124 results about "Antidiarrheals" patented technology

The sulfonamide or carboamide derivatives of the formula (I) and a pharmaceutical composition which comprise them as an active ingredient:(wherein A ring, B ring is carbocyclic ring, heterocyclic ring; Z1 is -COR1, -CH=CH-COR1 etc.; Z2 is H, alkyl etc.; Z3 is single bond, alkylene; Z4 is SO2, CO; Z5 is alkyl, phenyl, heterocyclic ring etc.; R2 is CONR8, O, S, NZ6, Z7-alkylene, alkylene etc.; R3 is H, alkyl, halogen, CF3 etc.; R4 is H, (substituted) alkyl etc.; n, t is 1-4).The compounds of the formula (I) can bind to receptors of PGE2 and show antagonistic activity against the action thereof or agonistic activity. Therefore, they are considered to be useful as medicine for inhibition of uterine contraction, analgesics, antidiarrheals, sleep inducers, medicine for increase of vesical capacity or medicine for uterine contraction, cathartic, suppression of gastric acid secretion, antihypertensive or diuretic agents.

The invention discloses a traditional Chinese medicine preparation for treating chronic colitis and a preparation method thereof. The traditional Chinese medicine preparation are prepared from the following medicinal raw materials in parts by weight: 10-20 parts of pasqueflower, 10-20 parts of yam, 10-20 parts of bletilla, 10-20 parts of baikal skullcap root, 10-20 parts of radix sophorae flavescentis, 10-20 parts of nutmeg, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of tuckahoe, 10-20 parts of garden burnet, 10-20 parts of bulbus allii macrostemi, 10-20 parts of pericarpium arecae, 10-20 parts of coptis, 10-20 parts of dried old orange peel, 10-20 parts of alum, 10-20 parts of bark of Chinese ash, 10-20 parts of focal divina commedia, 10-20 parts of fructus schizandrae, 10-20 parts of ginger and 10-20 parts of granatum. The traditional Chinese medicine preparation discloses by the invention has the functions of antidiarrheal and diminishing inflammation, resolving tetany and relieving pain, improving local blood circulation and metabolism, reinforcing the intestinal immune function and prompting the ulcer recovery. The traditional Chinese medicine preparation discloses by the invention is simple and convenient in preparation process, has small toxic and side effects, is conveniently applied, and is low in cost and easy to prepare. Furthermore, the traditional Chinese medicine preparation directly reaches the focus, so that the healing time is short, and the disease does not recur after being healed.

The invention discloses traditional Chinese medicine antidiarrheal powder for treating ulcerative colitis, mainly solving the problem of low curative effect and side effect existing in present medicines for treating ulcerative colitis. The antidiarrheal powder disclosed herein has an effective rate for treating ulcerative colitis of more than 95%, and a cure rate of 80%, and has no toxic or side effect. The antidiarrheal powder disclosed herein is prepared by grinding 15 parts of Chinese yam rhizome, 6 parts of Myrobalan pulp and 6 parts of pomegranate rind together into fine powder. The application of the antidiarrheal powder disclosed herein is characterized by applying 4.5g three times daily after dissolved in boiled water on an empty stomach.

The invention relates to an anti-diarrhea medicine, in particular to an anti-diarrhea oral liquid containing traditional Chinese medicines of rhizoma atractylodis, tuckahoe and the like and a preparation method thereof, belonging to the technical field of medicine and health. The anti-diarrhea oral liquid comprises the following ingredients by weight proportion: 30-90g of rhizoma atractylodis, 120-180g of tuckahoe, 70-130g of honeysuckle, 70-130g of bupleurum, 90-150g of kudzuvine root, 70-130g of baikal skullcap root, 120-180g of vervain, 120-180g of cherokee rose, 30-90g of elecampane, 10-60g of areca and 10-60g of licorice. The oral liquid has the main effects of heat clearing, moisture eliminating, spleen invigorating and diarrheic stopping, and can treat rotavirus enteritis of children. The clinical treatment effect is obvious, the treatment is safe without toxic and side effects, the recovery rate is 60.47%, the effective rate is 93.69%, and the treatment effect of the anti-diarrhea oral liquid on rotavirus enteritis is especially obvious.

The invention relates to a traditional Chinese medicine formula of antidiarrheal for children, which comprises the following active pharmaceutical ingredients by weight: 3 to 6g of charred atractylodes rhizome, 3 to 6g of charred white atractylodes rhizome, 4 to 6g of lotus seed, 8 to 10g of stir-fried hyacinth beans, 8 to 10g of Chinese yam, 1 to 3g of ricepaperplant pith, 5 to 6g of poria cocos, 3 to 6g of semen plantaginis, 5 to 6g of medicine terminalia fruit, 3 to 4g of simmered nutmeg, 3 to 5g of ginger mix-fried cortex magnoliae officinalis, 3 to 4g of endothelium corneum gigeriae galli, 2 to 3g of charred coptis chinensis and 1 to 2g of liquorice. The traditional Chinese medicine formula disclosed by the invention has the efficacy of tonifying the spleen, inducing diuresis, clearing heat, relieving distension and curing diarrhea; the traditional Chinese medicine formula is suitable for treating children suffering from diarrhea for a long time, and has the advantages of good curative effect, short period of treatment, low cost and no toxic or side effect.

