Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composite material for treating dentine hypersensitivity and preparation method thereof

A technology of composite materials and dentin, which is applied in the field of composite materials and its preparation for the treatment of dentin sensitivity, and can solve the problems of low blocking rate, ineffectiveness for patients, and weak bonding force, etc.

Active Publication Date: 2014-03-19
TSINGHUA UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Experimental studies of these materials have shown a certain effect of blocking dentinal tubules, but there are problems such as long time required for action, low blocking rate, unstable clinical curative effect, short maintenance time, and even ineffective for some patients.
Analyze the reasons; one of the possible important reasons is that the diameter of the dentinal tubules is only 3-4 μm near the pulp cavity and 1 μm near the enamel dentin junction. Poor fit or weak bonding

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composite material for treating dentine hypersensitivity and preparation method thereof
  • Composite material for treating dentine hypersensitivity and preparation method thereof
  • Composite material for treating dentine hypersensitivity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the preparation of composite material

[0031] (1) Preparation of mesoporous silica nanoparticles

[0032] The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 8504: 2.55: 8.13 (molar ratio); Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, quickly dropwise add Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was filtered and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and placed in a crucible , Calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores, the pore volume was 0.84cm 3 / ...

Embodiment 2

[0048] Embodiment 2, the preparation of composite material

[0049] (1) Preparation of mesoporous silica nanoparticles

[0050] The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 4859: 2: 8.13 (molar ratio); Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was filtered and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and placed in a crucible , and calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores and a pore volume of 0.89 cm 3 / g, the pore ...

Embodiment 3

[0058] Embodiment 3, the preparation of composite material

[0059] (1) Preparation of mesoporous silica nanoparticles

[0060]The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 9719: 2.55: 8.13 (molar ratio); Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was filtered and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and placed in a crucible , and calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores and a pore volume of 0.81 cm 3 / g, the por...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a composite material for treating dentine hypersensitivity and a preparation method thereof. The method comprises the following steps: (1) mixing mesoporous silica nanometer particles, calcium salt and water to obtain a mixture, drying and then calcining the mixture to obtain calcium-carried mesoporous silica nanometer particle microspheres; (2) mixing the mesoporous silica nanometer particles and a phosphoric acid aqueous solution to obtain a mixture, drying and then calcining the mixture to obtain phosphor-carried mesoporous silica nanometer particle microspheres; and (3) mixing calcium-carried mesoporous silica nanometer particle microspheres, phosphor-carried mesoporous silica nanometer particle microspheres and the water to obtain the composite material for treating dentine hypersensitivity. The composite material provided by the invention is toothpaste-like, can be uniformly smeared on tooth surface with dentine hypersensitivity symptoms by using medical small brush head, and can relatively deeply seal exposed dentinal tubules, so as to isolate external stimulation to the oral and achieve the effect of treatment of dentine hypersensitivity.

Description

technical field [0001] The invention relates to a composite material for treating dentin sensitivity and a preparation method thereof. Background technique [0002] Dentin hypersensitivity disease is mainly caused by irritation caused by exposure of dentine tubules to the oral environment. At present, the ideas for treating dentin sensitivity can be roughly divided into two categories: one is based on the theory of nerves and dentin fiber conduction theory, using toothpaste or varnishes containing potassium compounds such as potassium nitrate and potassium chloride to reduce the The sensitivity of the nerve endings, thereby reducing its response to external stimuli; the second type is based on hydrodynamics, reducing the diameter of the dentinal tubules, closing the opening of the dentinal tubules, and reducing the permeability of the dentine to reduce and avoid dentin. Liquid flow within the essence. The second type of method has been considered to be the fundamental way ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/027
Inventor 蔡强史颖田力丽
Owner TSINGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com