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Dentin mineralizing agent and method for production thereof

a technology of mineralizing agent and dental enamel, which is applied in the direction of fluorine compound active ingredients, drug compositions, impression caps, etc., can solve the problems of dental enamel exposure due to new dental diseases, wear of teeth, alveolar bone loss, etc., and achieve the effect of reducing caries resistance and treating hyperesthesia

Inactive Publication Date: 2012-02-02
KURARAY NORITAKE DENTAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0028]By the present invention is provided a dentin mineralizing agent by which a dense HAp is formed on a dentin surface and HAp is deposited to a deep portion of a dentinal tubule, so that it can close the dentinal tubule. Thanks to this, a false enamel is formed on a dentin surface to impart caries resistance and treatment of hyperesthesia becomes possible.

Problems solved by technology

In association with this, however, a problem of dentin exposure due to new dental diseases (e.g., wear of teeth, alveolar bone loss caused by periodontal disease, etc.) has arisen.
Exposed dentin is not good in caries resistance because unlike the enamel, tissues constituting the dentin is low in mineral concentration, and the exposed dentin may cause development of, for example, hyperesthesia when a dentinal tubule comes to be open by the action of an acid in an oral cavity.
However, these methods have a problem that a cover is worn by a toothbrush or the like to be broken easily because only a surface or a shallow portion near openings of dentinal tubules are covered.
Moreover, although being a material with high biocompatibility, there has been another problem with it that application of the material makes a plaque adhere, causing inflammation and root caries.

Method used

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  • Dentin mineralizing agent and method for production thereof
  • Dentin mineralizing agent and method for production thereof
  • Dentin mineralizing agent and method for production thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of a dentin mineralizing agent

1) Preparation of tetracalcium phosphate particles (A)

[0069]The tetracalcium phosphate particles (A1) (average particle diameter=23.1 μm) to be used in this example were prepared by pulverizing crude tetracalcium phosphate prepared by the following procedures. A cake-like equimolar mixture was obtained by adding commercially available dicalcium phosphate anhydrous particles (Product No. 1430, made by J. T. Baker Chemical Co., NJ) and calcium carbonate (Product No. 1288, made by J. T. Baker Chemical Co., NJ) in equimolar amount to water, followed by stirring for one hour, filtering and drying. The cake-like equimolar mixture was heated in an electric furnace (FUS732PB, manufactured by ADVANTEC MFS, INC.) at 1500° C. for 24 hours, and then a tetracalcium phosphate lump was prepared by cooling the mixture to room temperature in a desiccator. The resulting lump was further ground roughly in a mortar and then screened to remove fine powders and t...

example 2

[0083]A dentin mineralizing agent was prepared in the same manner as in Example 1 except for failing to use the dicalcium phosphate anhydrous particles (C1) and preparing the rest by using purified water in Example 1, and then measurement of an alkali metal ion concentration, morphological evaluation, and dentin penetration inhibition ratio evaluation were performed. The composition of the dentin mineralizing agent used is summarized in Table 1, and the evaluation results obtained are summarized in Table 4.

example 3

[0084]A dentin mineralizing agent was prepared in the same manner as in Example 1 except for preparing it by adding the disodium hydrogen phosphate (B) particles to the paste in liquid form instead of by adding to the powder agent in Example 1, and then measurement of an alkali metal ion concentration, morphological evaluation, and dentin penetration inhibition ratio evaluation were performed. The composition of the dentin mineralizing agent used is summarized in Table 1, and the evaluation results obtained are summarized in Table 4.

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Abstract

A dentin mineralizing agent comprising tetracalcium phosphate particles (A) and an alkali metal salt of phosphoric acid (B), wherein the dentin mineralizing agent contains the tetracalcium phosphate particles (A) in an amount of 1 to 80 parts by weight relative to 100 parts by weight of the whole amount of the dentin mineralizing agent, and the blended amount of the alkali metal salt of phosphoric acid (B) relative to 100 parts by weight of the tetracalcium phosphate particles (A) is 1 to 100 parts by weight. Thus is provided a dentin mineralizing agent by which a dense HAp is formed on a dentin surface and HAp is deposited to a deep portion of a dentinal tubule, so that it can close the dentinal tubule.

Description

TECHNICAL FIELD[0001]The present invention relates to dentin mineralizing agents for mineralizing a dentin surface and a deep portion of a dentinal tubule.BACKGROUND ART[0002]Along with a so-called “8020 campaign” (improvement in dental health, preservation of dentin (MI: Minimal Intervention)) to try to keep 20 or more own teeth even when being 80 years old, the ratio at which many teeth remain in aged persons have rapidly increased. In association with this, however, a problem of dentin exposure due to new dental diseases (e.g., wear of teeth, alveolar bone loss caused by periodontal disease, etc.) has arisen. Exposed dentin is not good in caries resistance because unlike the enamel, tissues constituting the dentin is low in mineral concentration, and the exposed dentin may cause development of, for example, hyperesthesia when a dentinal tubule comes to be open by the action of an acid in an oral cavity. As a method of improving this, there have been known a method of coating with...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/24A61Q11/00A61K8/02A61K6/838
CPCA61K6/0017A61K6/033A61K8/0241A61K8/24A61K33/16A61K33/42A61K45/06A61Q11/00A61K2800/412A61K2300/00A61K6/20A61K6/838A61P1/02A61P25/02
Inventor HASHIMOTO, TADASHISUGIURA, MARIKOISHIHARA, SHUMEIKAWASHIMA, MITSUNOBUOKADA, KOICHI
Owner KURARAY NORITAKE DENTAL
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