26results about How to "Improve penetration efficiency" patented technology

The present application relates to the technical field of medical apparatus, particularly relates to wearable and vibration control nail base nanocrystal microneedle transdermal drug delivery device, including shell, both sides of the shell are provided with a group of positioning notches respectively, a group of positioning notches are provided with a threaded hole respectively, the inside four corners of the shell are provided with a group of support seats respectively, still include controller assembly, nanocrystal microneedle assembly, vibration assembly, power supply assembly and fixed ring assembly, the controller assembly is detachably installed in the shell, the shell is provided with vibration assembly and battery assembly respectively, the bottom end of the shell is detachably provided with nanocrystal microneedle assembly, the both ends of the fixed ring assembly are detachably connected with a group of positioning notches respectively, the nanocrystal microneedle assembly is used for lightly pricking nail base epidermis and nail plate edge to form microchannel, the power supply assembly provides power for vibration assembly and controller assembly;It makes drug directly contact focus.

This invention discloses a portable low-temperature plasma device based on a Laval nozzle structure and its application, belonging to the field of plasma technology application technology. Specifically, it includes (1) the construction of the device; and (2) the use of the device for fungal eradication treatment and transdermal drug delivery enhancement treatment. The beneficial effects achieved by this invention are as follows: This invention is the first to apply the Laval nozzle structure to a portable low-temperature plasma device. The results show that the device can effectively improve the plasma jet performance and active particle content, significantly improve the treatment effect of fungal infections of the skin and nails and the transdermal drug penetration efficiency, while solving the problems of large size, reliance on external power supply, and complex operation of traditional plasma devices. Therefore, using this invention for the treatment of fungal infections of the skin and nails and for enhanced transdermal drug delivery has advantages such as ease of operation, high safety, non-invasiveness, and high efficiency, and thus has potential application prospects in the field of skin disease treatment and transdermal drug delivery.

This invention belongs to the field of cosmetic technology and discloses a composition containing polypeptides, its preparation method, and its application. The composition provided by this invention comprises: polypeptides and a solubilizing and penetration-enhancing complex; the polypeptides include at least one selected from Codonopsis pilosula cyclic peptide B, conopeptide, carnosine, acetyl tetrapeptide-5, acetyl hexapeptide-8, and nonapeptide-1; the solubilizing and penetration-enhancing complex comprises the fermentation product filtrate of Kluyveromyces lactis / Ganoderma lucidum fruiting body extract, polyols, polysorbate, and ferulic acid. The composition provided by this invention, through the synergistic effect between its components, can effectively improve the solubility and stability of the polypeptides, preventing precipitation or exudation, while effectively promoting the transdermal absorption of the polypeptides; the composition provided by this invention has excellent antioxidant and anti-aging effects.

The utility model discloses irrigation equipment for landscaping, which belongs to the technical field of landscaping equipment and comprises a base, universal wheels are rotatably connected to four corners of the bottom of the base, a push rod is fixedly connected to the outer side of the base, a supporting block is fixedly connected to the top of the base, and a water bucket is arranged at the top of the base. A water adding opening is formed in the top of the water bucket, an input pipe is fixedly connected to the outer side of the water bucket, a water pump is fixedly connected to the top of the base, an output pipe is fixedly connected to the output end of the water pump, a spray head is fixedly connected to the end, away from the water pump, of the output pipe, a shaking mechanism is arranged on the periphery of the water bucket, and a soil piercing mechanism is arranged at the bottom of the base. The shaking mechanism prevents the nutrient solution in the bucket from precipitating, the irrigation uniformity is improved, the soil loosening mechanism assists in achieving soil loosening, the hardening problem is solved, and the water permeation efficiency is improved.

