98results about How to "No burst phenomenon" patented technology

The invention relates to an explosion-proof iron runner castable which comprises the following raw materials in percentage by weight: 55-80 percent of fusion tabular corundum, 10-30 percent of silicon carbide, 1-5 percent of soft clay, 2-5 percent of pure calcium aluminate cement, 1-7 percent of submicron powder, 0.5-1.5 percent of explosion-proof agent and 0.05-0.15 percent of water reducing agent, wherein the explosion-proof agent is a mixture of aluminum powder, aluminum lactate, explosion-proof fiber and boron carbide powder with the weight ratio of 1-2:2.5-4:1-2.5:2-4. The castable of the invention has no cracks after demoulding and drying and no spalling during baking, has the safe explosion-proof temperature of 800 DEG C increased from 500 DEG C, can be subjected to construction under heat state and rapid temperature rise without spalling and can meet the operating requirements of rapid construction of middle and small size blast furnace iron runner. The castable has long service life, can improve the environment of a casting house, greatly reduces the labor intensity of the workers, improves the quality of molten iron and enhances the application safety factor of the iron runner.

The invention discloses an injectable hollow hydroxyapatite microsphere / chitosan composite drug carrier material. The material comprises the following components in percentage by weight: 0.5-2wt% of hollow hydroxyapatite, 2wt% of chitosan, 5.6wt% of beta-sodium glycerophosphate and 90.4-91.9 wt% of water. The preparation method comprises the following steps: first, loading drug in the hollow sodium hydroxyapatite microsphere; then, preparing chitosan thermo-sensitive hydrogel; finally, mixing the drug-loaded hollow hydroxyapatite microsphere and the chitosan thermo-sensitive hydrogel in a solid-liquid ratio of (0.05-0.2)g / 10ml, and stirring to obtain the injectable hollow hydroxyapatite microsphere / chitosan composite drug carrier material. The material can realize slow and controlled release of drug, gives the material injectable molding property, and realizse minimally invasive therapy to bone defect or fracture.

The invention relates to a quercetin nanoparticle and a preparation method thereof. The quercetin nanoparticle is prepared by using one or two selected from the group consisting of a nanometer precipitation process and a high pressure homogenization process. According to the invention, quercetin is used as a bulk drug, TPGS (vitamin E polyethanediol succinate) is used as a main stabilizing agent, and a mass ratio of the bulk drug to the carrier stabilizing agent is 1: 20 to 10: 1. The prepared quercetin nanoparticle has a small particle size and a high drug loading rate, and when a drug-carrier ratio is 5: 1, the average particle size of the quercetin nanoparticle is 173.21 nm and the drug-loading rate is about 80%; moreover, the prepared quercetin nanoparticle has good stability, the drug exists in crystal form in the nanoparticle, and an obvious slow release effect in vitro is obtained. The quercetin nanoparticle with a high drug loading rate and a small particle size can be prepared by using TPGS, shows obvious slow release effect in vitro, overcomes the problem of poor water-solubility and has good application prospects.

The invention discloses a preparation method of a composite pellet, which includes the working procedures of preparing materials, measuring, mulling, pressing and drying. Compared with the prior art, the preparation method is simple to be operated and has the advantages that: (1) the composite conception is broad; the pellet not only has a manganese material, but also has a reducer needed by smelting and takes coal for replacing tar and reducing the production cost; the material containing manganese not only includes the powder of a manganese ore (molybdenum concentrate, imported fine ore, slag rich in manganese, sintering fine ore and baking fine ore), but also includes manganese soot and improves the operating factor of resources; (2) the materials adopted by the composite pellet are broad in granularity; the granularity of the manganese ore (molybdenum concentrate, slag rich in manganese, sintering fine ore and baking fine ore) is between 0 and -3mm, the granularity of the coal is between 0 and -5mm, and the production technique is simplified; (3) drying is carried out under lower temperature, thus saving energy resources; and (4) a dry power sintering agent is used and the operation is simple and convenient. The composite pellet is applied to smelting manganese series iron alloys by electric furnaces and the smelting effect of the electric furnaces is good.