An object of the present invention is to provide a pharmaceutical agent or composition useful as a muscle-strengthening drug, an anti-inflammatory drug, an antiasthmatic, an antidiarrheal, an antidepressant, or a drug for the treatment of secondary diseases following cerebral infarction, motor paralysis, diminution of vision, hepatitis, inflammatory intestinal syndrome, functional enteropathy, functional cardiopathy, functional hepatopathy, functional nephropathy, dementia, climacteric symptoms, senile dementia and/or Alzheimer disease, and a dermatological agent or composition suitable for skin applications, which can treat or prevent muscle weakening and inflammation, in particular arthritis, by its muscle-strengthening and/or anti-inflammatory actions, said agent or composition comprising isoflavone and/or isoflavone glycoside in combination with a pungent substance, a bitter substance or a sour substance, and cholic acid, and/or scymnol and/or a scymnol ester. The present invention relates to an agent or composition usuful as a muscle-strengthening drug, an anti-inflammatory drug, an antiasthmatic, an antidiarrheal, an antidepressant, or a drug for the treatment of secondary diseases following cerebral infarction, motor paralysis, diminution of vision, hepatitis, inflammatory intestinal syndrome, functional enteropathy, functional cardiopathy, functional hepatopathy, functional nephropathy, dementia, climacteric symptoms, senile dementia and/or Alzheimer disease, and/or an agent or composition to be applied to the skin, said agent or composition comprising isoflavone and/or isoflavone glycoside in combination with a pungent substance, a bitter substance or a sour substance, and cholic acid, and/or scymnol and/or a scymnol ester.

The invention relates to a pharmaceutical composition for treating infantile splenic asthenia and moist heat diarrhea (spleen invigorating and diarrhea arresting pharmaceutical composition) and preparation method thereof. The pharmaceutical composition is prepared from the raw materials including codonopsis pilosula, lotus seed, white hyacinth bean, rhizoma coptidis, Baical Skullcap Root, honeysuckle, massa medicata fermentata, hawthorn, plantain seed and dried ginger. The preparation method comprises: adding water into and then boiling the codonopsis pilosula and other nine raw materials; combining the water solutions, filtering the combined water solution, subjecting a filtrate to vacuum concentration to 144 to 904ml, cooling the filtrate, adding ethanol having the same volume as the filtrate into the filtrate, mixing the mixed solution uniformly, standing the mixed solution for 12 to 24 hours and filtering the mixed solution; after recovery of ethanol, condensing the filtrate and obtaining a clear paste with a specific density of 1.15 to 1.25 (50 to 60 DEG C); adding medicinal accessories into the clear paste, mixing the mixture uniformly and making the mixture into grains; and drying the grains to obtain the pharmaceutical composition. The mixing ratio of crude drugs of the pharmaceutical composition is obtained through scientific selection. The pharmaceutical composition has efficacies of reducing fever and dehumidification, and invigorating spleen and arresting diarrhea and is used for treating infantile splenic asthenia and moist heat diarrhea and addresses both the symptoms and root cause. The spleen invigorating and diarrhea arresting drug prepared by the method improves the utilization rate of active ingredients, can be absorbed completely by human bodies, improves drug effect and is optimal for clinic application.

The invention provides an infantile spleen-tonifying and antidiarrheal medicine, belongs to the technical field of diarrhea type traditional Chinese medicine preparations, and aims to solve the problem of lack of effectivedrugs and treatments against infantile diarrhea caused by various reasons. The infantile spleen-tonifying and antidiarrheal medicine is proportionally prepared by fried rhizoma atractylodis macrocephalae, fried Chinese yam, poria cocos, endothelium corneum gigeriae galli, semen plantaginis, myristica fragrans, fructus amomi, cassia twig, cinnamon and liguorice. A traditional Chinese medicine formula prepared above is rigorous, reasonably uses fewer but better ingredients and achieves good results in treatment of the infantile diarrhea. Meanwhile, the infantile spleen-tonifying and antidiarrheal medicine is mild in properties, pungent and sweet in taste and easy for infants to accept and take, and the infantile warm-taken decoction can be filled into a feeding-bottle to have the infant fed. The infantile spleen-tonifying and antidiarrheal medicine used for the treatment of infantile dyspeptic diarrhea is good in curative effect, quickly effective, good in taste and easy to feed, and more convenient and popular when prepared into granules.