The utility model relates to the field of laying devices, and discloses a metal mine surface matrix layer modifier laying device which comprises a frame, a spraying mechanism is arranged on the upper surface of the frame and comprises a water pump fixedly connected to the rear end of the upper surface of the frame, and the output end of the water pump is fixedly connected with a water outlet pipe. The end, away from the water pump, of the water outlet pipe is fixedly connected with a connecting pipe, the rear end of the connecting pipe is fixedly connected with a rear spraying frame, and the end, away from the rear spraying frame, of the connecting pipe is fixedly connected with a front spraying frame. According to the device, a water pump in the spraying mechanism is matched with a rear spraying frame and a front spraying frame to spray an improver to the land, the land sprayed for the first time can be turned over through a ploughing frame after spraying is conducted through a first spraying head, and then the rear spraying frame conducts spraying for the second time; through the mechanism, the spraying efficiency of the equipment can be effectively improved, and the permeation efficiency of the modifier is improved.

The application discloses a kind of service concrete penetration type anti-freezing protective material and preparation method thereof, belong to concrete protection technical field.The composition of the protective material is: organic silicon modified penetration enhancement component 30~60 parts, nano-crystalline component 10~30 parts, microbial self-repairing component 5~20 parts, composite silane coupling agent 2~8 parts, penetration accelerator 1~5 parts, stabilizer 0.5~3 parts, defoaming agent 0.1~1 part, water 10~50 parts.The application constructs "hydrophobic barrier-crystallization densification-microbial self-repairing" triple synergistic protection system, solves the technical bottleneck that existing concrete protective material penetration depth is shallow, long-acting protection stability is poor, has no active crack repair capacity, construction is complicated, and on-site adaptability is poor.The application preparation process is simple, product performance is stable, cost-effective, can long-acting improve the frost resistance of concrete structure in severe cold area.

The application discloses a kind of hydrogel microneedle patches based on bletilla striata polysaccharide composite engineered exosome and its preparation method and application, belong to the technical field of biomedical materials, with bletilla striata polysaccharide and methacrylated hyaluronic acid as matrix, and the hydrogel microneedle with excellent mechanical properties is prepared.The natural polyphenol caffeic acid is used to modify the bone marrow mesenchymal stem cell exosome, and the engineered exosome is loaded on the microneedle tip by centrifugation.The strong antioxidant capacity of caffeic acid is used to protect the structure of exosome, and a synergistic system is formed, combined with the antibacterial and anti-inflammatory properties of the bletilla striata polysaccharide matrix itself, the diabetic wound microenvironment can be improved from multiple dimensions such as bacteriostasis, antioxidant, anti-inflammatory and pro-angiogenesis.The preparation process of the application is simple and controllable, the product has high biological safety, and the active ingredients can be delivered precisely and minimally invasively, providing an efficient and safe solution for diabetic chronic wound repair.

The utility model discloses a visual minimally invasive thrombolysis catheter system which comprises a catheter body and a tail end structure, the tail end structure is arranged at the front end of the catheter body, and the tail end structure comprises a medicine releasing body, an ultrasonic micro-vibration head and a miniature wide-angle lens; the ultrasonic micro-vibration head is of an annular structure, and the ultrasonic micro-vibration head of the annular structure is connected with an external ultrasonic generator through a wire. The miniature wide-angle lens is arranged at the front end of the ultrasonic micro-vibration head, the miniature wide-angle lens is connected with external display equipment through the optical fiber, and the wire and the optical fiber extend in a cavity in the catheter body; the drug release body is of an annular structure, and the ultrasonic micro-vibration head and the miniature wide-angle lens are located on the outer side of the front end of the drug release body of the annular structure. According to the utility model, the visualization of the thrombus position is realized, the accuracy of the drug release position is ensured, the thrombolysis efficiency is improved, the thrombolysis time is shortened, the complication risk is reduced, and the visualization of the drug thrombolysis effect can be realized.

This application discloses an aqueous stripping solution, its preparation method, and its application, belonging to the field of photoresist technology. The aqueous stripping solution comprises amines, alcohol ether solvents, polyols, surfactants, and metal resists. The amines swell the photoresist, the alcohol ether solvents have good permeability, significantly reducing the adhesion between the photoresist and the substrate, and the surfactants reduce the surface tension at the photoresist-substrate interface. Combining the amines, alcohol ether solvents, and surfactants enhances the penetration efficiency of the stripping solution into the photoresist, accelerates the photoresist stripping rate, and thus improves the photoresist stripping effect, thereby increasing product yield. Furthermore, the polyols can form hydrogen bonds with hydrogen atoms in water molecules, binding water molecules, reducing water evaporation, and maintaining high stability of the stripping solution during heating, extending its service life. In addition, the metal resists reduce damage to the metal substrate caused by the stripping solution.

