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Method for preparing pH-sensitive cellulose ether and ester medicament-carrying electrospinning fibers

A technology of mixed ether ester and electrospinning, applied in the field of polymer chemistry, to achieve the effect of large specific surface area, simple operation process and small diameter

Inactive Publication Date: 2010-06-09
BEIJING INSTITUTE OF TECHNOLOGYGY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a raw material that can replace petroleum products, people have been actively studying the application of cellulose and its derivatives in various aspects, but there are few studies on the preparation of ultrafine fibers by electrospinning.

Method used

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  • Method for preparing pH-sensitive cellulose ether and ester medicament-carrying electrospinning fibers
  • Method for preparing pH-sensitive cellulose ether and ester medicament-carrying electrospinning fibers
  • Method for preparing pH-sensitive cellulose ether and ester medicament-carrying electrospinning fibers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) Prepare the solution

[0040] At room temperature, dissolve HPMCP and drug tetracycline in a mixed solvent composed of absolute ethanol / dichloromethane (1:1, v / v), and prepare concentrations of 10% to 18% respectively in 50mL iodine measuring bottles. % electrospinning solutions are about 15 mL each, wherein HPMCP:tetracycline=20:1 (mass ratio).

[0041] 2) Electrospinning

[0042] refer to figure 1 , at room temperature, the spinning solution was injected into a 20mL glass syringe, and the metal needle at the front end of the syringe was connected to a high-voltage power supply. The spinning solution was extruded at a rate of 2 mL / h through a syringe pump with set parameters. After turning on the high-voltage power supply and setting the voltage at 15kv, under the action of the electrostatic field force, the polymer solution flow is continuously stretched while flying to the grounded aluminum foil receiving plate, and at the same time the solvent volatilizes to ...

Embodiment 2

[0047] 1) Prepare the solution

[0048] At room temperature, dissolve HPMCAP and drug tetracycline in a mixed solvent composed of absolute ethanol / dichloromethane (1:1, v / v), and prepare a concentration of 9% to 15% in a 50mL iodine bottle. Each of the electrospinning solutions is about 15 mL, wherein HPMCAP:tetracycline=20:1 (mass ratio).

[0049] 2) Electrospinning

[0050] refer to figure 1 , at room temperature, the spinning solution was injected into a 20mL glass syringe, and the metal needle at the front end of the syringe was connected to a high-voltage power supply. The spinning solution was extruded at a rate of 2 mL / h through a syringe pump with set parameters. After turning on the high-voltage power supply and setting the voltage at 15kv, under the action of the electrostatic field force, the polymer solution flow is continuously stretched while flying to the grounded aluminum foil receiving plate, and at the same time the solvent volatilizes to finally obtain u...

Embodiment 3

[0054] 1) Prepare the solution

[0055] At room temperature, HPMCT and the drug tetracycline were dissolved in a mixed solvent composed of anhydrous methanol / dichloromethane (1:5, v / v), and a series of concentrations of electrospinning were prepared in 50 mL iodine flasks. Each solution is about 15 mL, wherein HPMCAT:tetracycline=20:1 (mass ratio).

[0056] 2) Electrospinning

[0057] refer to figure 1 , at room temperature, the spinning solution was injected into a 20mL glass syringe, and the metal needle at the front end of the syringe was connected to a high-voltage power supply. The spinning solution was extruded at a rate of 2 mL / h through a syringe pump with set parameters. After turning on the high-voltage power supply and setting the voltage at 15kv, under the action of the electrostatic field force, the polymer solution flow is continuously stretched while flying to the grounded aluminum foil receiving plate, and at the same time the solvent volatilizes to finally...

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Abstract

The invention relates to a method for preparing pH-sensitive cellulose ether and ester medicament-carrying electrospinning fibers and belongs to the technical field of polymer chemistry. The method comprises: firstly, dissolving a medicament and pH-sensitive cellulose ethers and esters in a proper solvent in a certain proportion to prepare homogeneous electrospinning solution at a certain concentration; and secondly, spinning pH-sensitive cellulose ether and ester medicament-carrying nano fibers with a diameter of 80 to 1,500 nanometers, smooth surfaces and uniform thickness with the electrospinning solution under the action of an electrostatic field at a certain spinning temperature and a certain voltage by using an electrospinning technique and adjusting extrusion speed and receiving distance. The obtained fibers have the advantages of ultra-small diameter, extremely large specific surface and the like and therefore have promising application prospects in many fields. Medicament-carrying fiber nonwoven fabrics can be manufactured by electrospinning spinning solution with the dissolved medicament. And due to the pH-sensitive characteristic of the cellulose ethers and esters, the targeted and sustained release of the medicament in the intestines and stomach can be realized.

Description

technical field [0001] The invention relates to a preparation method of a pH-sensitive cellulose mixed ether ester drug-loaded electrospun fiber, belonging to the technical field of polymer chemistry. Background technique [0002] In recent years, electrospinning has attracted more and more attention. For electrospinning, its process conditions are the basis of the entire electrospinning research, and it is also one of the most researched contents at present. In the electrospinning process, the process variables that affect the properties of polymer fibers mainly include two aspects: polymer fluid properties and spinning process parameters. The characteristics of polymer fluids are mainly the relative molecular weight of polymers, the structure of chain segments, and the viscosity, electrical conductivity, surface tension and other characteristic parameters of polymer fluids (solutions or melts). The spinning process parameters mainly include the electrostatic field streng...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01D1/02D01D5/00D01F2/24A61K9/00A61K47/38
Inventor 邵自强毕新德吴培王霞王飞俊王文俊杨丙刚毕英德
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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