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Preparation method for carbon-coated ferroferric oxide nano-shell-loaded nano gold particles

A technology of carbon-coated ferric oxide and nano-gold particles, which is applied in the field of nanomaterials, can solve the problems of low drug loading, poor controlled release effect, and limited application fields, and achieve appropriate gold loading and high drug loading. rate, the effect of increasing the drug loading rate

Inactive Publication Date: 2019-01-04
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] This patent proposes a new type of carbon-coated four Preparation method of ferric oxide nanoshell loaded nano gold

Method used

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  • Preparation method for carbon-coated ferroferric oxide nano-shell-loaded nano gold particles
  • Preparation method for carbon-coated ferroferric oxide nano-shell-loaded nano gold particles
  • Preparation method for carbon-coated ferroferric oxide nano-shell-loaded nano gold particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] First step, Fe 3 o 4 Preparation of nanoshells:

[0030] (1) Weigh 0.8g of sodium dodecylbenzenesulfonate (SDBS) and dissolve it in 80mL of ethylene glycol (EG), stir magnetically for 30min until dissolved.

[0031] (2), weigh 2.7g ferric trichloride hexahydrate (FeCl 3 ·6H 2O) Dissolve in the above solution and stir magnetically for 30 min.

[0032] (3) Dissolve 4.65 g of sodium acetate (NaAc) in the above solution and stir for 1 h.

[0033] (4) Pour the above solution into a 100mL polytetrafluoroethylene-lined reactor, put it into a resistance oven at 180°C to react for 12 hours, and cool naturally.

[0034] (5) The black precipitate was collected by centrifugation, washed 3 times with deionized water, and then washed 3 times with absolute ethanol, dried in a vacuum oven at 60°C, ground and collected for later use. During the washing process, the centrifugation speed is 6000r / min, and the time is 8min.

[0035] The second step, carbon coated Fe 3 o 4 Preparat...

Embodiment 2

[0046] The difference from Example 1 is that the amount of sodium acetate (NaAc) is 5.65 g.

Embodiment 3

[0048] The difference from Example 1 is that the amount of sodium acetate (NaAc) is 6.65g.

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Abstract

The invention discloses a preparation method for carbon-coated ferroferric oxide nano-shell-loaded nano gold particles. The method is capable of, according to an Ostwald ripening theory, and through aferroferric oxide nano-shell prepared by using a soft template method in advance, using glucose as a carbon source and performing hydrothermal coating, finally loading nanogold by using a chemical reduction method. The obtained ferroferric oxide nano-shell is a carbon-coated ferroferric oxide hollow-core nano-shell. Compared with a solid nano-shell, the carbon-coated ferroferric oxide hollow-corenano-shell is large in specific surface area, and high in drug loading ratio. On the other hand, a shell structure is capable of controlling burst release of a drug so as to achieve a purpose of slowrelease.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a preparation method and application of nano-gold particles coated with carbon-coated ferric oxide nanoshells. Background technique [0002] Nowadays, with the continuous development of nanotechnology, a single nanomaterial cannot fully meet people's requirements for materials, so two or more materials are compounded to obtain the materials people want to achieve the required purpose. . Combination of materials can make comprehensive use of the properties of each material itself, so that it has a variety of properties. Because of its crystal structure and composition, trioxide tetroxide has superparamagnetism and targeting, so it can be applied to biological drug loading. And because iron ions are an important part of the human body, when Fe 3 o 4 When used as a drug-loaded carrier, compared with other magnetic materials, it is conducive to cell phagocytosis, absorption...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/08C01B32/15B22F9/24B22F1/00A61K9/16A61K31/704A61K47/02A61P35/00
CPCA61K47/02A61P35/00A61K9/167A61K31/704C01B32/15C01G49/08B22F9/24C01P2002/72C01P2004/03B22F1/07
Inventor 梁春永宋吉英高炜张永光
Owner HEBEI UNIV OF TECH
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