108 results about "Uropathy" patented technology

An external stimulator adapted to be inductively coupled with an implanted lead-receiver is designed to deliver neuromodulation therapy for disorders including depression, migraine, partial complex epilepsy, generalized epilepsy, involuntary movement disorders, dementia, obsessive compulsive disorders, urinary incontinence, neurogenic / psychogenic pain and bladder control. The external stimulator containing limited number of predetermined programs packaged into the stimulator, giving the patient or caretaker a way to adjust the therapy within confined limits, or turn the device off. The pre-packaged programs contain unique combination of pulse amplitude, pulse width, frequency of stimulation, and on-off time. The programs are capable of being modified with a programming station connected to the pulse generator with a RS232-C serial connection.

An external pulse generator comprising a primary coil and adapted to inductively couple to an implanted receiving means, is designed to deliver neuromodulation therapy for disorders comprising obesity, eating disorders, anxiety and the like. The external pulse generator contains limited number of predetermined programs. These programs provide the patient or caretaker a means to adjust the therapy within confined limits, or turn the device off. The predetermined programs contain unique combination of pulse amplitude, pulse width, frequency of stimulation, and on-off time. In another mode of operation, the parameters can be individually adjusted and the stimulation therapy program can be “customized” for the patient, and stored in the memory. The programs are capable of being modified with a programming station connected to the pulse generator with a RS232-C serial connection. Additionally, the external pulse generator has two-way wireless capabilities, whereby enabling the physicians to remotely control the therapy programs of their patients using wireless internet. Moreover, the external pulse generator has proximity sensing and feedback regulation component to provide a constant therapy in accordance with the predetermined programs.

A minimally invasive surgical instrument for placing an implantable article about a tubular tissue structure is disclosed. The surgical instrument is particularly useful for treating urological disorders such as incontinence. Surgical methods using the novel instrument are also described.

The invention discloses a probe set for detecting whole exons of extended genetic diseases. The probe set for detecting the whole exons of the extended genetic diseases comprises a standard whole exonprobe set, a whole genome copy number variation probe, and a mitochondrial loop full-length probe, and the genetic diseases comprise 6161 genetic diseases; the standard whole exon probe set can detect the genetic diseases caused by whole exon mutation, the genetic diseases comprise nervous system diseases, metabolic system diseases, endocrine system diseases, digestive system diseases, skeletal system diseases, urinary system diseases, immune system diseases, cardiovascular system diseases, blood system diseases, integument system diseases, ophthalmic system diseases, ear system diseases, respiratory system diseases, and genital system diseases; and the density of the mitochondrial probe is 6X; test samples comprise blood, fresh tissue, FFPE samples, and saliva. The invention discloses using method and kit and application of the probe set for detecting the whole exons of the extended genetic diseases.

A method and system for providing pulsed electrical stimulation to sacral nerves and / or its branches, to provide therapy for urinary / fecal incontinence and other urological disorders. The stimulation system comprising implanted and external components. The pulsed electrical stimulation may be provided using a system which is one from a group comprising: a) an implanted stimulus-receiver with an external stimulator; b) an implanted stimulus-receiver comprising a high value capacitor for storing charge, used in conjunction with an external stimulator; c) a programmer-less implantable pulse generator (IPG) which is operable with an external magnet; d) a programmable implantable pulse generator; e) a combination implantable device comprising both a stimulus-receiver and a programmable IPG; and f) an implantable pulse generator (IPG) comprising a rechargeable battery. In one embodiment, the external components such as the programmer or external stimulator may comprise telemetry means for interrogation or programming of the implanted device from a remote location, over a wide area network.

A method and system for neuromodulation therapy for urinary incontinence and urological disorders comprises an implantable lead stimulus-receiver, and an external stimulator-transmitter having a power source, controlling circuitry, and predetermined programs. The stimulator-transmitter further includes a primary coil which inductively transfers electrical signals to the lead-receiver, which is also in electric contact with the sacral nerves. The external stimulator-transmitter emits electrical pulses to stimulate the sacral plexus according to a predetermined program. In one mode of operation, the operator may program one of the predetermined programs, in another mode, the electrical parameters may be “custom” programmed for the patient, and stored in the memory.

The present invention relates to implantable or insertable medical devices that treat uterine and urological conditions that cause chronic pelvic pain and other symptoms. In another aspect, the present invention relates to methods of manufacturing such implantable or insertable medical devices.