The present invention relates to a film transistor liquid crystal display panel, its array base plate and its production method. Said production method is characterized by that a colour light-filtering film can be adopted and integrated on a film transistor array, and on the film transistor a colour light-fitering lamina is formed as black matrix, so that it can save time and reduce cost. Besides, the edge of view area of diplay panel also can be equipped with colour light-filtering lamina so as to reduce light leakage. The edge of view area has liquid crystal injection hole, in order to increase aperture of said hole and reduce light leakage of said position an overlapped metal layer can be placed in colour light-filtering region block. Besides, said invention also puts forward some other attention problems so as to raise the quality of display panel.

A nanoparticle with hydrophobic core and hydrophilic surface used for medicine, food, or cosmetics features that it contains hydrophobic polymer block and hydrophilic polymer block. Its preparing process includes such steps as generating the free amino of chitosan under action of trigger, and combining with hydrophilic unsaturated monomer and alkyl acrylata (or methylacrylate) to obtain triblock copolymer.

The invention discloses a method for preparing a graphene oxide film and a graphene oxide film product. The method comprises the following steps: mixing graphene oxide dispersion liquid and amino terminal-hyperbranched or dendritic polymer, carrying out suction filtering to prepare the graphene oxide film. The invention further discloses a method for preparing the graphene oxide film for sustained release of drug and a graphene oxide film product, and the method comprises the steps of mixing the graphene oxide dispersion liquid and the amino terminal-hyperbranched or dendritic polymer, adding a medicine with an aromatic nucleus into the mixed solution, and finally carrying out suction filtering. According to the method, the graphene oxide is crosslinked by means of the amino terminal-hyperbranched or dendritic polymer to form a flat lamellar film, so that the film has a relatively high film stability in an aqueous environment, the sustained-release controlled-release performance of drug can be improved, and the drug loading capacity of the film can be improved; and the graphene oxide film for sustained-release of drug is slowly released in a damp or aqueous environment and has the advantages of long maintaining duration and remarkable antibacterial effect.

The invention provides a switching module of a USB electrical connector. An insulating seat body on a base and a tongue portion of the USB electrical connector is used for a plurality of terminals of a terminal group to respectively penetrate terminal slots of the base and used for linkage faces of a plurality of signal terminals to extend to the surface of the tongue portion, welding portions of a plurality of terminals and welding sides of a plurality of signal terminals respectively extends out of the base, the insulating seat body is covered by a shielding housing, the shielding housing is provided with an assembly portion on one side of an accommodating space, the assembly portion is used for a shielding cover body of a switching device to be movably assembled, an insulating body and a plurality of switching terminals are arranged in the shielding cover body, and the abutting-against sides of the switching terminals can electrically abut against the linkage faces of a plurality of signal terminals to enable the switching device to be movably flipped on the shielding housing. The switching module can be used for switching application of different specifications of USB electrical connectors.

The invention discloses a long-acting sustained-release wound dressing containing levofloxacin sustained-release microspheres. According to the preparation method of the wound dressing, levofloxacin sustained-release microspheres with grain diameter between 10 and 20mu m are fixed in a composite medical non-woven fabric which mainly comprises chitosan fiber, alginate fiber, viscose fiber, and hydrophobic ethylene propylene fiber; and the long-acting sustained-release wound dressing is prepared by taking the levofloxacin sustained-release microspheres as a medicinal component. In a use process, the medicament quickly release levofloxacin after contacting the blood, tissues and surrounding skin of the wound, and can continuously release levofloxacin for a long time, and the effective release of levofloxacin accumulatively reaches 168h. The long-acting sustained-release wound dressing is applied to treatment of bacterium infection of burnt and scalded skin, and the microsphere state medicament can remarkably improve the bioavailability of effective components of the medicament; and the long-acting sustained-release wound dressing has excellent moisture penetrability, hygroscopicity, mechanical tensile property and biocompatibility, the frequency of dressing change can be reduced, and the curative effect and administration safety cam be enhanced.

The invention discloses a fiber-reinforced phenolic resin-based composite material and a preparation method thereof. The preparation method comprises the following steps: firstly preparing phenolic resin modified by nano-clay, preparing an acid curing agent, adding the acid curing agent into the phenolic resin modified by the nano-clay and uniformly stirring to obtain resin liquid; and selecting a fiber reinforcing material, molding in a mold by a molding process, and then curing at low temperature to obtain the fiber-reinforced phenolic resin-based composite material. The fiber-reinforced phenolic resin-based composite material prepared by the preparation method disclosed by the invention is prepared by curing the phenolic resin at normal pressure and low temperature of 25 DEG C-80 DEG C, and the material is stable to a fire reaction and has no phenomena of surface bubbling, deformation, delamination and burst when meeting high heat. The material has excellent F / S / T performance, achieves 1a-grade level of a BS6853 test and further has excellent performances of high mechanical strength, good fatigue resistance, heat resistance, resistance to strong acid corrosion and the like.

