Nano granules possessing hydrophobic core and hydrophilic surface, preparation method and application

A hydrophilic surface, nanoparticle technology, applied in the fields of botanical equipment and methods, applications, chemical instruments and methods, etc., can solve the problem of sudden release and poor stability, low amount of active ingredients loaded in nanoparticles, hydrophilic active ingredient ability Low problems, to achieve the effect of not easy coagulation and precipitation, avoiding easy flocculation and precipitation, and easy synthesis route

Inactive Publication Date: 2006-04-19
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Before the 1990s, the materials of nanoparticles were mostly acrylic acid derivatives, and most of these materials were hydrophobic, and the ability to carry hydrophilic active ingredients was low.
Existing nanoparticles have disadvantages such as low loading of active ingredients, burst release and poor stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Add 0.75 grams of chitosan to 70ml of 1% acetic acid, heat to 60°C, stir until the chitosan is completely dissolved, add 1.5 grams of methyl methacrylate and 0.0175 grams of ammonium persulfate, react for 2 hours, and dialyze for 48 hours , lyophilized into powder, dispersed in water to form diblock nanoparticles (CM nanoparticles), the particle size is 152.6nm.

Embodiment 2

[0054] Add 0.75 g of chitosan to 70 ml of 1% acetic acid, heat to 65 ° C, stir until the chitosan is completely dissolved, add 1.5 g of n-butyl methacrylate and 0.02 g of ammonium persulfate, react for 3 hours, and dialyze for 72 Hours, freeze-dried into powder, dispersed in water to form diblock nanoparticles with a particle size of 187.4nm.

Embodiment 3

[0056] Add 1 gram of chitosan to 95ml of 1% acetic acid, heat to 70°C, stir until the chitosan is completely dissolved, blow in nitrogen, add 0.1 gram of potassium persulfate, and add 1 gram of quaternary ammonium methacrylate after 10 minutes Salt, add 1.5 grams of methyl methacrylate after 30 minutes, react for 18 hours, dialyze for 96 hours, freeze-dry to powder, disperse in water to form triblock nanoparticles (CTM nanoparticles), particle size is 169.2nm.

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Abstract

A nanoparticle with hydrophobic core and hydrophilic surface used for medicine, food, or cosmetics features that it contains hydrophobic polymer block and hydrophilic polymer block. Its preparing process includes such steps as generating the free amino of chitosan under action of trigger, and combining with hydrophilic unsaturated monomer and alkyl acrylata (or methylacrylate) to obtain triblock copolymer.

Description

technical field [0001] The invention belongs to the technical field of amphiphilic nanometer materials, and specifically relates to a block copolymer nanoparticle with a hydrophobic core and a hydrophilic surface, a preparation method and application thereof. Background technique [0002] Modern nanotechnology and nanoscience refer to the science of studying the physical and chemical properties and functions of substances with a particle size of 1-100nm. It can assemble and create substances with specific functions by directly manipulating individual atoms and molecules. Nanoparticles are made of high molecular substances, and active ingredients can be dissolved, adsorbed or encapsulated in the material. Generally, nanoparticles have the functions of slow release, targeting and protection of active ingredients, which can improve efficacy and reduce side effects. Nanoparticles are not easy to block blood vessels, and can pass through the endothelial wall to reach the target ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F285/00C07K17/08A01N25/10A61K8/90A61Q1/00
Inventor 印春华钱锋崔福英唐翠
Owner FUDAN UNIV
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