Absorbable magnesium alloy stent with polymer and TiO2 nanotube coating and preparation method thereof

Abstract

The invention provides an absorbable magnesium alloy stent with a polymer and TiO2 nanotube coating and a preparation method thereof. The stent comprises a bare magnesium alloy stent backbone and a polymer and TiO2 nanotube composite coating, wherein the surface of the magnesium alloy stent backbone is provided with a TiO2 nanotube drug-loaded anticorrosive coating; and the surface of the TiO2 nanotube coating is provided with a polymer controlled release coating. The preparation method is characterized by preparing the TiO2 nanotube drug-loaded anticorrosive coating on the surface of the magnesium alloy stent backbone by combining plasma surface sputtering technology with an anodic oxidation method and then preparing the polymer controlled release coating by a physical spraying method. The stent and the preparation method have the beneficial effects that the corrosion resistance of the magnesium alloy stent is effectively improved by utilizing the TiO2 nanotube and polymer composite coating; the TiO2 nanotube drug sustained release coating and the polymer drug controlled release coating can be utilized to effectively control drug release; and the stent has potential application prospect in the field of cardiovascular disease treatment.

Description

technical field

[0001] The present invention relates to a kind of polymer TiO 2 An absorbable magnesium alloy stent coated with nanotubes and a preparation method thereof belong to the field of drug eluting stents. Background technique

[0002] Postoperative vascular restenosis has always been a huge challenge for interventional treatment of coronary heart disease. Although stent intervention can open narrowed blood vessels, it will inevitably cause damage to blood vessels, which may cause vascular restenosis. Although drug-coated stents can reduce the restenosis rate to 10% after stent implantation, drug-eluting stents use metal as the base material, such as medical 316L stainless steel, cobalt alloy, nickel-titanium shape memory alloy, etc. Metal stents have good mechanical support performance, but they cannot get rid of some side effects caused by the long-term retention of the metal body, such as thrombosis, persistent physical stimulation, endothelial dysfunction, dela...

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