Device and method for detecting human body microcirculation by means of orthogonal polarization spectral imaging

Abstract

The invention discloses a device and method for detecting human body microcirculation by means of orthogonal polarization spectral imaging. The device comprises a first point light source, a first 805-nm narrow-band interference filter, a first focusing lens, a second point light source, a first 548-nm narrow-band interference filter, a second focusing lens, a light composition lens, an isolation lens, a polarization splitting prism, a microscope objective, a polarization analyzer, a beam splitter, a second 548-nm narrow-band interference filter, a second 805-nm narrow-band interference filter, a first CCD camera, a second CCD camera and a computer. Parallel light with the wavelength being 805 nm and 548 nm is irradiated on the light composition lens, perpendicularly reflected by the isolation lens and the polarization splitting prism, and focused on detected tissue on a finger rest through the microscope objective, light reflected from the interior of the detected tissue passes through the polarization analyzer and then is irradiated on the beam splitter, the first and second CCD cameras shoot images which are processed by the computer, and then clear microvessel images can be obtained. The influence of movement of a target object on the detected tissue on imaging can be eliminated, and the imaging quality can be improved.

Description

technical field [0001] The invention belongs to the application of optical imaging technology in the field of medical diagnosis, and in particular relates to a device and method for detecting human microcirculation by using orthogonal polarization spectrum imaging. Background technique [0002] The human microcirculatory system refers to the blood circulation with a diameter of less than 100 μm between arterioles and veins in the vascular network, which together with microlymphatic vessels constitute the functional unit of microcirculation. Through blood circulation, blood and tissue cells exchange oxygen, nutrients, hormones and metabolites. Under normal circumstances, the microcirculatory blood flow adapts to the metabolism level of human tissues and organs, so that each organ in the human body can realize its normal physiological functions. The functional status of microcirculation has important physiological, pathological, pharmacological and clinical significance. Man...

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Problems solved by technology

This method is cumbersome for the selective processing of two beams of reflected polarized light, and the image definition is not high

[0007] Xu Qian, Lei Junfeng, and Zeng Libo published the article "Orthogonal Polarization Spectral Imaging for Microcirculation Observation in Vivo" (Spectroscopy and Spectral Analysis, 2010(07): 1886-1889), which constructed a small, concise The in vivo microcirculation multispectral imaging system, which applies orthogonal polarization spectral imaging OPSI and crystal tunable filter LCTF to in vivo microcirculation multispectral imaging, can quickly realize wavelength tuning in the visible-near-infrared band, but this The system is a time-sharing tuning system. The movement of the target object on the measured tissue (such as blood flow) will affect the imaging, and it cannot capture the orthogonal polarization image at the same time in real time.

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