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Tooth desensitizer as well as preparation method and application thereof

A desensitizer and tooth technology, applied in the field of tooth desensitizers, can solve the problems of inaccessibility of bioactive glass, mutual fusion, no dentin hypersensitivity, etc., and achieve excellent biocompatibility, broad market prospects, prevention and treatment of oral diseases

Inactive Publication Date: 2014-03-19
北京博恩康生物科技有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of silica nanoparticles to the second type of method has serious defects: after the silica nanoparticles are immersed in the dentinal tubules, they cannot be effectively fused with each other and fixed in the dentinal tubules, so that it is easy to dislodge from the dentinal tubules. Prolapse
[0005] However, for the above-mentioned second type of method for treating dentin hypersensitivity, bioactive glass has not entered people's field of vision at all, and this is because: bioactive glass is difficult to prepare as very fine particles, and its particle size is usually in the range of tens of microns , however, the diameter of the dentinal tubules is only 3-4 μm near the medullary cavity, and only 1 μm near the enamel dentin junction, so it is difficult for bioactive glass to enter into the dentinal tubules
Therefore, although bioactive glass has excellent biocompatibility and has a very positive effect on oral treatment, it has not yet been shown that it can treat dentin hypersensitivity through the above-mentioned second type of method

Method used

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  • Tooth desensitizer as well as preparation method and application thereof
  • Tooth desensitizer as well as preparation method and application thereof
  • Tooth desensitizer as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Preparation of mesoporous silica nanoparticles

[0045] The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 8504: 2.55: 8.13 (molar ratio); Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was obtained by suction filtration and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and put into a crucible , calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores, the pore volume was 0.84cm3 / g, and the pore diameter was 3.0 nm;

[0046] The scanni...

Embodiment 2

[0062] (1) Preparation of mesoporous silica nanoparticles

[0063] The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 4859: 2: 8.13 (molar ratio); according to the above formula Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was obtained by suction filtration and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and put into a crucible , calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores, the pore volume was 0.89cm3 / g, and the pore diameter was 3...

Embodiment 3

[0072] (1) Preparation of mesoporous silica nanoparticles

[0073] The ratio of raw materials is cetyltrimethylammonium bromide (CTAB): deionized water: sodium hydroxide: tetraethyl orthosilicate (TEOS) = 1: 9719: 2.55: 8.13 (molar ratio); Mix cetyltrimethylammonium bromide, deionized water and sodium hydroxide, stir the reaction system at 70°C until the temperature is stable, and after the cetyltrimethylammonium bromide is completely dissolved, add n- Ethyl silicate; the reaction system was kept at 70°C for 2 hours. After the reaction, the white solid was obtained by suction filtration and dried in an oven at 50°C for 10 hours; the obtained white powder sample was ground with a mortar and put into a crucible , calcined in a muffle furnace at 550°C for 4 hours to remove the template agent CTAB; the calcined sample was ground again to obtain mesoporous silica nanoparticles with ordered pores, and the pore volume was 0.81 cm 3 / g, the pore diameter is 3.0nm;

[0074] The scann...

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Abstract

The invention relates to a tooth desensitizer as well as a preparation method and application of the tooth desensitizer. The tooth desensitizer is a powdery composite material, comprises mesoporous silica nano-particles and bioactive glass which is injected into pores of the mesoporous silica nano-particles by fusing. The preparation method of the tooth desensitizer comprises the following steps: (1), providing mesoporous silica nano-particles; (2), providing bioactive glass, wherein the bioactive glass is heated until being fused; (3), immersing the mesoporous silica nano-particles into the fused biological active glass, so that the fused biological active glass is injected into the pores of the mesoporous silica nano-particles; and (4), cooling the mesoporous silica nano-particles which are injected with the bioactive glass to form the powdery tooth desensitizer. The powdery tooth desensitizer disclosed by the invention can be mixed with water to form paste, is coated on a tooth surface with a dentin sensitivity symptom by using a brush, and can deeply seal an exposed dentinal tubule, so that external stimuli in an oral cavity is isolated to achieve effect of treating dentin sensitivity.

Description

technical field [0001] The invention relates to a tooth desensitizing agent, its preparation method and application. The tooth desensitizing agent of the present invention can overcome the shortcomings in the prior art, and can deeply seal the exposed dentine tubules, thereby isolating external stimuli in the oral cavity and achieving the effect of treating dentine sensitivity. Background technique [0002] Dentin hypersensitivity disease is mainly caused by irritation caused by exposure of dentine tubules to the oral environment. At present, the ideas for treating dentin sensitivity can be roughly divided into two categories: one is based on the theory of nerves and dentin fiber conduction theory, using toothpaste or varnishes containing potassium compounds such as potassium nitrate and potassium chloride to reduce the The sensitivity of the nerve endings, thereby reducing its response to external stimuli; the second type is based on hydrodynamics, reducing the diameter of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K9/14A61K47/04A61P1/02A61P37/08
Inventor 甘少磊
Owner 北京博恩康生物科技有限公司
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