cellulose, spray-dried lactose, sodium dodecyl sulfate, copovidone, superfine silica powder and magnesium stearate by using a direct powder compression method; and the inner-layer tablet is prepared from the following raw materials: nifedipine, lactose, pregelatinized starch, hydroxypropyl cellulose, sodium alginate, potassium alginate, povidone, PEG6000, polyvinylpyrrolidone and magnesium stearate. The preparation method comprises the steps of preparing a nifedipine dispersoid from nifedipine, povidone and PEG6000 by using a solvent evaporation method; and then, carrying out wet granulation on the nifedipine dispersoid and other raw materials to prepare the inner-layer tablet. The outer-layer tablet of the nifedipine sustained-release tablet is prepared by using the direct powder compression method, so that disintegration is high, and the required blood concentration is rapidly reached within short time; and the inner-layer tablet formed by compounding the hydroxypropyl cellulose, sodium alginate and potassium alginate is used as a gel sustained-release framework and can be completely released within 24h.

The invention relates to the field of slow-release material application, and discloses a preparation method of a green long-acting portable solid fragrance agent. The method comprises the following steps: S1, crushing and drying colloid-grade attapulgite; S2, uniformly mixing the treated colloid-grade attapulgite and essential oil according to a certain proportion to prepare a high-concentration raw material, and uniformly mixing according to another proportion to prepare a low-concentration raw material; S3, pressing the high-concentration raw material into pills at constant pressure; and S4, taking the pills serve as inner cores, placing the low-concentration raw material into the pills to serve as outer shells, ensuring that the inner cores are evenly wrapped in the outer shells, then performing secondary pressing under the constant pressure, and preparing the green long-acting portable solid fragrance agent of the core-shell structure. According to the method, the use of organic auxiliary reagents is completely eradicated, fragrance diffusion equipment assistance is not needed, the fragrance release rate can be adjusted, the long-acting slow release is effectively ensured, the preparation process is simple, the cost is low, the use is green and pollution-free, the essential oil utilization degree is high, the residual oil rate is low, and the VOC pollution is avoided.

The invention discloses secoisolariciresinol diglucoside hydrogel based on soybean protein isolate and carrageenan and a preparation method of the secoisolariciresinol diglucoside hydrogel, and belongs to the technical field of food processing. The method comprises the following steps: (1) dissolving soybean protein isolate powder in water to obtain a hydrated protein solution, then heating to obtain a protein aggregate, and cooling for later use; (2) mixing a secoisolariciresinol diglucoside solution with the protein aggregate, and then adding carrageenan to obtain a pre-gel solution; and (4) adding gluconic acid-delta-lactone into the pre-gel solution to obtain the lignan hydrogel based on the soybean protein isolate and the carrageenan. The gel prepared by the method disclosed by the invention has good water binding capacity, viscoelasticity and capability of controlling the release of lignan.

The invention discloses a core-shell structure nano particle and a preparation method thereof. The core-shell structure nano particle comprises a water phase core and an organic phase shell, wherein the water phase core is composed of an aerogel and a plurality of active drug particles, and the multiple active drug particles are dispersed in the aerogel; and the organic phase shell covers the surface of the water phase core. It is understandable that through the technical scheme of the core-shell structure nano particle, effective controlled release of active drugs can be realized.

The invention discloses a heat-sensitive drug-loaded nano particle based on a conjugated polymer and a preparation method of the heat-sensitive drug-loaded nano particle. The nano particle is a nanoball taking the conjugated polymer coated with an antitumor drug as the core and taking a heat-sensitive polymer as the shell and formed by the conjugated polymer coated with the antitumor drug and theheat-sensitive polymer through hydrophobic interaction. The heat-sensitive drug-loaded nano particle based on the conjugated polymer has the advantages that the biocompatibility and photostability aregood, effective and controllable drug release can be achieved, and a large amount of active oxygen can be generated under the irradiation of white light, so that the synergistic treatment of photodynamic therapy can also be performed while the drug is released; in addition, since the heat-sensitive drug-loaded nano particle has excellent fluorescence properties, the heat-sensitive drug-loaded nano particle can also be used for cell imaging and drug release tracking.

The invention relates to the technical field of sewage treatment and discloses a method for removing bottom mud phosphorus in a polluted water body in situ by a biomass phosphorus-locking agent. The biomass phosphorus-locking agent is prepared from the following components: dehydrated sludge, plant fiber powder, organic kitchen garbage, clinker and shell powder. The biomass phosphorus-locking agent is mixed into bottom mud around root systems of black algae and has a good removal effect on the bottom mud phosphorus of the polluted water body. The biomass phosphorus-locking agent is prepared from fermented sludge and the shell powder; the biomass phosphorus-locking agent is combined with large-size submerged plants to provide the in-situ removal method of the bottom mud phosphorus in the polluted water body. The biomass phosphorus-locking agent can be used for effectively controlling the phosphorus to be released into the water body; meanwhile, solid-state phosphorus of a bottom mud part is converted into plant absorbable phosphorus, and other nutrient substances including nitrogen, mineral elements and the like can be provided for the plants; advantages of a chemical phosphorus-locking method and plant absorption are effectively combined and the aim of efficiently removing the bottom mud phosphorus in situ is realized.

The invention relates to a suture line with a gel coating. A surface of a suture line is partially dissolved to form a melt layer, one end of a part of molecules is free, the other end of the part of molecules is still fixed on the suture line, and then the hydrogel layer is formed on the surface of the suture line through self-crosslinking of the molecules and/or crosslinking of the molecules and other substances, so that the suture line is obtained. The suture line prepared by the invention overcomes problems of weak combination of a coating and a suture line and rough surface of the suture line, can greatly reduce friction and pulling between tissues in a suture process and after the suture process, is convenient for loading drugs, bioactive preparations and the like, effectively delays or releases the loaded substances, and promotes healing of damaged tissues.

The invention relates to a preparation method of a microcapsule phenylethyl alcohol essence, comprising the following steps: (1) weighing 20g of cyclodextrin or its derivative, and dissolving in 100ml of water to prepare a saturated solution; (2) mixing the phenylethyl alcohol essence and cyclodextrin or its derivative according to the ratio of 1:3-1:6, stirring, letting the temperature be 35-45 DEG C, and continuously stirring for 1-2h; and (3) cooling and standing for 24-48h, filtering, and drying substances obtained from the filtering to constant weight. The cyclodextrin or its derivative is cyclodextrin, beta-cyclodextrin, hydroxyethyl-beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin, methylated-beta-cyclodextrin, carboxymethylated cyclodextrin and the like. According to the invention, stability of the phenylethyl alcohol essence is raised, volatilization of effective components is avoided, and release of fragrance components is effectively controlled.

The invention discloses a capsule. According to the capsule, an internal separating plate is arranged in the middle part of the capsule to divide the capsule into two internal cavities; each internalcavity is provided with a small capsule body. Compared with the prior art, the advantages are that: the kind and the amount of medicines in the internal cavities and the small capsule bodies can be adjusted based on the different pathologic conditions of consumers, so that effective controlled release effect is achieved; and the capsule can be divided into two parts by the internal separating plate, so that it is convenient for a consumer to eat only half of the capsule.