The invention relates to a traditional Chinese medicine composition for treating fowl typhoid and a preparation method thereof. The traditional Chinese medicine composition comprises the following ingredients, by weight, 20-40 parts of the root of Chinese pulsatilla, 10-20 parts of phellodendron, 10-20 parts of Scutellaria baicalensis, 10-20 parts of radix platycodi, 5-15 parts of honeysuckle flower, 10-20 parts of humifuse euphorbia herb and 10-20 parts of licorice. The traditional Chinese medicine composition has antimicrobial, anti-inflammation, heat-clearing and antidiarrheal effects, has little toxic and side effect, has no drug residue, is not easy to generate drug resistance, is convenient to use, is easy to absorb, has high bioavailability, meets requirements of safe veterinary drug and animal-derived food safety guarantee, and is an ideal traditional Chinese medicine composition for treating fowl typhoid.

The present invention relates to a Chinese patent medicine for cuirng chronic diarrhea-bowels-freeing antidiarrheal preparation. It is formed from two portions of bowels-freeing medicine and antidiarrheal medicine which are made up by respectively using the Chinese medicinal materials of croton frost, raw rhubarb and stir-fried radish seed and ledebouriella root, coptis root, roasted nutmeg, codonopsis root and stir-fried ovate atractylodes. Its effective rate is 100% and its cure rate is 83%.

The invention discloses a pediatric diarrhea treatment device which comprises the components of a pediatric diarrhea treatment bedplate body, a back supporting device, a back foldable device, a front belly antidiarrheal device, a power supply box, a lower elevating device and an inner control module; wherein the back supporting device, the back foldable device, the front belly antidiarrheal device, the power supply box, the lower elevating device and the inner control module are connected with the pediatric diarrhea treatment bedplate body. The back supporting device is provided with a back supporting pad. The left side of the back supporting pad is provided with an image displaying supporting rod placement trough. The image displaying supporting rod placement trough is internally provided with an image displaying supporting rod. The image displaying supporting rod is provided with an image displaying panel. The front side of the image displaying panel is provided with a data display screen. One side of the data display screen is provided with a music player. The right side of the back supporting pad is provided with a magnetic treatment headrest fixing trough which is internally provided with a supporting headrest. The pediatric diarrhea treatment device has the following advantages in pediatric diarrhea treatment: effective time and force consumption reduction, scientific and convenient operation, high safety, high effectiveness, high effectiveness, complete function, and effective operation difficulty reduction of medical personnel. The pediatric diarrhea treatment device is provided with the music player and reduces fear of a child to a hospital and a doctor, thereby realizing relatively good treatment effect.

The present invention relates to a Chinese medicine preparation-Renshen Zhixieling for curing diarrhea diseases, specially for curing diarrhea due to hypofunction of the spleen, excessive dampness causing diarrhea, diarrhea due to cold-dampness and chronic and habitual diarrhea, etc. with obvious therapeutic effect. Said Chinese medicine preparation is made up by using 9 Chinese medicinal materials of alisma tuber, talcum, coix seed, Chinese yam, euryal seed and others through the conventional preparation process.

The invention discloses an infant broad spectrum antidiarrheal granule and a preparation method thereof. The preparation method comprises the following steps: using water which is 6 to 10 times of the weight of crude medicines to soak patchouli, Magnolia officinalis, Atractylodes chinensis and dried orange peels for 0.5 to 1.5 hours first, performing distillation for 6 to 10 hours, and collecting volatile oil; collecting medicine juice and medicine dregs for standby; adding water which is 6 to 10 times of the weight of crude medicines into Poria coccus, Alisma orientale, Herba Plantaginis and maticated leaven for decoction; mixing a decocted fluid and the medicine juice, concentrating the mixture to obtain an extract, cooling the extract, adding ethanol for standing and filtration, reclaiming the ethanol, performing concentration until an extract is obtained, adding water for dissolution, shaking the mixture evenly, performing cold preservation and filtration on the mixture, performing concentration until a clear paste is obtained, and drying and crushing the clear paste; and uniformly mixing the volatile oil and a solubilizer, adding the mixture into dextrin for uniform stirring, adding powdered sugar and extract powder, performing granulation and screening, and obtaining the infant broad spectrum antidiarrheal granule. The preparation technology for the granule can extract various effective components in the crude medicines to the maximum degree on the premise of considering the efficiency and the cost, and obviously improves the medicine effect of the granule compared with the prior infant broad spectrum antidiarrheal oral liquid.

