Nano granules possessing hydrophobic core and hydrophilic surface, preparation method and application

Abstract

A nanoparticle with hydrophobic core and hydrophilic surface used for medicine, food, or cosmetics features that it contains hydrophobic polymer block and hydrophilic polymer block. Its preparing process includes such steps as generating the free amino of chitosan under action of trigger, and combining with hydrophilic unsaturated monomer and alkyl acrylata (or methylacrylate) to obtain triblock copolymer.

Description

technical field [0001] The invention belongs to the technical field of amphiphilic nanometer materials, and specifically relates to a block copolymer nanoparticle with a hydrophobic core and a hydrophilic surface, a preparation method and application thereof. Background technique [0002] Modern nanotechnology and nanoscience refer to the science of studying the physical and chemical properties and functions of substances with a particle size of 1-100nm. It can assemble and create substances with specific functions by directly manipulating individual atoms and molecules. Nanoparticles are made of high molecular substances, and active ingredients can be dissolved, adsorbed or encapsulated in the material. Generally, nanoparticles have the functions of slow release, targeting and protection of active ingredients, which can improve efficacy and reduce side effects. Nanoparticles are not easy to block blood vessels, and can pass through the endothelial wall to reach the target ...

AI Technical Summary

Problems solved by technology

[0003] Before the 1990s, the materials of nanoparticles were mostly acrylic acid derivatives, and most of these materials were hydrophobic, and the ability to carry hydrophilic active ingredients was low.

Existing nanoparticles have disadvantages such as low loading of active ingredients, burst release and poor stability