Medicament composition for treating children's damp-heat diarrhea induced by spleen insufficiency and preparation method thereof

A technology of spleen-deficiency damp-heat and composition, which is applied in the field of traditional Chinese medicine composition and its preparation technology, and achieves the effect of reducing the dosage of medicine

Active Publication Date: 2009-06-24
重庆希尔安药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Another object of the present invention is to develop a method for preparing a pharmaceutical composition for treating infantile spleen-deficiency damp-heat diarrhea with excellent performance and in line with the standard of "Pharmacopia of the People's Republic of China" by using the ten medicinal

Method used

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  • Medicament composition for treating children's damp-heat diarrhea induced by spleen insufficiency and preparation method thereof
  • Medicament composition for treating children's damp-heat diarrhea induced by spleen insufficiency and preparation method thereof
  • Medicament composition for treating children's damp-heat diarrhea induced by spleen insufficiency and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Use Codonopsis 5g, lotus seeds 5g, white lentils 5g, coptis 1g, scutellaria baicalensis 3g, honeysuckle 5g, Jianqu 3g, hawthorn 4g, plantain seed (salt roast) 4g, dried ginger 1g and ten herbs as raw materials;

[0099] Add water to decoct the above-mentioned ten-flavored raw materials for 2 times, add 10 times the total amount of ten-flavored raw materials for decoction for 2 hours for the first time, and obtain a decoction for later use; add 6 times the total amount of ten-flavored raw materials for the second time decoct in water for 1 hour, combine the decoction, filter, concentrate the filtrate under reduced pressure to 144ml, put it to cool, add ethanol equal to the volume of the concentrated filtrate, and have a concentration of 70%, mix well, let stand for 12 hours, filter After the ethanol is recovered from the filtrate, it is concentrated to a clear paste with a relative density of 1.25 (50-60°C); add 27g of starch and 1.8g of microcrystalline cellulose to the ...

Embodiment 2

[0101] Use Codonopsis 25g, lotus seeds 18g, white lentils 5g, berberine 1g, scutellaria baicalensis 3g, honeysuckle 23g, Jianqu 3g, hawthorn 24g, plantain seed (salt roast) 23g, dried ginger 6g and ten herbs as raw materials;

[0102] Add water to decoct the above-mentioned ten-flavored raw materials for 3 times, add 8 times the amount of the total amount of the ten-flavored raw materials for the first time and decoct for 2 hours to obtain a decoction for later use; add 8 times the amount of the total amount of the ten-flavored raw materials for the second time The decoction was decocted for 2 hours, and the decoction was obtained for later use; for the third time, 6 times the total amount of the ten-flavored raw materials were added to decoct for 1 hour, the decoction was combined, filtered, the filtrate was concentrated under reduced pressure to 500ml, and cooled. Add the same amount of ethanol with a concentration of 80% of the concentrated filtrate, mix well, let stand for ...

Embodiment 3

[0104] Use Codonopsis 20g, lotus seeds 23g, white lentils 18g, berberine 15g, scutellaria baicalensis 12g, honeysuckle 12g, Jianqu 23g, hawthorn 12g, plantain seed (salt roast) 12g, dried ginger 13g and ten herbs as raw materials;

[0105] Add water to decoct the above-mentioned ten-flavored raw materials 3 times, add 8 times the amount of the total amount of the ten-flavored raw materials for the first time and decoct for 1 hour to obtain a decoction for later use; add 6 times the amount of the total amount of the ten-flavored raw materials for the second time decocted in water for 1 hour, and the decoction was obtained for later use; for the third time, add 6 times the amount of the total amount of Shiwei raw materials and decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate to 632ml under reduced pressure, and put it to cool. Add ethanol equal to the volume of the concentrated filtrate and a concentration of 90%, mix well, let stand for 24 hours, fi...

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Abstract

The invention relates to a pharmaceutical composition for treating infantile splenic asthenia and moist heat diarrhea (spleen invigorating and diarrhea arresting pharmaceutical composition) and preparation method thereof. The pharmaceutical composition is prepared from the raw materials including codonopsis pilosula, lotus seed, white hyacinth bean, rhizoma coptidis, Baical Skullcap Root, honeysuckle, massa medicata fermentata, hawthorn, plantain seed and dried ginger. The preparation method comprises: adding water into and then boiling the codonopsis pilosula and other nine raw materials; combining the water solutions, filtering the combined water solution, subjecting a filtrate to vacuum concentration to 144 to 904ml, cooling the filtrate, adding ethanol having the same volume as the filtrate into the filtrate, mixing the mixed solution uniformly, standing the mixed solution for 12 to 24 hours and filtering the mixed solution; after recovery of ethanol, condensing the filtrate and obtaining a clear paste with a specific density of 1.15 to 1.25 (50 to 60 DEG C); adding medicinal accessories into the clear paste, mixing the mixture uniformly and making the mixture into grains; and drying the grains to obtain the pharmaceutical composition. The mixing ratio of crude drugs of the pharmaceutical composition is obtained through scientific selection. The pharmaceutical composition has efficacies of reducing fever and dehumidification, and invigorating spleen and arresting diarrhea and is used for treating infantile splenic asthenia and moist heat diarrhea and addresses both the symptoms and root cause. The spleen invigorating and diarrhea arresting drug prepared by the method improves the utilization rate of active ingredients, can be absorbed completely by human bodies, improves drug effect and is optimal for clinic application.

Description

technical field [0001] The invention relates to the field of a traditional Chinese medicine composition and its preparation process, more specifically to a medicinal composition for treating damp-heat diarrhea due to spleen deficiency in children and a preparation method thereof. Background technique [0002] Diarrhea is one of the main diseases of the digestive system in children. According to the statistics of the health department, 836 million people suffer from diarrhea every year in my country, of which 250 million are children under 5 years old. The occurrence of diarrhea in children is mainly characterized by increased stool frequency, thin or watery stool. At present, there are many problems in the use of diarrheal diseases in our country. Among them, the abuse of antibiotics is quite serious, which not only causes economic waste, but also leads to various hazards such as the growth of drug-resistant bacteria and flora imbalance. Due to the long-term use of broad-spe...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K47/40A61K9/00A61K9/16A61K9/20A61K9/48A61P1/12
Inventor 唐德江陈犁
Owner 重庆希尔安药业有限公司
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