An environment protection type emulsoid paint without VOC is prepared from water, sodium polyacrylate "5040", hydroxyethyl cellulose "250HBR", mineral oil modified silicone BYK-003, titanium white powder, filming agent and assistant. Its advantages are high hardness and adhesion, high resistance to dirt, zero VOC and no poison and harm.

The invention provides high-bulk coated white kraft paper which comprises base paper and coating layers formed on two surfaces of the base paper. Paper pulp for preparing the base paper comprises sulphate softwood pulp which has the freeness of 400 to 450 ml after being pulped and the bulk of 1.25 to 1.35 cm<3> / g, bleached sulphate hardwood pulp which has the freeness of 380 to 430 ml after being pulped and the bulk of 1.25 to 1.35 cm<3> / g, bleached chemithermomechanical pulp which has the freeness of 300 to 350 ml after being pulped and the bulk of 2.8 to 3.2 cm<3> / g, and filler, a paper strength agent and a sizing agent. A coating for preparing the coating layers comprises carclazyte, pigment and an adhesive. The coated white kraft paper provided by the invention is high in bulk, good in stiffness and good in smoothness; during printing, the phenomenon of paper clamping can be avoided; after being printed, the high-bulk coated white kraft paper can be directly processed and made into a bag, so that the printing processing efficiency can be improved, and the printing cost can be reduced.

The invention relates to a potassium chloride sustained-release pellet and a preparation method and application thereof. The potassium chloride sustained-release pellet provided by the invention comprises a pellet core, a potassium chloride main drug layer, an isolated layer, a sustained-release coating layer and a colored coating layer. According to the potassium chloride sustained-release pelletprepared in the invention, the release amount within 1 hour is smaller than or equal to 25%, the release amount within 4 hours is smaller than or equal to 70%, and the release amount of the potassiumchloride sustained-release pellet within 8 hours is smaller than or equal to 85%. By using the sustained-release coating material, the drug is released stably by accurately controlling the sustained-release speed of potassium chloride inside the potassium chloride sustained-release pellet, an expected blood concentration is obtained, relatively long action time can be maintained, the phenomenon of sudden release does not exist, and adverse reactions such as stimulation for gastric mucosa can be avoided.

The present invention relates to the field of medicine preparation, in the concrete, it relates to a show-released fibre preparation of water-soluble anti-cancer medicine for body implantation and its preparation method. It is characterized by that the fibre carrier is oil-soluble biological degradable material. and the medicine is water-soluble anticancer medicine, its medicine content is up to 15-50%.

The invention provides a preparation method of clove flavor cigar with an auditory effect. The preparation method concretely comprises the following steps of picking clove according to requirements; performing cleaning and dust removal on the picked dry clove buds; performing drying through drying equipment; taking out the buds for use after the water content is lower than 5 percent; putting 5 to6 processed clove buds into the center position of a single cigar core leaf; sequentially distributing the clove buds into a line to prepare a cigar core; then, taking one leaf roll for winding the cigar core; performing fixing and shaping; then, putting the materials into a wood cigar mold for 30 to 45 minutes; finally, taking one piece of a binder leaf for well covering a cigarette bundle; usingplant glue for bonding and winding the cigar; next, putting the cigar into a refrigerator; putting the refrigerator into a constant-temperature constant-humidity balance room; controlling the temperature to be 18 to 20 DEG C and the humidity to be 65 to 75 percent; performing placement for 25 to 35 days. The prepared cigar has the slight clove flavor; during the smoking, the uniform slight clacking sound is generated at a frequency of once per 2 to 3 seconds; the sound volume is proper; the auditory effect is added for the cigar smoking.

