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Method for preparing graphene oxide film for sustained release of and graphene oxide film product

A graphene film and graphene technology, which is applied in the field of medicine and chemical industry, can solve the problems of unstable mechanical properties of graphene oxide film, falling off of graphene oxide particles, and speed up the release of loaded drugs, so as to increase drug binding sites, Increase drug load, improve the effect of drug sustained release and controlled release performance

Inactive Publication Date: 2014-12-10
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the graphene oxide film has good mechanical strength and mechanical stability under dry conditions, when it is placed in a humid or water environment, the mechanical properties of the graphene oxide film will become unstable, and the graphene oxide particles are easy to decompose from the film. The release rate of loaded drugs is accelerated, which limits the application of pure graphene oxide films in the field of drug delivery.

Method used

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  • Method for preparing graphene oxide film for sustained release of and graphene oxide film product
  • Method for preparing graphene oxide film for sustained release of and graphene oxide film product
  • Method for preparing graphene oxide film for sustained release of and graphene oxide film product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of graphene oxide film

[0033] Add 10 mg of graphene oxide (purchased from Nanjing Xianfeng Nano Co., Ltd., product number XF002) into 100 mL of deionized water for 2.5 hours to obtain a graphene oxide dispersion; add 1 mL of 10 mg / mL to the graphene oxide dispersion Hyperbranched polyethyleneimine (purchased from SIGMA-ALDRICH company, product number 408727) aqueous solution, vigorously stirred at 180r / min for 30min, sonicated at 200kHz for 15min to obtain a homogeneous mixture, and filtered on CA microfiltration membrane , The suction filtration time is 24h, the graphene oxide film (such as figure 1 ).

Embodiment 2

[0034] Example 2 Preparation of a graphene oxide film containing ciprofloxacin for sustained drug release using dendritic polyethyleneimine as a crosslinking agent

[0035] Add 10 mg of graphene oxide (purchased from Nanjing Xianfeng Nano Co., Ltd., product number XF002) into 100 mL of deionized water and sonicate for 2.5 hours to obtain a graphene oxide dispersion; add 1 mL of 5 mg / mL to the graphene oxide dispersion Dendritic polyethyleneimine (purchased from SIGMA-ALDRICH company, product number 408727) aqueous solution, vigorously stirred at 180r / min for 30 minutes, sonicated at 200kHz for 15 minutes to obtain a uniform mixture; then add 0.1g to the above mixture Ciprofloxacin (purchased from Aladdin Reagent Company, product number C119326), stirred for 30 minutes, sonicated at 200kHz for 15 minutes, and then filtered on a CA microfiltration membrane for 12 hours. The graphene oxide film of floxacin used for drug sustained release (such as figure 2 ).

[0036] The graphene ox...

Embodiment 3

[0038] Example 3 Preparation of a graphene oxide film containing ciprofloxacin for sustained drug release using hyperbranched polyethyleneimine as a crosslinking agent

[0039] Add 10 mg of graphene oxide (purchased from Nanjing Xianfeng Nano Co., Ltd., product number XF002) into 100 mL of deionized water and sonicate for 2.5 hours to obtain a graphene oxide dispersion; add 1 mL of 10 mg / mL to the graphene oxide dispersion Hyperbranched polyethyleneimine (purchased from SIGMA-ALDRICH, product number 408727) aqueous solution, vigorously stirred at 180r / min for 30 minutes, ultrasonicated at 200kHz for 15 minutes, to obtain a homogeneous mixture; then add 0.1g to the above mixture Ciprofloxacin (Aladdin Reagent Company, product catalog number C119326), stirred for 30 minutes, sonicated at 200 kHz for 15 minutes, and then filtered on CA microfiltration membrane for 24 hours to obtain ciprofloxacin Graphene oxide film for sustained drug release.

[0040] The graphene oxide film for dru...

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Abstract

The invention discloses a method for preparing a graphene oxide film and a graphene oxide film product. The method comprises the following steps: mixing graphene oxide dispersion liquid and amino terminal-hyperbranched or dendritic polymer, carrying out suction filtering to prepare the graphene oxide film. The invention further discloses a method for preparing the graphene oxide film for sustained release of drug and a graphene oxide film product, and the method comprises the steps of mixing the graphene oxide dispersion liquid and the amino terminal-hyperbranched or dendritic polymer, adding a medicine with an aromatic nucleus into the mixed solution, and finally carrying out suction filtering. According to the method, the graphene oxide is crosslinked by means of the amino terminal-hyperbranched or dendritic polymer to form a flat lamellar film, so that the film has a relatively high film stability in an aqueous environment, the sustained-release controlled-release performance of drug can be improved, and the drug loading capacity of the film can be improved; and the graphene oxide film for sustained-release of drug is slowly released in a damp or aqueous environment and has the advantages of long maintaining duration and remarkable antibacterial effect.

Description

Technical field [0001] The invention relates to the field of medicine and chemical engineering, in particular to a preparation method and product of a graphene oxide film for slow drug release. Background technique [0002] Polymer film has a very broad application prospect in the transmission of biologically active molecules such as proteins and nucleic acids or small molecule drugs. The film can usually be used as a drug coating to cover implants, stents and wound sutures to control or stimulate Wait for the corresponding way to release the drug. As a drug delivery system, the polymer film can maintain a high drug concentration, enhance the activity of the medical agent and reduce the side effects of the drug. [0003] In 2004, Geim AK and Novoselov KS of the University of Manchester in the United Kingdom successfully prepared a single-atom or thin-layer two-dimensional atomic crystal-graphene by exfoliating highly oriented pyrolytic graphite (HOPG) by micromechanical force. It...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/34A61K9/70A61L27/34C08J5/18
Inventor 张林黄铁凡侯立安陈欢林
Owner ZHEJIANG UNIV
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