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Core-shell structure nano particle and preparation method thereof

A nanoparticle, core-shell structure technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and inorganic non-active ingredients, etc., and can solve problems such as the inability to achieve effective controlled release of active drugs.

Inactive Publication Date: 2020-02-11
深圳碳十四科技创新有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when the carrier substance is hydrolyzed or degraded, the active drug located in the core area will flow out rapidly at the same time, and the effective controlled release of the active drug cannot be achieved.

Method used

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  • Core-shell structure nano particle and preparation method thereof
  • Core-shell structure nano particle and preparation method thereof
  • Core-shell structure nano particle and preparation method thereof

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preparation example Construction

[0042] see figure 2 , the present invention also proposes a method for preparing nanoparticles with a core-shell structure, including the nanoparticles with the core-shell structure. The nanoparticles with the core-shell structure refer to the above-mentioned embodiments. All the technical solutions at least have all the beneficial effects brought by the technical solutions of the above embodiments, and will not be described here one by one. The preparation method of the core-shell nanoparticle comprises the following steps:

[0043] preparing a first aqueous phase solution, the first aqueous phase solution comprising a water-soluble substance and an active drug;

[0044] preparing an organic phase solution, the organic phase solution includes a fat-soluble polymer;

[0045] mixing the first aqueous phase solution and the organic phase solution to form a first water-in-oil emulsion;

[0046] preparing a second aqueous phase solution, mixing the second aqueous phase solution ...

Embodiment 1

[0061] A method for preparing nanoparticles with a core-shell structure, comprising the following steps: first, mixing ethyl orthosilicate, ethyl silicate, water and hydrochloric acid solution at normal temperature, so that ethyl orthosilicate and ethyl silicate Esters were hydrolyzed to produce a clear silicic acid solution; then, antibiotics were dissolved into the silicic acid solution to prepare the first aqueous phase solution (S1); then, 1 volume of the first aqueous phase solution (S1) was added to 5 volumes of In the dichloromethane solution of polylactic acid with a concentration of 20mg / ml, ultrasonic emulsification for 1 minute to obtain the first emulsion (R1); then add 1 volume of the first emulsion (R1) to 2 volumes of the second aqueous phase solution In (S2), the second emulsion (R2) was obtained by ultrasonic emulsification for 2 minutes; finally, the second emulsion (R2) was stirred for 4 hours, filtered and dried to obtain nanoparticles with core-shell struct...

Embodiment 2

[0064] A method for preparing nanoparticles with a core-shell structure, comprising the following steps: first, dissolving chitosan in a weak acid to obtain a chitosan aqueous solution with a mass fraction of 1%; then, dissolving antibiotics into the above-mentioned chitosan aqueous solution, Prepare the first aqueous phase solution (S1); then, add 1 volume of the first aqueous phase solution (S1) to 5 volumes of a dichloromethane solution of polyethylene glycol-lactic-co-glycolic acid copolymer with a concentration of 30 mg / ml In the process, ultrasonic emulsification for 2 minutes to obtain the first emulsion (R1); then add 1 volume of the above-mentioned first emulsion (R1) to 4 volumes of the second aqueous phase solution (S2), and ultrasonic emulsification for 1 minute to obtain the second emulsification solution (R2); finally, the above-mentioned second emulsion (R2) was stirred for 4 hours, filtered and dried to obtain core-shell structure nanoparticles. Wherein, in the...

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Abstract

The invention discloses a core-shell structure nano particle and a preparation method thereof. The core-shell structure nano particle comprises a water phase core and an organic phase shell, wherein the water phase core is composed of an aerogel and a plurality of active drug particles, and the multiple active drug particles are dispersed in the aerogel; and the organic phase shell covers the surface of the water phase core. It is understandable that through the technical scheme of the core-shell structure nano particle, effective controlled release of active drugs can be realized.

Description

technical field [0001] The invention relates to the technical field of core-shell structure and preparation thereof, in particular to a core-shell structure nano particle and a preparation method thereof. Background technique [0002] Drug release system is a new field of drug development. In this system, active drugs such as water-soluble drugs and nanoparticles are combined with carriers and released into the external environment in a controlled manner (rate), so as to achieve effective treatment of diseases. At present, the common drug controlled release system adopts the shell-core structure. The shell-core structure means that the active drug (core) is wrapped in the core area by the carrier substance (shell). The release rate of the active substance is mainly adjusted by the molecular characteristics of the carrier substance and The wall thickness of the shell is achieved. However, when the carrier substance is hydrolyzed or degraded, the active drug located in the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/10A61K47/38A61K47/36A61K47/32A61K47/04A61K47/02A61K47/34
CPCA61K9/5115A61K9/5138A61K9/5146A61K9/5153A61K9/5161A61K9/5192
Inventor 黄文飞
Owner 深圳碳十四科技创新有限公司
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