The utility model discloses a kind of embedding boxes for congenital megacolon specimen, it is related to the field of tissue embedding technology.It includes box body with filter hole, circular ring, tight knob column, helical segmentation strip and box cover.Circular ring is fixed along inside of side plate, helical segmentation strip is coiled in spiral, one end is connected with the tight knob column of center, the other end is fixed in circular ring, can adjust interval with knob column rotation to hold or release specimen.Tight knob column contains shaft sleeve, shaft cap and split type knob spoon, through hexagonal structure cooperation and the bistable clamping of arc spring and clamping groove, the clutch and stable rotation of knob spoon and shaft cap are realized, control helical strip tightness.Box body, circular ring, helical strip etc.are provided with round hole to ensure reagent penetration, box cover buckle sealing, label area is provided in front.The design realizes specimen integration fixation, maintains morphological continuity, simplifies material taking, embedding process, improves pathological diagnosis efficiency and accuracy.

This invention relates to the field of mixing equipment technology, specifically to a microwave-high pressure synergistic mixing device for mica paper binder. It includes a support frame, on which a horizontally arranged mixing tank is mounted. A main motor is mounted on the support frame, and the output end of the main motor is connected to a stirring shaft extending into the mixing tank. A booster pump is mounted on the support frame, and the output end of the booster pump extends into the mixing tank. A microwave heater is mounted on the top of the mixing tank, with its microwave output end facing the interior of the mixing tank. A stirring paddle is connected to the outer wall of the stirring shaft, and an elastic scraper is connected to the stirring paddle. This invention, by integrating microwave bulk heating and a pressurized environment, prevents wall adhesion and bubble generation from the source. Its elastic scraper has a periodic self-cleaning function, which can powerfully remove its own and the tank wall's adhering materials, reducing secondary accumulation. Combined with a dynamic flow guiding design, it forms a high-intensity changing flow field, achieving efficient material dispersion.

This utility model discloses a drilling sleeve device for mining, including a header, a drill barrel, a spindle, a bracket, a feed header, a drive mechanism, and a hydraulic cylinder. The drill barrel is movably installed inside the header. The front end of the spindle is coaxially connected to the drill barrel via a center drill. The bracket is rotatably connected to the spindle via bearings, and both ends of the bracket are slidably connected to the header. The feed header is fixedly connected to the header. The drive mechanism includes a motor and a slide block. The motor is fixed to the slide block, and the motor output shaft is connected to the spindle. The slide block is slidably connected to the feed header. The cylinder body of the hydraulic cylinder is fixed inside the header, and the piston rod is connected to the motor of the drive mechanism. The base is fixedly connected to the feed header. This utility model adopts a double-protrusion-slide groove fit between the bracket and the slide block to form a two-stage axial guide. It synchronously constrains radial displacement from the middle of the spindle and the drive end, significantly suppressing drilling vibration, reducing wear on the drill barrel and drill rod, and improving drilling accuracy and equipment life.

The novel low-carbon recycled aggregate surface strengthening micro-powder carbon mineralization integrated equipment disclosed by the application comprises a rack, a carbonization cylinder one and a carbonization cylinder two, the carbonization cylinder one is horizontally installed on the rack through vibration, the top surface of the carbonization cylinder one is provided with a lower hopper, the top surface of the carbonization cylinder one is provided with an inlet, the lower hopper is provided with a buffer sealing structure, the bottom surface of the carbonization cylinder one is provided with a first discharge port and a second discharge port, the first discharge port is provided with a filter screen, the lower portion of the carbonization cylinder one is provided with the two carbonization cylinder two, the upper ends of the two carbonization cylinder two are in one-to-one correspondence with the first discharge port and the second discharge port and are communicated with the first discharge port and the second discharge port, the carbonization cylinder two is provided with a stirring rod, the lower ends of the two carbonization cylinder two are provided with lower outlets, the top surfaces of the two carbonization cylinder two are respectively provided with an air inlet and a liquid inlet, the carbonization cylinder one is provided with a rod body and a spiral blade, the rod body is provided with a rubbing part, and the surface of the rubbing part is provided with a stripping surface. Compared with the prior art, the carbonization effect of the aggregate is better.