The invention belongs to the technical field of solid waste environmental protection treatment and building material production, the invention discloses a preparation method of a ceramic tile from waste fly ash, the preparation method comprises: the incineration waste fly ash is mixed with a stabilizer and aged to obtain stabilized fly ash; a composite powder material is prepared from, by weight,25-45% of the stabilized fly ash , 22-55% of a ridge material and 15%-48% of a correcting material by uniformly mixing; the composite powder material is subjected to dry-press molding and natural drying to obtain a to-be-sintered body; and the to-be-sintered body is sintered at a high temperature, and then cooled to obtain the ceramic tile, wherein the stabilizer is roasted hydrotalcite. The method provided by the invention realizes the treatment of fly ash, and harmless and resource utilization of fly ash disposal and utilization are taken into consideration; the dependence on natural resources is reduced from the designed angle of the material, and the fly ash and other solid wastes can be treated and utilized cooperatively, so that harmless and resource synchronization of the bulk solidwaste can be realized.

The invention belongs to the technical field of wine brewing and discloses distiller yeast as well as a preparation method thereof and a method for producing white spirit by virtue of the distiller yeast. The distiller yeast comprises the following components in parts by weight: 100 parts of rice, 20-25 parts of soybeans, 1.5-3.5 parts of seed yeast, 5-12 parts of folium isatidis, 5.8-6.7 parts of water, 25-35 parts of chaff and 1.5-3.5 parts of bran. The preparation method of distiller yeast comprises the following steps: steaming rice and soybeans, grinding the seed yeast into coarse powder, mixing coarse powder, chaff and bran, adding water and blending, pressing the mixture into yeast preform, hanging yeast and culturing for 6-10 days to obtain the distiller yeast. The method for producing white spirit by virtue of the distiller yeast comprises the following steps: preparing ingredients at a weight ratio of rice to distiller yeast being 1: (0.15-0.25), adding water which is 2-2.5 times of total weight of the ingredients, uniformly mixing and fermenting for 15-20 days; and distilling to obtain wine, storing for 6-15 days, soaking with fat pork for 20-30 days, taking out liquor, storing for over a month and blending to obtain the white spirit.

The invention discloses a vascular occlusive agent, application thereof and a preparation method. The vascular occlusive agent is a multivesicular liposome formed by accumulating non-concentric cells, the cells are connected with one another through lipid membranes and are externally coated by lipid membranes with proper surface areas, the multivesicular liposome can be scattered into single liposomes at a vascular embolization position, the particle size of the multivesicular liposome ranges from 5 micrometers and 100 micrometers, and a contrast agent, an antitumor drug or combination of the contrast agent and the antitumor drug can be wrapped in the multivesicular liposome. The occlusive agent wrapping the contrast agent and the antitumor drug simultaneously has the functions of embolization, development and tumor resistance and can be used for realizing target vascular embolization in interventional therapy, the developable multivesicular liposome containing the antitumor drug can be directionally deposited in a tumor blood supply vessel by the aid of transcatheter arterial chemoembolization, peripheral vascular embolization is realized as the cells are gradually disintegrated, and CT (computerized tomography) development at the embolization position can be realized.

The invention relates to the field of medicines, and particularly relates to a liraglutide multivesicular liposome and a preparation method and an application thereof. The liraglutide multivesicular liposome provided by the invention comprises liraglutide, a membrane material, an osmotic pressure regulator and a stabilizer. The liraglutide multivesicular liposome prepared by the invention has goodstability, high drug encapsulation rate, large drug loading capacity, slow and steady drug release rate and no burst release phenomenon, significantly improves the bioavailability of the drug, thereby improving the curative effect, reduces dose-related side effects of the drug and medication cost and has a higher application value. Experiments shows that the liposome provided by the present invention can continuously release the drug in vitro for about 432 hours, and provide a stable blood concentration in vivo, significantly prolongs in-vivo retention time compared to other injections, showsobvious pharmacokinetic characteristics of a sustained release preparation, can provide a normal steady blood glucose level, plays hypoglycemic effect for 312 hours, and has the relative bioavailability of 661% to injections.

The invention relates to a novel emulsion paint which comprises the following components in percentage by weight: 8.5% of ultramarine, 0.2% of cellulose, 0.07% of humidizer, 0.6% of dispersing agent, 4.2% of titanium white, 17.7% of silicon dioxide superfine powder, 5.7% of kaolin, 7.1% of calcium carbonate light, 7.1% of sierozem, 2.8% of talcum powder, 14.2% of poval, 14.2% of high polymer emulsion and 17.63% of water. The novel emulsion paint has the advantages of ageing resistance, high strength, wet rub resistance, flat and smooth surface and the like, and has less possibility of shedding; after the novel emulsion paint is used for a long term, no splitting phenomenon occurs; and due to high density, the novel emulsion paint has better stain resistance.

