Traditional Chinese medicine compound ointment based on four-cavity qi-blood coordinated regulation and preparation process thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compound ointment, and particularly discloses traditional Chinese medicine compound ointment based on four-cavity qi-blood coordinated regulation and a preparation process thereof. The compound ointment comprises the following raw materials in parts by weight: 6-15 parts of radix bupleuri, 9-18 parts of scutellaria baicalensis, 20-40 parts of codonopsis pilosula, 9-30 parts of fried perillaseed, 3-9 parts of pericarpium zanthoxyli, 6-12 parts of honey-fried licorice root, 15-30 parts of jujube, 5-10 parts of cassia twig, 15-30 parts of gypsum, 30-50 parts of raw oyster shell, 10-30 parts of semen plantaginis, 6-15 parts of cooked rhubarb and the like. The ointment prepared by the formula disclosed by the invention can realize four-cavity synergistic regulation and improve the qi and blood state of the whole body in a targeted manner. Through targeted regulation of qi and blood disorder states of a cranial cavity, a thoracic cavity, an abdominal cavity and a pelvic cavity of a human body, headache and insomnia caused by qi and blood rising of the cranial cavity, chest distress and breast nodules caused by qi stagnation and blood stasis of the thoracic cavity, abdominal distension and constipation caused by middle-jiao transportation loss of the abdominal cavity, and menstrual disorder caused by disorder of Chong and Ren meridians of the pelvic cavity can be effectively relieved; therefore, the dynamic balance of qi and blood of the whole body is realized, and the whole health of human body is powerfully guaranteed.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine compound ointment, and particularly relates to a traditional Chinese medicine compound ointment based on four-cavity gas-blood synergistic regulation and a preparation process thereof. BACKGROUND

[0002] Gas and blood are two basic substances in the human body, which play a very important role in human life activities. Gas has the functions of promoting and regulating, warming and moistening, defense, fixation and mediation on the human body. Blood has the functions of nourishing and transforming spirit on the human body.

[0003] However, there are many limitations in similar products and technologies on the market, which cannot meet the complex health needs of modern people.

[0004] The common single-target supplement product on the market is composed of radix codonopsis, rhizoma atractylodis macrocephalae, and poria cocos, and only plays a role in treating deficiency of both qi and blood. However, for the complex pathogenesis of “deficiency and excess mixed, cold and heat mixed” commonly existing in modern people, the product cannot effectively respond and regulate.

[0005] Secondly, the local dredging product mainly uses fructus pruni, safflower, and radix bupleuri as main raw materials, and focuses on promoting blood circulation to remove blood stasis. However, in the regulation process, there is a lack of synergistic regulation of middle-cavity gasification and lower-cavity uterus, and long-term or improper use may easily lead to “damaging qi and damaging normal function”.

[0006] Thirdly, many ointments on the market use medicinal food, such as donkey-hide gelatin and rhizoma polygonati, and long-term use of such ointments may easily cause phlegm stagnation or hyperactivity of deficiency fire, such as thick and greasy tongue fur, oral ulcer, and other uncomfortable symptoms.

[0007] In summary, most of the products on the market have single compatibility dimension, and most of them follow a single regulation dimension such as “tonifying qi”, “nourishing blood”, or “clearing heat”, which cannot achieve dynamic balance of cold and heat, ascending and descending, and tonifying and purging, so that the prescription is limited in dealing with complex diseases. Secondly, there is a lack of synergistic regulation of four cavities, and for the complex pathogenesis of cranial cavity blood stasis, chest cavity qi stagnation and blood stasis, abdominal cavity dysfunction, and pelvic cavity dysfunction, there is a lack of systematic regulation scheme, and the function of each cavity cannot be comprehensively adjusted. Thirdly, there is a safety risk, and some products contain red ginseng and aconite, which may cause blood pressure fluctuations and increase the burden on liver and kidney functions, and may pose a potential risk to human health.

[0008] In view of the above deficiencies of the prior art, there is an urgent need for a technical solution that can overcome these limitations, achieve multi-dimensional compatibility, multi-cavity synergistic regulation, and higher safety. SUMMARY

[0009] The present application aims to provide a traditional Chinese medicine compound ointment based on four-cavity qi-blood synergistic regulation and a preparation process thereof to solve the problems in the above background art.