The invention relates to an integrated environmental control all-in-one machine with a fresh air cold and heat exchange function in the technical field of air conditioner total heat exchange. The integrated environmental control all-in-one machine comprises a total heat exchanger and a preprocessor. The preprocessor comprises a pre-dehumidification box body and a heat exchanger, the pre-dehumidification box body is communicated with a fresh air inlet of the total heat exchanger, and the heat exchanger is arranged in the pre-dehumidification box body and is in heat exchange connection with a pipeline which is output from an air conditioner compressor to a radiator; the pre-dehumidification box body is composed of box walls which selectively permeate water molecules. The preprocessor is additionally arranged to dehumidify air just entering an inlet of a fresh air system, heat is extracted from a cooling liquid conveying pipeline compressed by an air conditioner compression pump to heat fresh air entering a pre-dehumidification box body, a large temperature difference is generated inside and outside the pre-dehumidification box body, and the permeation efficiency of water molecules is improved; therefore, the fresh air system can obtain fresh air with the humidity lower than the environment humidity value, and extra energy does not need to be consumed.

This invention discloses a protein-based nanomaterial, its preparation method, and its application as a nucleic acid delivery carrier. The preparation method includes: modifying BSA with 1,6-hexanediamine as a modifier; dissolving the obtained BSA-NH2 and 2-iminothionyl pentane hydrochloride in PBS buffer to obtain a mixed solution; dissolving dodecyl acrylate and triethylamine in dimethyl sulfoxide and adding them to the mixed solution for stirring at room temperature; and dialysis purification. This invention grafts low-density dodecyl acrylate hydrophobic carbon chains onto the surface of cationic BSA to construct a bifunctional carrier with both charge-mediated encapsulation and transmembrane delivery capabilities. The hydrophobic chains mimic the hydrophobic environment of biological membranes, reducing the energy barrier and enhancing affinity to achieve efficient internalization, promoting the interaction between the carrier and the cell membrane; while amino modification endows it with pH-responsive dissociation ability, thereby enabling endosome escape.

The present application relates to hydrogen purification technical field, a kind of high-efficiency stable palladium tube hydrogen purifier, comprising: shell assembly, shell assembly is made of shell, heat preservation layer and inner container, and heat preservation layer is filled in the gap between shell and inner container, the middle of one end of inner container is fixed with the original gas inlet pipe extending out of shell, and the one end of original gas inlet pipe is fixedly installed with inlet valve;Feed pretreatment component, feed pretreatment component is set in the one end of inner container close to original gas inlet pipe, and its top extends to the top side of shell;End cap, end cap is fixedly installed in the one end of shell away from original gas inlet pipe, and the middle of end cap is fixed with hydrogen outlet pipe.The present application realizes the multistage depth purification of hydrogen, greatly improves the recovery rate and purity of hydrogen after purification, simultaneously, high-efficiency breaks the laminar boundary layer formed by raw material gas on the surface of palladium tube body, reduces the resistance of hydrogen molecules from raw material gas main body to spread to the surface of palladium tube, and realizes the double energy saving of tail gas waste heat recovery and tail gas kinetic energy utilization.

The utility model discloses a tempered laminated hollow LED reverse pasting lamp photovoltaic glass, relates to the photovoltaic glass technology field, and comprises an installation assembly, the installation assembly comprises a PVB film, an aluminum heat radiation sheet, via holes, an installation support, heat conduction silicone grease, a clamping groove and an LED chip, the aluminum heat radiation sheet is pasted on the back side of the PVB film, the via holes are arranged on the PVB film in an array mode, and the installation support is provided with the LED chip. A mounting bracket penetrates through the interior of the via hole, and heat-conducting silicone grease is filled in a gap between the mounting bracket and the via hole. According to the tempered laminated hollow LED reversely-pasted photovoltaic glass provided by the invention, the PVB film with high mechanical strength is selected as the substrate to enhance the deformation resistance, and the heat conduction silicone grease is filled in the gap between the mounting bracket and the via hole in the PVB film, so that the heat generated during the operation of the LED chip is conducted to the aluminum cooling fin on the back surface of the PVB film through the heat conduction silicone grease; the heat dissipation area can be effectively guaranteed, the heat dissipation performance is improved, meanwhile, the sealing performance of the connecting position can be guaranteed, and rainwater and impurities are prevented from permeating.