The disclosure describes a wireless urodynamic monitoring system with an automated voiding diary feature. The system senses and records urodynamic information in response to a user command or in response to detection of the onset of a voiding event. The urodynamic information obtained over a series of voiding events forms an automated voiding diary that is useful in diagnosis of urological disorders. An implantable monitor obtains the urodynamic information and either records the information locally or transmits the information to an external controller via a wireless telemetry link. In some embodiments, the external controller may include a loop recorder for recording urodynamic information obtained by the implantable monitor over an extended period of time.

A method and system for providing electrical pulses for neuromodulating sacral nerves of a patient utilizing an implantable stimulator. The implantable stimulator comprising a pulse generator module and a stimulus receiver module for coupling with an external stimulator. Control circuitry ensures selective operation of one pulse generator module. The external stimulator comprises a telemetry module for remotely activating (or de-activating) programs over the internet, to arrive at the optimal program for each patient. Once the optimal “dose” is titrated using the external stimulator, the implanted pulse generator can then be programmed to such parameters. The external stimulator in conjunction with the implanted stimulus receiver can override the implanted pulse generator, to provide extra dose of therapy or to conserve the implanted battery. The external stimulator is also networked to other computers. The external programmer may also comprise a global positioning system (GPS) module for determining patient location.

This invention provides a combination of microRNAs for evaluating the physiological and / or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum / plasma of a subject; and a method for evaluating the physiological and / or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum / plasma of a subject; and a kit for evaluating the physiological and / or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum / plasma of a subject; and a biochip for evaluating the physiological and / or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum / plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors; various acute / chronic infectious diseases, e.g. viral diseases such as viral influenza, viral hepatitis, AIDS, SARS, bacterial diseases such as tuberculosis, bacterial pneumonia, and other acute / chronic infectious diseases caused by various pathogenic microorganisms; other acute / chronic diseases such as diseases of respiratory system, diseases of immune system, diseases of blood and hematopoietic system, diseases of circulatory system such as cardio-cerebrovascular diseases, metabolic diseases of endocrine system, diseases of digestive system, diseases of nervous system, diseases of urinary system, diseases of reproductive system and diseases of locomotor system, prediction of complications occurrence and malignant diseases relapse, evaluation of therapeutic effects, screening of pharmaceutical active ingredients, assessment of drug efficacy as well as forensic authentication and prohibited drug inspection and the like, possessing a number of advantages such as extensive detection spectrum, high sensitivity, low cost, convenience for sampling, ease for sample preservation, etc. The said method can be widely used in work related to general survey of diseases and so on, improve the low-specificity and low-sensitivity caused by individual differences which single markers are difficult to overcome, significantly increasing the clinical detection rate of diseases, all of which make it become an effective means for diagnosing diseases in an early phase.

The invention relates to compounds of the general formula (I): whereinAr is optionally substituted aryl or heteroaryl;A is (i) —O—, —S—, —SO2—, —NH—, (ii) a C1-4-alkyl- or C1-6-acyl-substituted nitrogen atom or (iii) a C1-8-alkylene chain or a heteroalkylene chain having 2 to 8 chain atoms, which optionally contains at least one unsaturation, and which may be substituted and / or contain a bridge to form a saturated or partially or fully unsaturated ring having 3-8 ring members;B is —C(R4)(R5)—, —OC(R4)(R5)—, —N(R6)C(R4)(R5)—, —N(R6)—, —O—, —S— or —SO2—;R is optionally substituted C3-8-cycloalkyl, aryl or heteroaryl;R1 is (i) a saturated or unsaturated azacyclic or aminoazacyclic ring, or a saturated diazacyclic or aminodiazacyclic ring, which has 4 to 7 ring members, or a saturated aminoazabicyclic, azabicyclic or diazabicyclic ring which has 7 to 10 ring members, which rings optionally are substituted in one or more positions, or a group —[C(R4)(R5)]xN(R2a)(R3a)];R2a, R3a, R4, R5, R6 and x are as defined in the claims, and n is 0 or 1; and pharmaceutically acceptable salts, hydrates and prodrug forms thereof.The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from a serotonin-related disorder, such as eating disorders, especially obesity, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctions, and urinary disorders. The invention also relates to such use as well as to pharmaceutical compositions comprising a compound of formula (I).

The invention relates to a medical gasification resectoscope for inspecting and electric-cutting in urinary system. The opened operation of the traditional urinary system has the defects of large cut and damnifies, a plurality of blooding during operation and stimulated symptoms, long pathogenesis and enormous pains after the operation. The invention provides the gasification resectoscope, which comprises a main body, a sheath, an endotheca capable for inserting into the sheath and an inserting piece capable of inserting into the endotheca. The invention has the advantages of unnecessary of operating, small pain, light blooding, quick for recovery and reliable effects, which enables the operation safer, more precious and thorough, thus largely deducing the operation time, releasing the pain of the patients and shortening the curing time; besides, the invention is capable of being sterilized with high temperature and pressure and features uneasy for rusting; in addition, the physiological saline and excision enter and exit through different cannuls, thus enabling the cutting scope easy for control and has simple operation and clear version.

