Radix cynanchi bungei extract and application thereof

A technology of Baishouwu and its extracts, which is applied in the field of Baishouwu extract and its application in the preparation of tranquilizers, and can solve the problems of no research on Baishouwu stems and leaves

Pending Publication Date: 2022-07-29
湖南中嘉生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the current prior art has only studied the effect of the roots of Baishouwu, but there is no relevant literature on the stems and leaves of Baishouwu.

Method used

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  • Radix cynanchi bungei extract and application thereof
  • Radix cynanchi bungei extract and application thereof
  • Radix cynanchi bungei extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Comparison of Baishouwu root and Baishouwu stem and leaf extract

[0040] 1. Experimental method

[0041] 1.1 Instruments and reagents

[0042] Agilent 1260 liquid chromatograph, OpenLab CDS 2.6 chromatography workstation, DAD detector, Venusil MPC18 column (250mm×4.6mm, 5μm), ultrasonic cleaner (KM7200DE, Kunshan Meimei Ultrasonic Instrument Co., Ltd.), methanol (chromatographically pure, TEDIA ), acetonitrile (chromatographic grade, TEDIA), phosphoric acid (analytical grade, Sinopharm Chemical Reagent Co., Ltd.), ultrapure water using a water purifier (Direct-Q○ R 5UV-R, Millipore, U.S.A.), the roots and leaves of Baishouwu were provided by Yaoyongwang Food Co., Ltd., Jiangyong County, Hunan Province. ), identified by Professor Liu Tas of Hunan University of Traditional Chinese Medicine as the dry root and stem and leaf of Cynanchum auriculatum Royle ex Wight., see the identification report for details.

[0043] The specific characteristics of its stems and leaves ...

Embodiment 2

[0088] Effects of Chinese herbal extracts on autonomous activity in mice

[0089] 1 The purpose of the test

[0090] The autonomous activity test of mice was used to observe the effects of different tested Chinese herbal extracts on the number of activities in mice, and to evaluate the sedative effects of various Chinese herbal extracts on mice.

[0091] 2 Test materials

[0092] 2.1 Test article

[0093] Baishouwu (Cynanchum auriculatum Royle ex Wight) stem and leaf extract, extraction method is the same as Example 1, batch number: 20211205, content: 1g crude drug / mL, character: light brown to brown liquid, valid until: 2022.01. 25; Baishouwu root extract, batch number: 20211202, content: 1g crude drug / mL, properties: light brown to brown liquid, valid until: 2022.01.25; fried jujube seed extract, batch number: 20211211, content: 1g crude drug / mL, properties: light brown to brown liquid, valid until: 2022.01.25; extraction method: take sour jujube seeds, add water to deco...

Embodiment 3

[0117] Effects of Chinese herbal extracts on phenobarbital sodium subthreshold hypnosis

[0118] 1 The purpose of the test

[0119] By observing the effect of Chinese herbal extracts in synergistic subthreshold hypnotic doses of phenobarbital sodium on the number of mice falling asleep, the hypnotic effects of different Chinese herbal extracts on mice were evaluated.

[0120] 2 Test materials

[0121] 2.1 Test article

[0122] Baishouwu stem and leaf extract, batch number: 20211205, content: 1g crude drug / mL, properties: light brown to brown liquid, validity period: 2022.01.25; Baishouwu root extract, batch number: 20211202, content: 1g crude drug / mL, properties: light brown to brown liquid, valid until: 2022.01.25; fried jujube seed extract, batch number: 20211211, content: 1g crude drug / mL, properties: light brown to brown liquid, valid until: 2022.01.25; extraction The method is: take sour jujube kernels, add water for three times, add 8 times the amount of water for th...

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Abstract

The invention belongs to the field of plant extracts, and particularly relates to a radix cynanchi bungei extract (Cynanchum auricultum Royle ex Wight as a Shummoraceae plant) and an application of the radix cynanchum auricultum Royle ex Wight extract in preparation of a nerve soothing medicine. The preparation method of the radix cynanchi bungei extract comprises the following steps: crushing stems and leaves of radix cynanchi bungei, adding 6-15 times of water for soaking, decocting and filtering; adding 4-10 times of water into filter residues, decocting, and filtering; decocting the decoction filter residue with 4-8 times of water, and then filtering; and combining the three filtrates, and concentrating under reduced pressure to obtain the radix cynanchi bungei extract. It is found for the first time that effective components of stems and leaves of radix cynanchi bungei and tuberous roots of radix cynanchi bungei are completely different, and the effects of the stems and leaves and tuberous roots are also completely different. The analysis of the effective components of the stems and leaves of the radix cynanchi bungei shows that the radix cynanchi bungei has very good effects of soothing the nerves and helping sleep.

Description

technical field [0001] The invention belongs to the field of plant extracts, in particular to a Baishouwu extract and its application in the preparation of sedatives. Background technique [0002] With the acceleration of the pace of life, the increasing pressure of social competition and the change of living habits, the incidence of insomnia is increasing year by year. Modern medicine believes that insomnia is a negative subjective feeling that individuals are dissatisfied with sleep time and / or sleep quality and seriously affect daytime social function. In addition to serious sleep problems, insomnia patients are often accompanied by different degrees of depression and anxiety and other negative emotions, which are easy to induce various psychological and physical diseases, which seriously affect the daily work and quality of life of patients. Although Western medicine has achieved certain curative effects in the treatment of insomnia, there are still many problems such a...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61K36/725A61P25/20A61P25/00A61K127/00A61K135/00
CPCA61K36/27A61K36/725A61P25/20A61P25/00A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 王毅清谭桂山张乐佳宋太发宋军周书奥
Owner 湖南中嘉生物医药有限公司
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