This invention provides a spiral-type built-in heating device, belonging to the technical field of heating devices. It includes a support frame, a first ring frame and a cable reel mounted on the support frame, and a heating cable mounted on the cable reel. This invention utilizes the rotation of the cable reel in two different directions to simultaneously release the heating cable and rotate the cable itself. Combined with multiple spiral segments on the outer side, the heating cable spirally enters the inner wall of the pipe. This allows for rapid penetration of the viscous medium within the pipe during insertion, avoiding the bending that can occur with direct insertion. This reduces the difficulty of inserting the heating cable into the pipe, allowing it to smoothly reach the appropriate insertion length and thus quickly heat the pipe. Simultaneously, multiple guiding components in the guide block intermittently guide the heating cable during its extension, reducing friction on the spiral segments, increasing their service life, and improving the efficiency of the heating cable insertion.

The utility model discloses a cold and dry method online sampling system, and belongs to the technical field of sampling of environment-friendly flue gas emission continuous monitoring systems of coal chemical industry and thermal power plants. The cold dry method on-line sampling system comprises a heating probe rod, one end of the heating probe rod is provided with a filter, one end of the filter is provided with a sampling probe, two sides of the sampling probe are respectively provided with a compressed air control valve and a separation tank, one end of the sampling probe is communicated with a three-way joint, one side of the three-way joint is provided with a peristaltic pump, and the other side of the three-way joint is provided with a water pump. A phosphoric acid titration tank is arranged on the same side of the peristaltic pump, a heat tracing sampling pipe is arranged on one side of the three-way connector, a condenser is installed at one end of the heat tracing sampling pipe, a drying pipe is installed at one end of the condenser, a vacuum sampling pump is communicated with one end of the drying pipe, a three-way switching valve is arranged at one end of the vacuum sampling pump, and the other end of the three-way switching valve is communicated with the three-way connector. And one side of the three-way switching valve is communicated with a calibration three-way valve.

This invention relates to the field of functional film preparation technology, specifically to a method for preparing a wear-resistant, stain-resistant, transparent, and slip-resistant film, comprising a wear-resistant and hardening primer, a slip-resistant and transparent intermediate layer, and a wear-resistant and stain-resistant topcoat. The wear-resistant and hardening primer comprises hydroxyethyl acrylate modified amino resin, polyurethane oligomer, trimethylolpropane triacrylate, 1,6-hexanediol diacrylate, a mixed solvent, KH560 silane coupling agent, nano-alumina, polytetrafluoroethylene micropowder, photoinitiator 1173, silicone leveling agent, and isocyanate curing agent. The mixed solvent is composed of ethyl acetate and ethanol. This invention employs a three-layer synergistic coating system, significantly improving the bonding stability between the coating and the substrate, as well as between the coating layers, through functional differentiation design and interface optimization of the primer, intermediate layer, and topcoat.

The invention relates to the technical field of cattle and sheep breeding, in particular to a cattle and sheep breeding circulating water drinking system with self-cleaning and disinfecting functions, which comprises a mounting shell, a disinfecting water tank is mounted on the left side in the mounting shell, a feeding main body is mounted on the left side of the disinfecting water tank, and a control main body is mounted on the top of the mounting shell. The device comprises a mounting shell, a liquid inlet valve is mounted on the left side of the mounting shell, a charging device is mounted on the right side of the mounting shell, and a circulating pump is mounted on the lower portion of the right side in the mounting shell, the mounting shell, the control main body, the disinfection water tank, the liquid inlet valve, the circulating pump, a water drinking device, a mounting plate, the charging device and a feeding main body are arranged, and a disinfectant can be fed into the disinfection water tank through the feeding main body; the drinking water is driven to circulate through the circulating pump and the water drinking device, it is guaranteed that no virus or bacterium is bred in the long-time drinking process of the drinking water, the growth of the cattle and the sheep is affected, a nutrient solution or medicine can be injected into the drinking water through the feeding device, and the cattle and the sheep are healthier in the breeding process.

