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Absorbable magnesium alloy stent with polymer and TiO2 nanotube coating and preparation method thereof

A magnesium alloy stent, nanotube technology, applied in coating, medical science, surgery, etc., can solve the problem of multiple coating on stent surface, improve biocompatibility, improve corrosion resistance, and solve the problem of excessive corrosion. Effect

Active Publication Date: 2015-04-08
浙江瓦司特钠科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the surface coating of above-mentioned stent is more

Method used

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  • Absorbable magnesium alloy stent with polymer and TiO2 nanotube coating and preparation method thereof
  • Absorbable magnesium alloy stent with polymer and TiO2 nanotube coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]Magnesium alloy AZ81 (mass fraction is Al (8-8.5%), Zn (0.5-1%), Taiyuan University of Technology) is laser engraved into a vascular stent, and then it is ultrasonically cleaned in a hydrochloric acid solution with a mass concentration of 5%. After 1 hour, it was placed in a cell shaker with a power of 300W, ultrasonically cleaned for 20 minutes, and then vacuum-dried. The Ti-4Zr alloy coating was prepared on the dry surface of the magnesium alloy stent by plasma surface sputtering method, the used targets were titanium target and copper target, the atmosphere was argon, and the sputtering time was 30 minutes.

[0033] Then, TiO was prepared on the surface of magnesium alloy Ti-4Zr coating by anodic oxidation method. 2 Nanotubes, the electrolyte composition is glycerol-water (1:2vol.%) / 0.1M NH 4 F, the oxidation time is 0.5-6h, and the oxidation voltage is 5V. Then hang the bracket after cleaning and immerse it in an acetone solution with a mass concentration of paclit...

Embodiment 2

[0037] Experimental conditions and operation steps of embodiment 2 are exactly the same as embodiment 1, just prepare TiO in anodic oxidation 2 In the process of nanotube coating, change the anodizing voltage to 10V, 15V, 20V, 25V, 30V, 35V, 40V, 45V, 50V.

[0038] Cytotoxicity tests showed that the prepared polymer TiO 2 Nanotube-coated absorbable magnesium alloy stents have good biocompatibility. Soak the prepared stent in Hank's dynamic simulated body fluid for different time and test the corrosion rate of drug and magnesium alloy. The drug release results show that the drug release rate is 40%-50% in 90 days, and the drug release is slow. The magnesium alloy corrosion test results show that Metal stents were basically degraded in 400-500 days.

Embodiment 3

[0040] Experimental conditions and operation steps of embodiment 3 are exactly the same as embodiment 1, just prepare TiO in anodic oxidation 2 In the process of nanotube coating, the composition of the anodic oxidation electrolyte was changed to glycerol-water (1: 2vol.%) / 0.2M NH 4 F and glycerol-water (1:2vol.%) / 0.3M NH 4 F.

[0041] Cytotoxicity tests showed that the prepared polymer TiO 2 Nanotube-coated absorbable magnesium alloy stents have good biocompatibility. Soak the prepared stent in Hank's dynamic simulated body fluid for different time and test the corrosion rate of drug and magnesium alloy. The drug release results show that the drug release rate is 35% in 90 days, and the drug release is slow. The magnesium alloy corrosion test results show that the metal stent is in After 340 days, the degradation is basically completed.

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Abstract

The invention provides an absorbable magnesium alloy stent with a polymer and TiO2 nanotube coating and a preparation method thereof. The stent comprises a bare magnesium alloy stent backbone and a polymer and TiO2 nanotube composite coating, wherein the surface of the magnesium alloy stent backbone is provided with a TiO2 nanotube drug-loaded anticorrosive coating; and the surface of the TiO2 nanotube coating is provided with a polymer controlled release coating. The preparation method is characterized by preparing the TiO2 nanotube drug-loaded anticorrosive coating on the surface of the magnesium alloy stent backbone by combining plasma surface sputtering technology with an anodic oxidation method and then preparing the polymer controlled release coating by a physical spraying method. The stent and the preparation method have the beneficial effects that the corrosion resistance of the magnesium alloy stent is effectively improved by utilizing the TiO2 nanotube and polymer composite coating; the TiO2 nanotube drug sustained release coating and the polymer drug controlled release coating can be utilized to effectively control drug release; and the stent has potential application prospect in the field of cardiovascular disease treatment.

Description

technical field [0001] The present invention relates to a kind of polymer TiO 2 An absorbable magnesium alloy stent coated with nanotubes and a preparation method thereof belong to the field of drug eluting stents. Background technique [0002] Postoperative vascular restenosis has always been a huge challenge for interventional treatment of coronary heart disease. Although stent intervention can open narrowed blood vessels, it will inevitably cause damage to blood vessels, which may cause vascular restenosis. Although drug-coated stents can reduce the restenosis rate to 10% after stent implantation, drug-eluting stents use metal as the base material, such as medical 316L stainless steel, cobalt alloy, nickel-titanium shape memory alloy, etc. Metal stents have good mechanical support performance, but they cannot get rid of some side effects caused by the long-term retention of the metal body, such as thrombosis, persistent physical stimulation, endothelial dysfunction, dela...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/16A61L31/10A61L31/08A61L31/02
Inventor 郭美卿戴震陈静黄棣史振东梅华
Owner 浙江瓦司特钠科技有限公司
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