Sustained release tablet containing effective component hydrochloric acid vilazodone
A technology of vilazodone hydrochloride and active ingredients, which is applied in the field of medicine, can solve the problems of poor compliance, large fluctuations in blood drug concentration, and large toxic and side effects in patients with severe depression, so as to reduce the incidence of adverse reactions and reduce medication The effect of frequency and convenience
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Embodiment 1
[0031] Embodiment 1 (1000 pieces amount)
[0032]
[0033] Preparation Process:
[0034] Pass the main ingredient and auxiliary materials through an 80-mesh sieve respectively, and set aside. Weigh the prescription amount of excipients (except hydroxypropyl cellulose 4000cp and magnesium stearate, micropowder silica gel) and mix well with the main ingredient, add soft materials made of binders, granulate with a 20-mesh sieve, dry at 55°C for 18 Mesh sieve for whole grains. Finally, magnesium stearate, micropowder silica gel and hydroxypropyl cellulose are added and mixed evenly, and the intermediate is determined and then compressed into tablets.
Embodiment 2
[0035] Embodiment 2 (quantity of 1000 pieces)
[0036]
[0037] Preparation Process:
[0038] Pass the main ingredient and auxiliary materials through a 60-mesh sieve respectively, and set aside. Weigh the main drug in the prescribed amount and mix it well with the auxiliary materials guar gum, hypromellose, lactose, talcum powder and magnesium stearate in turn, and directly compress the tablet after measuring the intermediate.
Embodiment 3
[0039] Embodiment 3 (quantity of 1000 pieces)
[0040]
[0041] Preparation Process:
[0042] Pass the main ingredient and auxiliary materials through an 80-mesh sieve respectively, and set aside. First weigh the prescription amount of excipients (except hydroxypropyl cellulose 4000cp and talcum powder, micro-powder silica gel) and mix well with the main ingredient, add a soft material made of binder, granulate with a 20-mesh sieve, dry at 55°C, and granulate with a 18-mesh sieve whole grain. Finally, talcum powder, micropowder silica gel and hydroxypropyl cellulose are added and mixed evenly, and the intermediate is determined and then pressed into tablets.
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