The invention belongs to the technical field of cosmetics, and particularly relates to a ginsenoside RG1-CK supramolecular co-loading permeation-enhancing nano-composite, a preparation method thereof and application of the ginsenoside RG1-CK supramolecular co-loading permeation-enhancing nano-composite in cosmetics. According to the invention, the difference and generality of Rg1 and CK molecular structures are utilized, the two active components are driven to spontaneously form an ordered aggregate by means of intermolecular acting force by precisely regulating and controlling self-assembly reaction conditions, and efficient co-loading in a non-physical entrapment mode is realized. The nano-composite effectively improves the skin permeability and bioavailability of ginsenoside Rg1, so that the ginsenoside Rg1 and high-permeability CK can reach the deep layer of the skin together, the main application obstacle of the ginsenoside Rg1 is overcome, and co-loading and synchronous delivery of the two active components Rg1 and CK in a single nano-carrier are realized; and it is ensured that the components act on target cells at the same time according to the preset optimal synergistic ratio, so that the anti-aging and anti-oxidation synergistic effect of the components is maximized.

The invention discloses a self-powered small-molecule traditional Chinese medicine ion introduction acupoint patch which sequentially comprises an elastic backing layer, a piezoelectric energy collection layer, a drug-loaded conductive hydrogel layer and a release protection layer from outside to inside, the piezoelectric energy collection layer comprises a rectifier module, and the drug-loaded conductive hydrogel layer is arranged to be a solid ionic gel or semi-interpenetrating network hydrogel film. According to the self-powered small-molecule traditional Chinese medicine iontophoresis acupoint patch and the preparation method thereof, a microencapsulation technology is abandoned, free-state traditional Chinese medicine small molecules are directly adopted, and deep skin penetration is achieved through the high electrophoresis mobility of the free-state traditional Chinese medicine small molecules under a high-voltage electric field; through the design of an integrated flexible rectifying circuit or an asymmetric electrode, piezoelectric alternating current is converted into pulsating direct current, it is ensured that charged medicine is always subjected to one-way electric field force pointing to the deep layer of the skin, and meanwhile low-cost and large-scale manufacturing is achieved.

The application discloses a kind of composite coating diaphragm and its preparation method and secondary battery, the composite coating diaphragm includes base film and the composite functional coating being combined on the surface of base film, the composite functional coating includes the first functional coating being relatively close to base film and the second functional coating being relatively far from base film, the porosity of first functional coating is less than the porosity of second functional coating, and raw material component all include cis-1,4-polybutadiene and polyethylene glycol segment are double grafted with modified nanocellulose and gas phase aluminum oxide.By constructing the diaphragm coating with gradient pore structure, and combining advanced material modification technology, so that the composite coating diaphragm set high thermal stability, excellent electrolyte wettability and low temperature adaptability in one, still can keep stable structure and interface characteristics under extreme temperature working condition, so as to have good scalability and industrial application prospect, be applicable to the development and application demand of high-performance lithium ion battery and next-generation energy storage device.

The application provides a kind of bionic flexible humidity sensing composite material and its preparation method and application.The bionic flexible humidity sensing composite material is composed of flexible substrate, conductive doped layer and surface active modification layer; wherein, the flexible substrate is polyvinyl alcohol as base material, formed by electrospinning into micron fiber network; conductive material is added in the electrospinning process to form the conductive doped layer, and surfactant is added to form the surface active modification layer.The preparation method is simple, and the main steps only involve electrospinning process, and the material preparation has strong repeatability; and the raw materials used are mainly water-soluble polyvinyl alcohol, without introducing organic solvent, more environmentally friendly.The pore channels distributed on the bionic flexible humidity sensing composite material prepared by the application are antler-like porous structure, the pore channel plane size is 0.5-2 μm, near elliptical, and multiple pore channels form micron-level breathable network, thereby improving the humidity permeation efficiency and realizing high-efficiency air permeation function.