Controlled-release pellet for treating acute and chronic hepatitis and preparation method and application thereof

A slow-release pellet, acute and chronic technology, applied in the field of medicine, can solve the problems of short dosing time interval, inconvenient for patients to use, large dosage, etc., achieve high yield and reproducibility, and enhance the effect of the human body, the method Simple to use effects

Inactive Publication Date: 2013-07-24
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical use, the daily dosage is large and the number of administrations is many, which is inconvenient for patients, especially for patients who take long-term medication; and the administration time interval is short, the effective blood drug concentration fluctuates greatly, and the bioavailability is low

Method used

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  • Controlled-release pellet for treating acute and chronic hepatitis and preparation method and application thereof
  • Controlled-release pellet for treating acute and chronic hepatitis and preparation method and application thereof
  • Controlled-release pellet for treating acute and chronic hepatitis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of traditional Chinese medicine extract

[0038] Take 40g of weeping grass, 40g of Gynostemma pentaphyllum, 25g of sealwort, 20g of capillary, 15g of Citrus aurantium, 15g of phylloxera, 20g of malt, 20g of white peony, add 8 times the amount of distilled water to extract twice, each time for 1.5 hours, and combine the extracts , concentrated to 0.4ml / g crude drug, add ethanol to make the alcohol content reach 80%, let it stand for 8 hours, filter with suction, and get the supernatant. Pass the liquid medicine through a D1010 macroporous adsorption resin column, wash with water until colorless, elute with 90% ethanol, collect 10BV of the eluate, and evaporate to dryness to obtain the total flavonoids and total saponins; Concentrate the washing liquid after passing through the macroporous resin, Adjust the pH value of the medicinal solution to 2, apply 732 type cation exchange resin, wash with water until colorless, elute with 40% ethanol containing 3% ammoni...

Embodiment 2

[0040] Take 20g of weeping grass, 60g of Gynostemma pentaphyllum, 10g of sealwort, 30g of capillary, 5g of Citrus aurantium, 25g of phylloxera, 10g of malt, 30g of white peony, add 12 times the amount of distilled water to extract three times, each time for 1 hour, and combine the extracts, Concentrate to 0.8ml / g crude drug, add ethanol to make the alcohol content reach 60%, let it stand for 10 hours, filter with suction, and get the supernatant. Pass the liquid medicine through a D1010 type macroporous adsorption resin column, wash with water until colorless, elute with 70% ethanol, collect 8BV of the eluate, and evaporate to dryness to obtain the total flavonoids and total saponins; Concentrate the washing liquid after passing through the macroporous resin, Adjust the pH value of the medicinal solution to 4, apply 732 type cation exchange resin, wash with water until colorless, elute with 80% ethanol containing 8% ammonia water, collect the eluate, and evaporate to dryness to...

Embodiment 3

[0042] Take 60g of weeping grass, 10g of Gynostemma pentaphyllum, 40g of sealwort, 10g of capillary, 25g of Fructus aurantium, 1g of phylloxera, 25g of malt, 5g of white peony, add 12 times the amount of distilled water to extract three times, each time for 1 hour, and combine the extracts, Concentrate to 0.8ml / g crude drug, add ethanol to make the alcohol content reach 60%, let it stand for 10 hours, filter with suction, and get the supernatant. Pass the liquid medicine through a D1010 type macroporous adsorption resin column, wash with water until colorless, elute with 70% ethanol, collect 8BV of the eluate, and evaporate to dryness to obtain the total flavonoids and total saponins; Concentrate the washing liquid after passing through the macroporous resin, Adjust the pH value of the medicinal solution to 4, apply 732 type cation exchange resin, wash with water until colorless, elute with 80% ethanol containing 8% ammonia water, collect the eluate, and evaporate to dryness to...

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Abstract

The invention relates to a controlled-release pellet for treating acute and chronic hepatitis. The controlled-release pellet consists of a blank pellet, a medicament carrying layer and a controlled-release layer, wherein the medicament carrying layer consists of a Chinese medicinal extract and a medicinal adjuvant; the Chinese medicinal extract is prepared from the following raw materials in parts by weight: 20-60 parts of sedum sarmentosum, 10-60 parts of gynostemma pentaphylla, 10-40 parts of sealwort, 10-30 parts of capillary wormwood, 5-25 parts of fructus aurantii, 1-25 parts of common leaf flower herb, 10-25 parts of malt and 5-30 parts of white peony root; and the weight ratio of the blank pellet to the medicament carrying layer to the controlled-release layer is (1.5-7.5): (2-6.5): (0.5-3). The controlled-release pellet can effectively control the medicaments to release within a certain period of time, hold 12h effective blood concentration and avoid dumping phenomenon, therefore, the action on a human body is greatly enhanced. The method is easy to operate and is beneficial to industrialized production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a medicine for treating acute and chronic hepatitis and a preparation technology for a sustained-release preparation of the medicine, more specifically, to a sustained-release pellet for treating acute and chronic hepatitis, a preparation method and application thereof. Background technique [0002] Viral hepatitis is highly contagious, difficult to cure, and easy to relapse. my country is a high-incidence area of ​​viral hepatitis and liver cancer. Due to factors such as deteriorating living environment and frequent population flow, the incidence rate continues to rise. At present, there are many anti-hepatitis drugs at home and abroad, and new anti-hepatitis drugs of traditional Chinese medicine are emerging one after another, but the real curative effect is reliable, the quality is stable, the onset of effect is fast, the use is convenient, the toxicity and side effects are sma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61K9/16A61P1/16
Inventor 严国俊潘金火蒋志涛毛敏珏张婷葛少波侯振山
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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