[0010] To achieve the above-mentioned object, the present application provides the following technical solution.

[0011] The traditional Chinese medicine compound ointment based on four-cavity qi-blood synergistic regulation comprises the following raw materials by weight: Radix Bupleuri 6-15 parts, Radix Scrophulariae 9-18 parts, Radix Codonopsis 20-40 parts, Fried Semen Litchi 9-30 parts, Sichuan Pepper 3-10 parts, Fried Licorice 6-12 parts, Jujube 10-30 parts, Ramulus Cinnamomi 5-10 parts, Gypsum Fibrosum 15-30 parts, Concha Margaritiferae 30-50 parts, Semen Plantaginis 10-30 parts, Rhei Radix et Rhizoma Praeparatum 6-15 parts, Pericarpium Citri Reticulatae 9-30 parts, Radix Paeoniae Alba 12-30 parts, Flos Lilii 10-30 parts, Lignum Cinnamomi 8-15 parts, Radix Salviae Miltiorrhizae 15-30 parts, Radix Curcumae 10-20 parts, Fructus Trichosanthis 12-35 parts, and Fructus Schisandrae Chinensis 6-15 parts.

[0012] Preferably, the compound ointment comprises the following raw materials by weight: Radix Bupleuri 15 parts, Radix Scrophulariae 15 parts, Radix Codonopsis 30 parts, Fried Semen Litchi 30 parts, Sichuan Pepper 10 parts, Fried Licorice 10 parts, Jujube 10 parts, Ramulus Cinnamomi 10 parts, Gypsum Fibrosum 30 parts, Concha Margaritiferae 30 parts, Semen Plantaginis 30 parts, Rhei Radix et Rhizoma Praeparatum 10 parts, Pericarpium Citri Reticulatae 30 parts, Radix Paeoniae Alba 30 parts, Flos Lilii 30 parts, Lignum Cinnamomi 10 parts, Radix Salviae Miltiorrhizae 30 parts, Radix Curcumae 15 parts, Fructus Trichosanthis 30 parts, and Fructus Schisandrae Chinensis 15 parts.

[0013] The preparation process of the traditional Chinese medicine compound ointment based on four-cavity qi-blood synergistic regulation comprises the following steps.

[0014] S1, raw material pretreatment

[0015] The raw materials are weighed according to the weight parts, and the Concha Margaritiferae is calcined at 900℃ for 1.5 hours and then quenched with vinegar three times; the Rhei Radix et Rhizoma Praeparatum is steamed with rice wine according to a ratio of 2:1 for 4 hours, and the other raw materials are pretreated by cleaning and crushing (through an 80-100 mesh sieve).

[0016] S2, subsection extraction and refinement

[0017] Volatility component extraction: the pretreated Radix Bupleuri, Ramulus Cinnamomi, and Sichuan Pepper are extracted by subcritical water extraction, the temperature is controlled at 120-140℃, the pressure is controlled at 0.8-1.2 MPa, the extraction liquid is collected and filtered to obtain the volatility component extraction liquid;

[0018] Non-volatility component extraction: the pretreated Radix Codonopsis, Radix Salviae Miltiorrhizae, and calcined Concha Margaritiferae are added with cellulase and pectinase, the system pH is adjusted to 4.5-5.5, and the enzymatic hydrolysis assisted extraction is carried out at 45-55℃, and then filtered to obtain the non-volatility component extraction liquid;

[0019] The remaining raw materials (huangqi, fried suzi, chenpi, white peony root, wuyao, jujube, cucumis, melon) are extracted by a conventional water extraction method, filtered to obtain corresponding extract, and refined, centrifuged, and ultrafiltered;

[0020] S3, mixing and concentrating

[0021] All the refined extract is combined and gradiently reduced pressure concentrated until the relative density reaches 1.30-1.35 at 65 DEG C, then the acid and sweet components such as lily, schisandra chinensis and the prepared raw gypsum powder are added, stirred and mixed to form a paste;

[0022] The paste is added with jujube and honey liquor extract flavoring components, and the pH value of the system is adjusted to 6.0-6.5 with honey, and then fully stirred and mixed;

[0023] S4, low temperature drying

[0024] The mixed paste is placed in a vacuum belt drying equipment and dried at 50-60 DEG C, and the moisture content of the product after drying is controlled to be less than or equal to 5%, thereby obtaining a dried product;

[0025] S5, sterilization and filling

[0026] Co-60 source is used for irradiation sterilization, and the sterilization dose is controlled to be 8-12 kGy;

[0027] The sterilized material is filled according to the specifications, thereby obtaining a finished product.

