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Composite material for treating dentine hypersensitivity and preparation method thereof

A composite material and dentin technology, which is applied in the field of composite materials for the treatment of dentin sensitivity and its preparation, can solve the problems of low blockage rate, ineffectiveness for patients, weak binding force, etc.

Active Publication Date: 2012-12-19
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Experimental studies of these materials have shown a certain effect of blocking dentinal tubules, but there are problems such as long time required for action, low blocking rate, unstable clinical curative effect, short maintenance time, and even ineffective for some patients.
Analyze the reasons; one of the possible important reasons is that the diameter of the dentinal tubules is only 3-4 μm near the pulp cavity and 1 μm near the enamel dentin junction. Poor fit or weak bonding

Method used

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  • Composite material for treating dentine hypersensitivity and preparation method thereof
  • Composite material for treating dentine hypersensitivity and preparation method thereof
  • Composite material for treating dentine hypersensitivity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the preparation of composite material

[0031] (1) Preparation of mesoporous silica nanoparticles

[0032] The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 8504: 2.55: 8.13 (molar ratio); Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was filtered and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and placed in a crucible , Calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores, the pore volume was 0.84cm 3 / g, the pore di...

Embodiment 2

[0048] Embodiment 2, the preparation of composite material

[0049] (1) Preparation of mesoporous silica nanoparticles

[0050] The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 4859: 2: 8.13 (molar ratio); Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was filtered and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and placed in a crucible , and calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores and a pore volume of 0.89 cm 3 / g, the pore ...

Embodiment 3

[0058] Embodiment 3, the preparation of composite material

[0059] (1) Preparation of mesoporous silica nanoparticles

[0060]The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 9719: 2.55: 8.13 (molar ratio); Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was filtered and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and placed in a crucible , and calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores and a pore volume of 0.81 cm 3 / g, the por...

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Abstract

The invention provides a composite material for treating dentine hypersensitivity and a preparation method thereof. The method comprises the following steps: (1) mixing mesoporous silica nanometer particles, calcium salt and water to obtain a mixture, drying and then calcining the mixture to obtain calcium-carried mesoporous silica nanometer particle microspheres; (2) mixing the mesoporous silica nanometer particles and a phosphoric acid aqueous solution to obtain a mixture, drying and then calcining the mixture to obtain phosphor-carried mesoporous silica nanometer particle microspheres; and (3) mixing calcium-carried mesoporous silica nanometer particle microspheres, phosphor-carried mesoporous silica nanometer particle microspheres and the water to obtain the composite material for treating dentine hypersensitivity. The composite material provided by the invention is toothpaste-like, can be uniformly smeared on tooth surface with dentine hypersensitivity symptoms by using medical small brush head, and can relatively deeply seal exposed dentinal tubules, so as to isolate external stimulation to the oral and achieve the effect of treatment of dentine hypersensitivity.

Description

technical field [0001] The invention relates to a composite material for treating dentin sensitivity and a preparation method thereof. Background technique [0002] Dentin hypersensitivity disease is mainly caused by irritation caused by exposure of dentine tubules to the oral environment. At present, the ideas for treating dentin sensitivity can be roughly divided into two categories: one is based on the theory of nerves and dentin fiber conduction theory, using toothpaste or varnishes containing potassium compounds such as potassium nitrate and potassium chloride to reduce the The sensitivity of the nerve endings, thereby reducing its response to external stimuli; the second type is based on hydrodynamics, reducing the diameter of the dentinal tubules, closing the opening of the dentinal tubules, and reducing the permeability of the dentine to reduce and avoid dentin. Liquid flow within the essence. The second type of method has been considered to be the fundamental way ...

Claims

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Application Information

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IPC IPC(8): A61K6/027
Inventor 蔡强史颖田力丽
Owner TSINGHUA UNIV
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