Some implementations provide a method for treating urological disorders in a patient, the method including: placing an introducer into a patient's body through an incision site on the patient's body, the patient suffering from an urological disorder; placing an implantable wireless device into an inner lumen of the introducer, the implantable wireless device suitable to fit into the inner lumen and configured to receive electromagnetic energy non-inductively from a source located outside the patient's body; through the inner lumen of the introducer, positioning the implantable wireless device adjacent to or near one or more excitable tissue in the patient, the one or more excitable tissue regulating a nerve activity associated with the urological disorder; and causing neural modulation of the one or more excitable tissue through one or more electrodes on the implantable wireless device.

The present invention relates to phenyl or heteroaryl amino alkane derivatives of formula (I) in which the groups Q1-Q4, Ar, and R1-R7 are as defined in the specification and claims. These materials are useful as active ingredients of pharmaceutical preparations. The phenyl or heteroaryl amino alkanes of the present invention have IP receptor antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with IP receptor antagonistic activity. Such diseases include urological diseases or disorders as follows: bladder outlet obstruction, overactive bladder, urinary incontinence, detrusor hyper-reflexia, detrusor instability, reduced bladder capacity, frequency of micturition, urge incontinence, stress incontinence, bladder hyperreactivity, benighn prostatic hypertrophy (BPH), prostatitis, urinary frequency, nocturia, urinary urgency, pelvic hypersensitivity, urethritis, pelvic pain syndrome, prostatodynia, cystitis, or idiophatic bladder hypersensitivity. The compounds of the present invention are also useful for treatment of pain including, but not limited to inflammatory pain, neuropathic pain, acute pain, chronic pain, dental pain, premenstrual pain, visceral pain, headaches, and the like; hypotension; hemophilia and hemorrhage; and inflammation, since these diseases also are alleviated by treatment with an IP receptor antagonist. The application claims the compounds, pharmaceutical compositions containing them, and methods of treatment using them.

The present invention related to methods for treating neurological-urological conditions, including urinary retention. This is accomplished by administration of a botulinum toxin into the lower urinary tract of a patient with urinary retention, including the bladder or urinary sphincter and the bladder wall.

A minimally invasive surgical instrument for placing an implantable article about a tubular tissue structure is disclosed. The surgical instrument is particularly useful for treating urological disorders such as incontinence. Surgical methods using the novel instrument are also described.

The invention relates to an aryl [a] indole [2,3-g] quinolizine compound as well as a preparation method, a pharmaceutical composition and application thereof, and particularly relates to a aryl [a] indole [2,3-g] quinolizine compound with a novel structure as shown in a general formula (I) and a derivative, a preparation method and a pharmaceutical composition thereof and application of the aryl [a] indole [2,3-g] quinolizine compound in preparation of a drug for treating diseases related to alpha 1-adrenoreceptor and urinary system diseases, such as benign prostatic hyperplasia, uroschesis and bladder outlet obstruction, especially.

The present invention relates to methods for treating neurological-urological conditions. This is accomplished by administration of at least one neurotoxin.

The present invention relates to a method, preferable an oral method, for treating urinary disorders, such as unstable or overactive bladder, while minimizing the occurrences of dry mouth, dyspepsia and reduced stream of tears. The methods of the present invention comprise orally administering to a mammal, preferably a human, a pharmaceutically effective dose of an antimuscarinic agent, such as tolterodine, when needed, whereby a symptomatic relief of urgency and / or frequency is achieved.

Disclosed is a therapeutic agent for difficulty in urination associated with overactive bladder, frequent urination, urinary incontinence or prostatomegaly or urinary calculus, which comprises a compound having a PDE9-inhibiting activity as an active ingredient.

Disclosed is a treating agent of overactive bladder syndrome, pollakiuria, urinary incontinence, dysuria in benign prostatic hyperplasia or urolithiasis, which comprises a compound having PDE9-inhibiting activity as the active ingredient.