[0028] Compared with the prior art, the beneficial effects of the present application are:

[0029] The prepared ointment of the present application can realize four-cavity synergistic regulation and target improvement of the whole body blood state. By specifically regulating the blood and qi disorder state of the four cavities of the human body, i.e. the cranial cavity, the thoracic cavity, the abdominal cavity and the pelvic cavity, the headache and insomnia caused by the upward flow of blood and qi in the cranial cavity, the chest distress and breast nodules caused by blood stasis in the thoracic cavity, the abdominal distension and constipation caused by the failure of the middle jiao in the abdominal cavity, and the menstrual disorder caused by the imbalance of the uterus and the chong meridian in the pelvic cavity, etc. can be effectively relieved, thereby realizing the dynamic balance of the whole body blood and qi, and providing a strong guarantee for the overall health of the human body.

[0030] It has a composite function and a wide range of applications. The present application has the effects of preventing diseases, improving physical fitness and assisting in the treatment of chronic diseases (such as metabolic syndrome, chronic fatigue syndrome, functional gastrointestinal disease, etc.), and can meet the diversified needs of modern people in health maintenance and disease conditioning, and is more practical than the single-function products in the prior art.

[0031] Breaking through traditional limitations, the compatibility is scientific and rational. With the core compatibility principles of "harmony between cold and heat, balanced ascending and descending, and combined tonification and purgation," for example, Scutellaria baicalensis and Cinnamon twig are combined to regulate cold and heat, Bupleurum chinense and Perilla seed are combined to harmonize ascending and descending, and Codonopsis pilosula and Rhubarb are combined to achieve tonification and purgation. This effectively breaks through the drawbacks of existing similar technologies that are limited to a single viscera or qi and blood syndrome type, solves the problem of traditional qi and blood conditioning products with a single dimension of action, and enables prescriptions to more comprehensively address complex pathogenesis.

[0032] This product is safer and suitable for long-term use. This product avoids the use of strong medicinal materials such as red ginseng and aconite, reducing potential safety risks such as blood pressure fluctuations and liver and kidney function burdens caused by long-term use. Furthermore, by scientifically combining ingredients to balance cold and heat and coordinate deficiency and excess, it addresses the problem of traditional products easily causing cold and heat imbalance or deficiency and excess bias with long-term use, thereby improving safety and applicability. DETAILED DESCRIPTION

[0033] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0034] Example 1:

[0035] 1. Drug composition (by weight)

[0036] 10 parts of Bupleurum, 12 parts of Scutellaria, 30 parts of Codonopsis, 12 parts of stir-fried Perilla seeds, 5 parts of Sichuan pepper, 9 parts of roasted Licorice root, 22 parts of Jujube, 7 parts of Cinnamon twig, 23 parts of Gypsum, 40 parts of Raw Oyster, 15 parts of Plantago seeds, 11 parts of Cooked Rhubarb, 13 parts of Tangerine peel, 18 parts of White Peony, 15 parts of Lilium, 12 parts of Linderae, 23 parts of Salvia miltiorrhiza, 15 parts of Curcuma, 18 parts of Trichosanthes, and 9 parts of Schisandra chinensis.

[0037] 2. Preparation Example

[0038] Raw material pretreatment (S1): Weigh the raw materials according to the above weight parts, calcine the raw oysters at 900°C for 1.5 hours, and then quench them with vinegar three times; steam the cooked rhubarb with rice wine, mix it with the medicinal materials in a ratio of 2:1, and steam it for 4 hours; clean and crush the raw gypsum into a fine powder (pass through a 120-150 mesh sieve) for later use; and pretreat the other raw materials by cleaning and crushing (passing through an 80-100 mesh sieve).

