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Preparation method of slow-release micropill with mulberry leaf extract

A technology of mulberry leaf extract and sustained-release pellets, which is applied in the field of medicine and food, can solve the problems of large fluctuations in blood drug concentration, low bioavailability, and short drug effect time, and achieve enhanced effects on the human body and simple operation Effect

Inactive Publication Date: 2011-08-31
天津市尖峰天然产物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the products of mulberry leaf extract are well recognized by consumers. These products are basically ordinary tablets and capsules. These dosage forms cause large fluctuations in blood drug concentration, short drug effect time, and low bioavailability. shortcoming

Method used

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Examples

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Effect test

Embodiment 1

[0024] A preparation method of mulberry leaf extract sustained-release pellets, comprising the steps of:

[0025] (1) Mix 100 grams of starch and 100 grams of microcrystalline cellulose evenly, add 70 grams of sucrose, use a granulator to granulate and roll pellets to the required mesh size of 20-30 mesh, and add 30 grams of talcum powder while rolling the pellets , and dried to obtain a smooth blank core.

[0026] (2) Add 300 grams of mulberry leaf extract and 200 grams of polyvinylpyrrolidone into 2L of water, and ultrasonicate for 20 minutes to make a uniform solution. On a fluidized bed, keep the temperature of the blank pellet core at 40°C, and spray the solution evenly In the outer layer of the blank pellet core, quick-release pellets are made.

[0027] (3) 120 grams of ethyl cellulose, 40 grams of carboxymethyl cellulose and 40 grams of diethyl phthalate were added to 0.5 L of water, ultrasonicated for 20 minutes to make a uniform solution, and kept on a fluidized bed ...

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Abstract

The invention discloses a preparation method of a slow-release micropill with mulberry leaf extract, which comprises the following steps: (1) proportionally and evenly mixing a filler, a binder and a lubricant to prepare a smooth spherical blank pill core of 20-30 meshes; (2) preparing the mulberry leaf extract and a high molecular material binder into a mixed solution, and coating the mixed solution at the outer layer of the blank pill core to prepare a quick-release micropill; and (3) dissolving a retarder, a hole former and a plasticizer with a coating solvent, and then, spraying at the outer layer of the quick-release micropill to prepare the slow-release micropill. The weight increment of the slow-release micropill is controlled to be 5-25%. The slow-release micropill prepared by the invention can be effectively controlled to be released in a certain period of time, the effective blood concentration can be maintained for 24 hours, and no burst-release phenomenon occurs, thereby greatly enhancing the effect of the mulberry leaf extract on a human body. The method disclosed by the invention is simple to operate and is easy to realize industrialized production.

Description

technical field [0001] The invention relates to the technical field of medicine and food, in particular to a preparation method of mulberry leaf extract sustained-release pellets. Background technique [0002] Dr. Nojiri, a Japanese scientist, has conducted research on mulberry leaves for 20 years. What works on the human body is a miraculous ingredient in mulberry leaves - DNJ. Only 1 gram of DNJ can be extracted from every 20 kilograms of mulberry leaves, which is more precious than gold. Therefore, it is also known as the "green diamond" in nature! [0003] The full name of DNJ is 1-deoxynojirimycin. It can be seen under an electron microscope that the structure of DNJ is very similar to that of glucose, except that the "oxygen" on one molecular chain of glucose is replaced with "nitrogen". It is this unique molecular structure that allows DNJ to effectively control the speed and quantity of food converted into blood sugar in the small intestine, making the rise of blood...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61K9/16A23L1/29A61P3/10A61K127/00A23L33/00
Inventor 陈国华
Owner 天津市尖峰天然产物研究开发有限公司
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