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Method for preparing composite chitosan nanogel immobilized multi-layer capsules

A nanogel and multi-layer capsule technology, which is applied in the direction of microcapsule preparation, capsule delivery, microsphere preparation, etc., can solve the problems of reducing the clinical applicability of nanogel, adhesion and precipitation of nanogel, and reducing the efficiency of drug delivery, etc. Achieve the effects of good economic development potential, convenient operation and low manufacturing cost

Inactive Publication Date: 2014-04-30
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the prepared chitosan-carboxymethyl chitosan nanogel is unstable under acidic conditions, and the chitosan-carboxymethyl chitosan nanogel will be destroyed by gastric acid during oral administration, resulting in the inclusion of Part of the drug loaded is released early, which reduces the drug delivery efficiency
At the same time, in the aqueous environment, chitosan-carboxymethyl chitosan nanogels will gradually aggregate and produce precipitation, while chitosan-carboxymethyl chitosan nanogels will be freeze-dried and then suspended, will The phenomenon of nanogel adhesion and precipitation occurs, which greatly reduces the clinical applicability of the nanogel

Method used

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  • Method for preparing composite chitosan nanogel immobilized multi-layer capsules

Examples

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Comparison scheme
Effect test

Embodiment 1

[0017] 10mL, 0.25% (w / v) chitosan-carboxymethyl chitosan nanogel was added to 10mL, 0.5% (w / v) sodium alginate solution, 90W ultrasonic for 5 minutes, the mixed solution Add it into 1% calcium chloride solution (w / V) under 5Kv high-voltage electric field, and solidify for 30 minutes. Rinse with distilled water 3 times to obtain core capsules. Immerse the core capsule in 0.5% (w / v) sodium alginate solution, let it stand for 5 minutes, filter off the excess liquid, put the rubber ball into the mixture of 0.5mL Tween-80 and 200mL liquid paraffin, 500 rpm Stir for 10 minutes per minute, add 50 mL of 1% (w / v) calcium chloride solution, continue stirring at 500 rpm for 30 minutes, rinse with distilled water for 3 times to obtain coated capsules, freeze-dry to obtain a layer of capsules By this product.

Embodiment 2

[0019] 15mL, 0.3% (w / v) chitosan-carboxymethyl chitosan nanogel was added to 15mL, 1% (w / v) sodium alginate solution, 90W ultrasonic 8 minutes, mixed solution in Add it into 2% (w / v) calcium chloride solution under 8Kv high-voltage electric field, and solidify for 30 minutes. Rinse with distilled water 3 times to obtain core capsules. Immerse the core capsule in 1% (w / v) sodium alginate solution, let it stand for 5 minutes, filter off the excess liquid, put the rubber ball into the mixture of 1mL Tween-80 and 200mL liquid paraffin, 500 rpm Stir for 10 minutes, add 50 mL of 2% (w / v) barium chloride solution, continue stirring at 500 rpm for 30 minutes, rinse with distilled water for 3 times to obtain coated capsules, repeat coating 5 times, freeze-dry, that is 5-layer coated product is available.

Embodiment 3

[0021] 10mL, 0.2% (w / v) chitosan-carboxymethyl chitosan nanogel was added to 10mL, 2% (w / v) sodium alginate solution, 90W ultrasonic 10 minutes, the mixed solution Add it into 3% calcium chloride solution under 10Kv high-voltage electric field, and solidify for 30 minutes. Rinse with distilled water 3 times to obtain core capsules. Submerge the core capsule in 1% (w / v) sodium alginate solution, let it stand for 5 minutes, filter off the excess liquid, put the rubber ball into the mixture of 0.8mL Span-80 and 200mL liquid paraffin, 500 Stir for 10 minutes at rpm, add 50 mL of 3% (w / v) calcium chloride solution, continue stirring at 500 rpm for 30 minutes, rinse with distilled water 3 times to obtain coated capsules, repeat coating 15 times, freeze-dry , You can get 15 layers of coated products.

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Abstract

The invention discloses a chitosan nanogel immobilized capsule preparation technology used for oral drug delivery and discloses a method for preparing composite chitosan nanogel immobilized multi-layer capsules. The method comprises the step of fixing chitosan-carboxymethyl chitosan composite nanogel which is uniformly dispersed in an aqueous solution to multi-layer sodium alga acid capsules through an ionotropic gelation process. The multi-layer capsules have high pH responsiveness and are stable in structure in a gastric acid environment, and complete nanogel can be rapidly released in a neutral and faintly alkaline intestinal environment. The composite chitosan nanogel can be effectively prevented from being disintegrated in advance in the acid environment, and the oral drug delivery efficiency is improved. The method can be used for medical biological materials and drug carriers and has high research and development and utilization prospect.

Description

technical field [0001] The invention belongs to the field of biomaterials and relates to a preparation method of a chitosan composite nanogel immobilized multilayer capsule. Background technique [0002] Chitosan is a kind of natural cationic biological polysaccharide, which has the advantages of large amount of resources, biodegradability, adhesion to intestinal mucosa, safety and non-toxicity. It is a good material for developing medical oral drug delivery carrier. In the existing research inventions, it has been reported that chitosan-carboxymethyl chitosan nanogels were prepared by polymer coacervation method, which can reversibly open the tight junctions between small intestinal epithelial cells and promote the The absorption of drugs in the whole intestinal tract enhances the oral bioavailability of drugs. However, the prepared chitosan-carboxymethyl chitosan nanogel is unstable under acidic conditions. Part of the drug loaded is released early, which reduces the dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/48C08J7/04B01J13/04
Inventor 陈西广冯超程晓杰孔明
Owner OCEAN UNIV OF CHINA
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