This invention provides a combination of microRNAs for evaluating the physiological and / or pathological condition of a subject, wherein the combination comprises all detectable microRNAs stably existing in the serum / plasma of a subject; and a method for evaluating the physiological and / or pathological condition of a subject, wherein the method includes determining all detectable microRNAs stably existing in the serum / plasma of a subject; and a kit for evaluating the physiological and / or pathological condition of a subject, wherein the kit contains the tools for determining all detectable microRNAs that stably existing in the serum / plasma of a subject; and a biochip for evaluating the physiological and / or pathological condition of a subject, wherein the biochip contains the components for determining all detectable microRNAs stably existing in the serum / plasma of a subject. The aforementioned combination, method, kit and biochip can be used for diagnosis as well as differentially diagnosis of diseases including various tumors; various acute / chronic infectious diseases, e.g. viral diseases such as viral influenza, viral hepatitis, AIDS, SARS, bacterial diseases such as tuberculosis, bacterial pneumonia, and other acute / chronic infectious diseases caused by various pathogenic microorganisms; other acute / chronic diseases such as diseases of respiratory system, diseases of immune system, diseases of blood and hematopoietic system, diseases of circulatory system such as cardio-cerebrovascular diseases, metabolic diseases of endocrine system, diseases of digestive system, diseases of nervous system, diseases of urinary system, diseases of reproductive system and diseases of locomotor system, prediction of complications occurrence and malignant diseases relapse, evaluation of therapeutic effects, screening of pharmaceutical active ingredients, assessment of drug efficacy as well as forensic authentication and prohibited drug inspection and the like, possessing a number of advantages such as extensive detection spectrum, high sensitivity, low cost, convenience for sampling, ease for sample preservation, etc. The said method can be widely used in work related to general survey of diseases and so on, improve the low-specificity and low-sensitivity caused by individual differences which single markers are difficult to overcome, significantly increasing the clinical detection rate of diseases, all of which make it become an effective means for diagnosing diseases in an early phase.

The invention discloses a rapid auto-navigation magnetic resonance hydrography imaging method and device. Clinical application models of the invention include a breath-holding navigation mode and a free breath navigation mode. Adult patients with good breath control ability can adopt the breath-holding navigation mode, and infant patients with poor breath control ability can adopt the free breath navigation mode. The method and the device can obviously improve the acquisition efficiency, the control accuracy and the signal to noise ratio of magnetic resonance signals, can avoid an interference effect between an imaging sequence and a navigation wave sequence, and can enhance respiratory movement artifact inhibition effect; and the method and the device is simple in clinic operation, can obviously decrease coordination difficulties of patients, is conductive to clinical application of the magnetic resonance hydrography imaging technique, and can achieve unique diagnosis determining value in clinical diagnosis of a biliary system and a urinary system.

This invention relates to derivatives of substituted azabicyclo hexanes. The compound of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

The invention relates to a traditional Chinese medicine for treating chronic prostatitis, belonging to the field of traditional Chinese medicines for treating urinary system diseases. The traditional Chinese medicine is prepared from dwarf lilyturf root tuber, Chinese angelica, lucid ganoderma, rehmannia root, radix pseudo-ginseng, Polygonum aviculare, asiatic plantain seed and other raw materials. The traditional Chinese medicine has the effects of supporting health energy, invigorating qi, nourishing blood, promoting blood circulation, dispersing blood stasis and inducing diuresis for treating stranguria, and has the advantages of distinct effect, definite drug effect and quick action.

The invention provides a traditional Chinese medicine processed common motherwort herb, a processing method and applications thereof. The processed common motherwort herb is processed through the following method: a) preparing a ginger juice: slicing fresh ginger, and adding the slices to boiled clear water to carry out water boiling to obtain a ginger juice; 2) preparing a processing solution: mixing the ginger juice obtained in the step 1), rice vinegar, yellow wine and salt to prepare a processing solution; 3) moistening: adding the processing solution obtained in the step 2) to a common motherwort herb dry herb, uniformly stirring, and moistening until the processing solution is completely absorbed to obtain moistened common motherwort herb; 4) steaming: steaming the moistened common motherwort herb obtained in the step 3) to obtain steamed common motherwort herb; and 5) drying: drying the steamed common motherwort herb obtained in the step 4). The invention further provides applications of the processed common motherwort herb in preparation of drugs for treatments of gynecologic diseases such as menoxenia, dysmenorrheal, amenorrhea, lochiorrhea and vaginitis, urinary system diseases such as acute nephritis edema, edema oliguresis, and fecal and urine stoppage, and / or other related diseases such as internal and external blood stasis syndromes.

The invention provides a human AHR which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation, respiratory diseases, urological diseases and gastroenterological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation, respiratory diseases, urological diseases and gastroenterological diseases. The invention also features compounds which bind to and / or activate or inhibit the activity of AHR as well as pharmaceutical compositions comprising such compounds.

The invention relates to a medicinal and dietary composition for reducing fever, promoting diuresis and its preparation method, wherein the medicament is prepared mainly from Chinese herbs including pyrrosia lingua farw, plantain seeds, Chinese pink herb, talcum, seed of cowherb and malva seed.