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Traditional Chinese medicinal composition for treating infant eczema

A technology for infant eczema and composition, which is applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems that infants and young children are not suitable for large doses, long-term use in large areas, unsatisfactory curative effect, easy recurrence, etc. Bioavailability, overcoming the large side effects of western medicine, increasing the effect of depot effect

Active Publication Date: 2014-02-26
HUNAN UNIV OF CHINESE MEDICINE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The curative effect of the drugs currently available in the market for the treatment of eczema is not satisfactory, and there are many side effects and adverse reactions
Corticosteroids, although effective quickly, are prone to recurrence after drug withdrawal. For example, topical use of corticosteroids can cause skin thinning, resulting in side effects such as dry skin, atrophy, telangiectasia, and pigmentation. More severe cases may cause Inhibition of the hypothalamus-pituitary-adrenal axis, or growth inhibition, infants and young children should not be used in large doses and large areas for a long time
The safety of topical long-term use of the immunosuppressive drugs tacrolimus and pimecrolimus remains to be determined
There are also some lead and boric acid preparations that have side effects such as poisoning and affecting fertility.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the preparation of oil agent

[0038] (1) Boil the eggs to get the yolk, dry it at 90°C to form egg yolk powder, bake it in an oven at 240°C for 3 hours to obtain egg yolk, and set aside;

[0039] (2) Sophora flavescens medicinal material, add water 9 times the mass of flavescens flavescens and reflux for extraction for 3 hours, collect the extract, concentrate it to 5 times the amount of the raw material (flavor flavescens medicinal material), and then collect the extract to obtain flavescens extract, spare;

[0040] (3) Mix 1.5g of Sophora flavescens extract in the above step (2) with 25g of egg butter in the above step (1), add 2.0g of drug borneol, add 3ml of cosolvent anhydrous ethanol, stir well, bottle, Get the oil.

Embodiment 2

[0041] Embodiment 2: the preparation of ointment

[0042] The preparation of egg yolk and Sophora flavescens extract is the same as in Example 1.

[0043] Heat polyethylene glycol 4000 and polyethylene glycol 400 in a water bath at a ratio of 3:7 to 70°C, remove, add 1.2g of Sophora flavescens extract and 20g of egg oil, add 1.8g of drug borneol, and auxiliary materials, mix , stir evenly, and fill to obtain ointment.

Embodiment 3

[0044] Embodiment 3: the preparation of gel

[0045] The preparation of egg yolk and Sophora flavescens extract is the same as in Example 1.

[0046] Add 3.6g of drug borneol to 40g of egg oil to obtain an oil phase, add 2.4g of Sophora flavescens extract to 2g of swollen Carbomer 940 gel matrix, add 12ml of Tween-80, 8ml of propylene glycol, and stir evenly. It is the water phase, slowly drop the oil phase into the water phase, stir continuously, add a pH regulator to adjust the pH to neutral, stir until it is creamy, and fill it to obtain an oil-in-water gel.

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PUM

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Abstract

The invention discloses a traditional Chinese medicinal composition for treating infant eczema, acute and chronic eczema, and eczematous dermatitis. The traditional Chinese medicinal composition consists of 20-200 parts of egg oil, 0.5-50 parts of borneol and 0.4-5 parts of shrubby sophora extract. The composition, through a process, can be prepared into clinically acceptable dosage forms, such as an oil agent, an ointment, a gel, a soft capsule, a nano preparation and the like, which are concrete in therapeutic effect and convenient to use, carry and store. Both pharmacological study and clinical research show that the composition has functions of clearing away heat and toxic matters, removing dampness and relieving itch, and the composition is used for treating infant eczema, acute and chronic eczema, and eczematous dermatitis caused by interactive damp and hot; and the composition is free from side effect and capable of promoting aged skin renewal, and has a wide market prospect and social and economic values.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating infantile eczema, acute and chronic eczema, and eczematous dermatitis and a preparation method thereof. Background technique [0002] Eczema (eczema) is a superficial dermis and epidermis dermatitis caused by a variety of internal and external factors. The etiology is complicated, and it is generally believed to be related to allergies. The itching is severe, and in the acute stage, papuular herpes is the main symptom; in the chronic stage, lichenification is the main symptom. Infant eczema, also known as eczema and eczema, is a common and frequently-occurring disease in dermatology. It is clinically characterized by skin erythema, papules, blisters, erosion, and exudation accompanied by severe itching. It often recurs and seriously affects the health of infants and young children. and normal development...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61K9/00A61K9/06A61K9/48A61P17/00A61P17/04
Inventor 李顺祥杨永芳严建业王璐
Owner HUNAN UNIV OF CHINESE MEDICINE
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