The invention discloses a quality detection method for a spleen-invigorating, cold-dispersing and antidiarrheal medicine composition, which includes identification and content determination. The existing quality standard is raised, on one hand, a preparation method of thin-layer sample solution identification is simplified, solvent usage, pollution, labor and materials are reduced, and cost is saved; and on the other hand, content tests of cinnamon and fructus piperis longi are added, and by a series of inspection on specificity, linear relation, stability, repeatability and the like, the method conforms to Chinese Pharmacopoeia 2010, quality control in industrial production and quality stability of products are benefited.

The invention relates to a preparation method and a quality detection method of a detoxification antidiarrheal tablet. The antidiarrheal tablet has no adverse effect, toxic effect or side effect in long term clinical application, cannot stimulate an alimentary system, has no side effect on liver or kidney, cannot cause a series of adverse effects such as stomach discomfort, nausea, dizziness and the like, cannot generate drug resistance, and has remarkable effect on treatment on acute enteritis, syndrome drain abdominal distension in traditional Chinese medicine differentiation, abdominal pain and the like compared with traditional antidiarrheal. In preparation process, parts of medicinal materials are made into power, and parts of medicinal materials are extracted, so that effective components of products are ensured, production process is advanced, and production process is controllable. Simultaneously, raw material knowledge composition quercitin with strong specificity is adopted to serve as content control index, quality standard is explicit, quality checking method is advanced, terminal product quality is effectively controlled, and product curative effect can be ensured.

The invention relates to a drink for curing diarrhea. In order to be convenient and practical and to ensure a good diarrhea curing effect and a small side effect, the invention is made of raw materials of raw garlic, alum, pomegranate rind, brown sugar, plantain seed, stove core soil, ginger, pepper, Chinese gall, magnoliavine fruit, and medcinal evodia fruit; and all the raw materials are kilned and then are diluted with pure water to obtain the drink, thereby protecting health better.

The invention discloses antidiarrheal particles which comprise, by weight, 20-40 parts of smoked plums, 20-40 parts of hawthorns and 20-40 parts of guavas. Foodstuff is adopted as raw materials, so that the antidiarrheal particles are non-toxic, free of side effects, capable of relieving diarrhea with astringent, invigorating stomach and helping digest, capable of being used both by adults and children and simple in the preparing method.

The invention is a traditional Chinese medicine combination with nourishing, anti-inflammation, antidiarrheal, hemostatic and analgesic effects for livestock. This traditional Chinese medicine combination is prepared in accordance with following ingredients by weight: 50-100 parts of Artemisia sacrorum Ledeb, 8-16 parts of ginseng, 8-16 parts of Astragalus, 5-10 parts of fructus schisandrae, 8-16 parts of Pericarpium Granati, 20-30 parts of Carthamus tinctorius and 0.1-0.3 part of saffron crocus. Through the clinic research, the set traditional Chinese medicines are successfully obtained. Indications of this traditional Chinese medicine: diarrhea, abdominal pain, loose stool, water stool, and blood stool; the cure rate is over 97%; fowls and livestock can be cured within 3 days in general. The product prepared by an optimal preparation technology as used in the invention has the good stability.

The invention discloses a quality control method of Suxiaozhixie Capsule, which comprises the following steps: identifying the capsule, detecting content according to high performance liquid chromatography: A chromatographic condition and system qualification test, B preparing contrast solution, C preparing testing solution for assay, and D precisely sucking 10 mu l contrast solution and testing solution for assay respectively, injecting into liquid chromatograph, detecting, wherein, labelled amount of berberine hydrochloride in the product is 90-110%.The invention can better control the quality of the capsule, guarantee safety for administration, guide production with rational and strict process control.

The invention belongs to the field of biological medicine, and particularly relates to a composition which adopts natural sources and is used for astringing to arrest diarrhea, and a preparation method of the composition. According to the invention, the raw materials including rice, fortune eupatorium herb, rhizoma atractylodis macrocephalae, guava leaves, folium artemisiae argyi, tea leaves, amomum kwangsiense and the like are processed to obtain the composition. The composition is safe, reliable, good in taste, convenient, and high in adaptability, and has the effects of warming the middle warmer, tonifying spleen, regulating qi and inducing diuresis, can relieve various symptoms caused by diarrhea, promote the recovery of gastrointestinal function, and increase appetite.

The present invention discloses a quick-acting antidiarrheal tablet and its preparation method. Said tablet is divided into general tablet and dispersing tablet. Every general tablet contains 80-160g of berberine hydrochloride, 100-250g of polygonum bistorta extract, 1-150mg of adhesive and 1-50mg of lubricating agent and flow aid, and every dispersing tablet contains 80-160g of berberine hydrochloride, 100-250g of polygonum bistorta extract, 1-200mg of filling agent, 10-200mg of disintegrant, 1-150mg of adhesive and 1-50mg of lubricating agent and flow aid.