[0039] Segmented extraction and purification (S2):

[0040] Extraction of volatile components: take 10 parts of pre-processed Radix Bupleuri, 7 parts of Ramulus Cinnamomi and 5 parts of Fructus Zanthoxyi, adopt subcritical water extraction, control temperature at 120-140℃ and pressure at 0.8-1.2 MPa, collect the extraction liquid and filter to obtain the volatile component extraction liquid.

[0041] Extraction of non-volatile components: take 30 parts of Radix Codonopsis, 23 parts of Radix Salviae Miltiorrhizae and 40 parts of calcined Ostreae Concha, add cellulase and pectinase, adjust the pH of the system to 4.5-5.5, and perform enzymatic hydrolysis assisted extraction at 45-55℃, then filter after extraction to obtain the non-volatile component extraction liquid.

[0042] Extraction of the rest of the raw materials: take 12 parts of Radix Scrophulariae, 12 parts of Fried Semen Torreyae, 15 parts of Fructus Plantaginis, 13 parts of Pericarpium Citri Reticulatae, 18 parts of Radix Paeoniae Alba, 12 parts of Lingshui Yuyan, 15 parts of Curcuma, 18 parts of Fructus Trichosanthis, and 15 parts of Schisandra Chinensis, extract according to the conventional water extraction method, and filter to obtain the corresponding extraction liquid. The above three kinds of extraction liquid are refined respectively, and are sequentially subjected to centrifugal and ultrafiltration treatment.

[0043] Mixing and concentration (S3): combine all the refined extraction liquids, perform gradient vacuum concentration, and when the relative density reaches 1.30-1.35 at 65℃, add 15 parts of Lily, 9 parts of Schisandra Chinensis and 23 parts of prepared raw gypsum powder, stir uniformly to form a paste; add 22 parts of Jujube and 9 parts of Fried Licorice Root extraction liquid as the flavoring component to the paste, adjust the pH value of the system to 6.0-6.5 with honey, and mix thoroughly.

[0044] Low-temperature drying (S4): place the mixed paste in a vacuum belt drying equipment and dry at 50-60℃, control the moisture content of the product after drying to be ≤5%, and obtain the dried product.

[0045] Sterilization and filling (S5): use Co-60 source for irradiation sterilization, and control the sterilization dose at 8-12 kGy; the sterilized material is filled according to the specifications, and the finished product is obtained.

[0046] Example Two:

[0047] I. Pharmaceutical composition (by weight)

[0048] Radix Bupleuri 15 parts, Radix Scrophulariae 15 parts, Radix Codonopsis 30 parts, Fried Semen Torreyae 30 parts, Fructus Zanthoxyi 10 parts, Fried Licorice Root 10 parts, Ramulus Cinnamomi 10 parts, raw gypsum 30 parts, raw Ostreae Concha 30 parts, Fructus Plantaginis 30 parts, cooked Rhubarb 10 parts, Pericarpium Citri Reticulatae 30 parts, Radix Paeoniae Alba 30 parts, Lily 30 parts, Lingshui Yuyan 10 parts, Radix Salviae Miltiorrhizae 30 parts, Curcuma 15 parts, Fructus Trichosanthis 30 parts, and Schisandra Chinensis 15 parts.

[0049] II. Preparation Example

[0050] Raw material pretreatment: according to the above weight parts, each raw material was weighed, and raw oyster was calcined at 900℃ for 1.5 hours, followed by three times of vinegar quenching; cooked rhubarb was steamed with rice wine, mixed according to a ratio of 2:1 of rice wine and medicinal materials, and steamed for 4 hours; raw gypsum was cleaned and ground into fine powder (passed through a 120-150 mesh screen) for use; other raw materials were cleaned, ground (passed through an 80-100 mesh screen) and pretreated.

[0051] Volatile component extraction: 15 parts of pretreated bupleurum, 10 parts of cassia twig, and 10 parts of szechuan pepper were taken and subjected to subcritical water extraction, with the temperature controlled at 120-140℃ and the pressure at 0.8-1.2MPa. The extraction liquid was collected and filtered to obtain the volatile component extraction liquid.

