Nano granules possessing hydrophobic core and hydrophilic surface, preparation method and application

A hydrophilic surface, nanoparticle technology, applied in the directions of botanical equipment and methods, applications, chemical instruments and methods, etc., can solve the problem of low hydrophilic active ingredient capability, poor burst release and stability, and nanoparticle-loaded active ingredient amount. Low problems, to avoid easy flocculation and precipitation, not easy to coagulate and precipitate, and easy synthesis route

Inactive Publication Date: 2009-06-24
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Before the 1990s, the materials of nanoparticles were mostly acrylic acid derivatives, and most of these materials were hydrophobic, and the ability to carry hydrophilic active ingredients was low.
Existing nanoparticles have disadvantages such as low loading of active ingredients, burst release and poor stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Add 0.75 grams of chitosan to 70ml of 1% acetic acid, heat to 60°C, stir until the chitosan is completely dissolved, add 1.5 grams of methyl methacrylate and 0.0175 grams of ammonium persulfate, react for 2 hours, and dialyze for 48 hours , lyophilized into powder, dispersed in water to form diblock nanoparticles (CM nanoparticles), the particle size is 152.6nm.

Embodiment 2

[0054] Add 0.75 grams of chitosan to 70ml of 1% acetic acid, heat to 65°C, stir until the chitosan is completely dissolved, add 1.5 grams of n-butyl methacrylate and 0.02 grams of ammonium persulfate, react for 3 hours, and dialyze for 72 hours , lyophilized into powder, dispersed in water to form diblock nanoparticles with a particle size of 187.4nm.

Embodiment 3

[0056] Add 1 gram of chitosan to 95ml of 1% acetic acid, heat to 70°C, stir until the chitosan is completely dissolved, blow in nitrogen, add 0.1 gram of potassium persulfate, and add 1 gram of quaternary ammonium methacrylate after 10 minutes Salt, add 1.5 grams of methyl methacrylate after 30 minutes, react for 18 hours, dialyze for 96 hours, freeze-dry to powder, disperse in water to form triblock nanoparticles (CTM nanoparticles), particle size is 169.2nm.

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PUM

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Abstract

The invention belongs to the technical field of amphiphilic nanometer materials, in particular to a nanoparticle with a hydrophobic core and a hydrophilic surface, a preparation method and application thereof. The nanoparticles of the present invention contain a hydrophobic polymer block of polyalkyl acrylate or polyalkyl methacrylate and a hydrophilic unsaturated monomer or a polymer modified by the hydrophilic unsaturated monomer. Hydrophilic polymer block of chitosan. It is prepared according to the following steps: under the action of an initiator, the amino group of chitosan is radicalized, and combined with a hydrophilic unsaturated monomer and an alkyl acrylate or an alkyl methacrylate to obtain an amphoteric tri-block copolymer . It can be used in the production of medicines, nutrition and cosmetics. Compared with the prior art, it has the characteristics of good stability and high loading of active ingredients.

Description

technical field [0001] The invention belongs to the technical field of amphiphilic nanometer materials, and specifically relates to a block copolymer nanoparticle with a hydrophobic core and a hydrophilic surface, a preparation method and application thereof. Background technique [0002] Modern nanotechnology and nanoscience refer to the science of studying the physical and chemical properties and functions of substances with a particle size of 1-100nm. It can assemble and create substances with specific functions by directly manipulating individual atoms and molecules. Nanoparticles are made of high molecular substances, and active ingredients can be dissolved, adsorbed or encapsulated in the material. Generally, nanoparticles have the functions of slow release, targeting and protection of active ingredients, which can improve efficacy and reduce side effects. Nanoparticles are not easy to block blood vessels, and can pass through the endothelial wall to reach the target ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F285/00C07K17/08A01N25/10A61K8/90A61Q1/00
Inventor 印春华钱锋崔福英唐翠
Owner FUDAN UNIV
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