Slow releasing micropill containing active component of indapamide and method for preparing the same

Abstract

A slowly-releasing micropill containing indapamide as its active component is composed of pill core, quick-releasing layer and slow-releasing layer. It is prepared through proportionally mixing filler, adhesive and lubricant, granulating to become (10-30)-mesh pill cores, dissolving indapamide and high-molecular adhesive in solvent, spraying it on the surface of pill cores, dissolving the retarder, pore-forming agent and plasticizer of antisticking agent in solvent, and spraying it on the surface micropill. Its advantages are high slow releasing effect within 24 hr and no sudden release.

Description

technical field [0001] The invention belongs to the technical field of drug sustained-release preparations, and more specifically relates to a sustained-release pellet containing an active ingredient of indapamide and a preparation method thereof. technical background [0002] Indapamide is a sulfonamide diuretic, which acts by inhibiting the reabsorption of water and electrolytes in the cortical dilution segment of the distal renal tubules. The possible mechanisms include the following aspects: regulation of calcium influx in vascular smooth muscle cells; Prostaglandin PGE that stimulates free vasodilation 2 and prostaglandin PGI 2 Synthesis; reduce blood vessel hypersensitivity to vasopressor amine, thereby inhibiting vasoconstriction and achieving antihypertensive effect. Common preparations currently on the domestic market include: Indapamide Tablets (Shoubishan) from Tianjin Lisheng Pharmaceutical Factory, Indapamide Tablets (Najuli) imported from France Servier Pharm...

AI Technical Summary

Problems solved by technology

However, sustained-release tablets are easily affected by operating conditions such as pressure in large-scale production, making it difficult to control the quality, and most of the sustained-release tablets are prone to burst release

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