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Preparation method of fructus mume and green tea antidiarrheal effervescent tablet

A technology for antidiarrheal and effervescent tablets of green plum is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., to achieve the effects of being convenient to take, improving adhesion and taste, and improving clinical efficacy

Inactive Publication Date: 2015-01-07
上海海虹实业(集团)巢湖今辰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no effervescent tablet with similar raw materials and effects as Lumei Zhixie Granules, so it is necessary to develop a preparation method for Lumei Zhixie Effervescent Tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0017] The preparation method of the Lumei antidiarrheal effervescent tablet of this specific embodiment comprises the following steps:

[0018] Step 1, crush raw materials: 330 grams of hawthorn, 330 grams of black plum, and 330 grams of green tea;

[0019] Step 2, add 4000 grams of water to the crushed raw materials in step 1, decoct for 2 hours, then filter, decoct for another 2 hours, filter and combine the filtrate;

[0020] Step 3, concentrating the filtrate obtained by filtering in step 2 to make a clear paste;

[0021] Step 4, add 50 grams of lactose to the clear paste obtained in Step 3, and dry under reduced pressure to obtain 900-1000 grams of dry cream powder;

[0022] Step 5. Take 500 grams of dry paste powder obtained in step 4, add 10 grams of microcrystalline cellulose, 20 grams of talcum powder, 200 grams of citric acid, and 300 grams of sodium bicarbonate, mix well, and press into tablets to obtain the product.

specific Embodiment 2

[0023] The preparation method of the Lumei antidiarrheal effervescent tablet of this specific embodiment comprises the following steps:

[0024] Step 1, crush raw materials: 330 grams of hawthorn, 330 grams of black plum, and 330 grams of green tea;

[0025] Step 2, add 4000 grams of water to the crushed raw materials in step 1, decoct for 2 hours, then filter, decoct for another 2 hours, filter and combine the filtrate;

[0026] Step 3, concentrating the filtrate obtained by filtering in step 2 to make a clear paste;

[0027] Step 4, add 70 grams of lactose to the clear cream obtained in step 3, and dry under reduced pressure to obtain 900-1000 grams of dry cream powder;

[0028] Step 5. Take 500 grams of dry cream powder obtained in step 4, add 20 grams of microcrystalline cellulose, 50 grams of talcum powder, 300 grams of citric acid, and 200 grams of sodium bicarbonate, mix well, and press into tablets to obtain the product.

specific Embodiment 3

[0029] The preparation method of the Lumei antidiarrheal effervescent tablet of this specific embodiment comprises the following steps:

[0030] Step 1, crush raw materials: 330 grams of hawthorn, 330 grams of black plum, and 330 grams of green tea;

[0031] Step 2, add 4000 grams of water to the crushed raw materials in step 1, decoct for 2 hours, then filter, decoct for another 2 hours, filter and combine the filtrate;

[0032] Step 3, concentrating the filtrate obtained by filtering in step 2 to make a clear paste;

[0033] Step 4, add 90 grams of lactose to the clear cream obtained in step 3, and dry under reduced pressure to obtain 900-1000 grams of dry cream powder;

[0034] Step 5: Take 500 grams of dry cream powder obtained in step 4, add 50 grams of microcrystalline cellulose, 10 grams of talcum powder, 150 grams of citric acid, and 150 grams of sodium bicarbonate, mix well, and press into tablets to obtain the product.

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Abstract

The invention discloses a preparation method of a fructus mume and green tea antidiarrheal effervescent tablet. The preparation method comprises the steps as follows: step one, raw materials including hawthorn, fructus mume and green tea are ground; step two, the ground raw materials in the step one are added with water, decocted and filtered; step three, filtrate obtained through filtration in the step two is concentrated to prepare clear paste; step four, the clear paste obtained in the step three is dried under reduced pressure to prepare dried paste powder; and step five, microcrystalline cellulose, talcum powder and an effervescent disintegrant are added to the dried paste powder obtained in the step four, uniformly mixed and tableted to obtain the fructus mume and green tea antidiarrheal effervescent tablet. The preparation method of the fructus mume and green tea antidiarrheal effervescent tablet fills up the blank of fructus mume and green tea antidiarrheal effervescent tablets and meets actual production requirements and consumer demands.

Description

technical field [0001] The invention relates to a preparation method of Lvmei Zhixie effervescent tablet, which belongs to the technical field of pharmaceutical product production. Background technique [0002] Lumei Zhixie Granule is a well-known antidiarrheal drug for digestion and stagnation, which is mainly used to treat diarrhea, abdominal distension, indigestion and other diseases. Effervescent tablet is a common form of pharmaceutical preparation, which has the advantages of rapid disintegration, convenient administration, rapid onset of action, high bioavailability, and can improve clinical efficacy; it is especially suitable for children, the elderly and those who have difficulty swallowing pills of patients. The taste of the seasoned effervescent tablet is better, and the good medicine is no longer bitter, which makes the patient more willing to accept it; in addition, the large amount of foam generated due to disintegration increases the direct contact between th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K9/46A61P1/12
CPCA61K36/734A61K9/0007A61K9/2054A61K36/736A61K36/82A61K2236/15A61K2236/331A61K2236/51A61K2236/53
Inventor 梁延波刘声伟孔贵平
Owner 上海海虹实业(集团)巢湖今辰药业有限公司
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