The invention discloses a special electrode component and an electric arc tube of a ceramic metal halide lamp and a manufacturing method of the electric arc tube, the special electrode component comprises a metal ceramic rod, one end of the metal ceramic rod is connected with a tungsten electrode rod, the other end is connected with a niobium rod utilized to feed, besides, the metal ceramic rod, the tungsten electrode rod and the niobium rod are in an identical axial line, and the end portion of the tungsten electrode rod is a tungsten ring. At least one special electrode component is used in the electric arc tube, and the electric arc tube is utilized to manufacture the ceramic metal halide lamp, when in seal production, glass solder is only required to cover a portion or all parts of the metal ceramic rod of the special electrode component. The invention utilizes novel materials in the special electrode component, is greatly simple and convenient in technique for sealing tail tubes of a ceramic discharge chamber, is strong in operation reliability, reduces crack problems in seal positions of the ceramic tail tubes, and prolongs the service life of finished lamps.

The invention discloses a tempered glass processing technology. The processing technology mainly comprises the following steps of glass surface cleaning, glass preheating, silicon dioxide powder spraying on the glass surface, high power heating on glass, cooling liquid spraying for cooling and natural cooling. According to the tempered glass processing technology, the production technology is simple, the made tempered glass has high surface stress and toughness, and the yield is increased; meanwhile, cooling is conducted by adopting a cooling liquid, the cooling speed can be increased, and the tempered glass cannot burst.

The invention provides an oral dry suspension composition capable of realizing controllable drug-release speed through modification combination design and a preparation method thereof. The oral dry suspension composition comprises a pharmaceutically acceptable excipient and a modified medicine-ion exchange resin compound. The medicine-ion exchange resin compound comprises a compound formed by combining a pharmaceutically acceptable active medicine and pharmaceutically acceptable ion exchange resin, and a polymer system which can be dissolved in water for modifying the compound. The invention provides a medical resin compound preparation and modification method as well as a preparation method of a dry suspension containing the compound; better taste masking effect is realized, the drug release speed is controllable according to different treatment requirements, and the dry suspension has the characteristics of small particles and no gritty mouthfeel, and is especially suitable for a children preparation.

The invention relates to a water-insoluble drug, namely, tacrolimus sustained-release tablets. The tacrolimus sustained-release tablets take a lipid material, a water-soluble material, a stabilizer and the like as a carrier, and are prepared by adopting a melting method to prepare a solid dispersion which is stable in properties and is capable of obviously improving the dissolution rate of tacrolimus, blending the prepared solid dispersion with a sustained-release material, a diluent and other pharmaceutical necessities, and tabletting the mixture. The tacrolimus sustained-release tablets have the unique advantages that (1) the sustained-release tablets are simple in formulation and technology, and can be formed by directly tabletting powder without adding auxiliary materials such as a lubricating agent and a binding agent; (2) the low-melting-point lipid material is used, the medicine can be directly dissolved in the molten lipid material and is then cooled and cured, and a volatile organic solvent does not need to be treated, so that the production safety is greatly improved, and the environmental pollution is reduced; (3) the quaternary solid dispersion formed by the medicine, the lipid material, the water-soluble material and the stabilizer is good in stability, so that the dissolution rate of the tacrolimus sustained-release tablets does not change significantly after the tacrolimus sustained-release tablets are placed for a period of time; (4) the tacrolimus sustained-release tablets can reduce the times of administration, thus reducing the fluctuation of plasma concentration.

The invention discloses high-flexibility water varnish suitable for UV curable offset printing. According to key points of the technical scheme, the water varnish is composed of the following components by weight percent: 10-20% of pure acrylic emulsion, 5-15% of acrylic-modified aqueous polyurethane emulsion, 35-55% of a self-crosslinked acrylic dispersing agent, 10-25% of water, 10-25% of an alcohol solvent and 0.1-5% of waterborne additives. The invention provides the high-flexibility water varnish suitable for UV curable offset printing. The invention further provides a method for preparing the high-flexibility water varnish suitable for UV curable offset printing.

The invention relates to a method for preparing pH-sensitive cellulose ether and ester medicament-carrying electrospinning fibers and belongs to the technical field of polymer chemistry. The method comprises: firstly, dissolving a medicament and pH-sensitive cellulose ethers and esters in a proper solvent in a certain proportion to prepare homogeneous electrospinning solution at a certain concentration; and secondly, spinning pH-sensitive cellulose ether and ester medicament-carrying nano fibers with a diameter of 80 to 1,500 nanometers, smooth surfaces and uniform thickness with the electrospinning solution under the action of an electrostatic field at a certain spinning temperature and a certain voltage by using an electrospinning technique and adjusting extrusion speed and receiving distance. The obtained fibers have the advantages of ultra-small diameter, extremely large specific surface and the like and therefore have promising application prospects in many fields. Medicament-carrying fiber nonwoven fabrics can be manufactured by electrospinning spinning solution with the dissolved medicament. And due to the pH-sensitive characteristic of the cellulose ethers and esters, the targeted and sustained release of the medicament in the intestines and stomach can be realized.

The invention belongs to the technical field of pharmaceutical preparation, and specifically relates to a sustained-release microsphere preparation of a glucagon-like peptide-1 analogue and a preparation method of the microsphere preparation. The weight components of the microsphere preparation comprise 10-25 parts of glucagon-like peptide-1 analogue, 1-5 parts of beta-cyclodextrin derivative, 100parts of PLGA and polycaprolactone mixture, and 15-25 parts of PEG, wherein the mass ratio of PLGA to polycaprolactone is 1:(0.2-1). The drug-loaded microspheres encapsulating the glucagon-like peptide-1 analogue are prepared by using a compound emulsion-emulsion solvent volatilization method. The microspheres prepared by the invention have a long drug-release period, good drug stability, high safety and broad application prospects.

The invention provides a preparation process for an anti-explosion castable. The anti-explosion castable comprises the following raw materials in parts by mass: 60 parts of special bauxite aggregates, 17 parts of bauxite clinker powder, 8 parts of fused alumina powder, 4 parts of kyanite, 2 parts of anti-explosion fibers, 9 parts of silica powder, 10 parts of calcium aluminate cement and 0.5 part of an additive, wherein the special bauxite aggregates include more than 20% of special bauxite aggregates with the grain sizes of 5-3 mm, more than 15% of special bauxite aggregates with the grain sizes of 3-1 mm and more than 15% of special bauxite aggregates with the grain sizes of 1-0 mm; the bauxite clinker powder is 200-mesh and the fused alumina powder has the grain size of 3-5 microns. The preparation process comprises the following steps: grinding the raw materials, wherein the special bauxite aggregates are ground to have the grain sizes of 5-3 mm, 3-1 mm and 1-0 mm respectively, and the bauxite clinker is ground into 200-mesh powder; starting a stirrer for stirring for 8-10 minutes; detecting and packaging. According to the preparation process provided by the invention, the anti-explosion castable is high in compactness, good in fire resistance and excellent in slag resistance.

The invention belongs to the technical field of medicine preparation, and discloses a preparation method of a ziconotide injection hypodermic implant as well as the ziconotide injection hypodermic implant prepared by the method. The implant prepared by the method is dissolved by sterile water for injection before use and is then injected to human subcutaneous tissues. The implant prepared by the method is a novel sustained-release preparation which can be subcutaneously injected in form of a liquid. Under the effect of body temperature, the liquor becomes a gel which is slowly released in vivo, so that a long-acting effect of treating and relieving pains is realized.

The invention discloses a sustained release tablet containing an effective component hydrochloric acid vilazodone. The sustained release tablet is prepared from the effective component hydrochloric acid vilazodone and sustained release materials; the weight ratio of effective component hydrochloric acid vilazodone to sustained release materials is (1: 0.2)-(1: 20), preferably (1:0.5)-(1:10); and the sustained release material used by the sustained release tablet is one or a combination of several of guar gum, xanthan gum, acrylic resin and cellulose. The hydrochloric acid vilazodone has the characteristics of lasting functions, low toxic and side effects and less medicine-taking times; the release degree in vitro of the sustained release tablet is 8-24 hours; the blood medicine concentration is stable; the occurrence ratio of poor reaction is reduced; the curative effect of the medicines is improved; and the pain of patients is relieved.