[0052] Non-volatile component extraction: 30 parts of pretreated radix codonopsis, 30 parts of salvia miltiorrhiza, and 30 parts of calcined raw oyster were taken, and cellulase and pectinase were added to adjust the pH of the system to 4.5-5.5. Enzymatic hydrolysis was carried out at 45-55℃, and after extraction was completed, filtration was performed to obtain the non-volatile component extraction liquid.

[0053] Rest of the raw material extraction: 15 parts of radix scrophulariae, 30 parts of fried semen astragali, 30 parts of plantago seed, 30 parts of dried tangerine or orange peel, 30 parts of radix paeoniae alba, 10 parts of lindera, 15 parts of curcuma, and 30 parts of trichosanthes kirilowii were taken and subjected to conventional water extraction. After filtration, the corresponding extraction liquid was obtained. The above three kinds of extraction liquids were refined respectively, and were subjected to centrifugation and ultrafiltration treatment in turn.

[0054] Mixing and concentration: all the refined extraction liquids were combined and subjected to gradient reduced pressure concentration. When the relative density reached 1.30-1.35 at 65℃, 30 parts of lily, 15 parts of schisandra chinensis, and 30 parts of reserved raw gypsum powder were added, and the mixture was stirred uniformly to form a paste. The extraction liquid of 10 parts of jujube and 10 parts of fried licorice was added as a flavoring component, the pH value of the system was adjusted to 6.0-6.5 with honey, and the mixture was thoroughly stirred and mixed.

[0055] Low-temperature drying (S4): the mixed paste was placed in a vacuum belt drying equipment and dried at 50-60℃, and the moisture content of the product after drying was controlled to be ≤5%, to obtain a dried product.

[0056] Sterilization and filling (S5): Co-60 source was used for irradiation sterilization, and the sterilization dose was controlled at 8-12kGy. The sterilized material was filled according to the specifications, and the finished product was obtained.

[0057] Experiments were carried out according to the contents prepared in Example Two;

[0058] Experimental animals: SPF level SD rats, male, weighing 200-220g, used for animal experiments; 50 cases of patients with metabolic syndrome, meeting the relevant diagnostic criteria, used for clinical trials.

[0059] Experimental method

[0060] Animal experiment (verify multi-target synergistic effect)

[0061] 40 SD rats were randomly divided into blank control group and administration group, 20 rats in each group.

[0062] The administration group was given the compound ointment by gavage at a dose of 10g / kg of body weight, and the blank control group was given the same amount of normal saline by gavage, once a day, for 4 weeks of continuous administration.

[0063] 24 hours after the last administration, blood was taken from the abdominal aorta, and serum was separated by centrifugation, and the content of CRP (C-reactive protein) and the activity of SOD (superoxide dismutase) in the serum were detected.

[0064] Clinical trial (verify the advantage of preventing and treating chronic diseases)

[0065] 50 patients with metabolic syndrome were selected, and they were continuously administered with the compound ointment, 10g each time, twice a day, for 12 weeks of continuous administration.

[0066] Before and after taking for 12 weeks, the fasting blood glucose and waist circumference of the patients were detected, and the liver function related indexes (such as glutamic-pyruvic transaminase, glutamic-oxalacetic transaminase, etc.) were detected.

[0067] Experimental results

[0068] Animal experiment results

[0069] The serum CRP content of the administration group of rats was reduced by 28% compared with the blank control group, and the difference was statistically significant (P<0.05), indicating that the ointment has anti-inflammatory effect.

[0070] The serum SOD activity of the administration group of rats was increased by 35% compared with the blank control group, and the difference was statistically significant (P<0.05), indicating that the ointment has antioxidant effect, and verifies the gas-blood dual regulation mechanism.

[0071] Clinical trial results

[0072] After 12 weeks of continuous administration, the fasting blood glucose of 50 patients with metabolic syndrome was reduced by 18%, and the waist circumference was reduced by 7.2cm compared with before administration, and the differences were statistically significant (P<0.05).

[0073] All patients did not have abnormal liver function reports during the trial period, indicating that the ointment has good safety in the auxiliary treatment of metabolic syndrome.

[0074] All components of the present application meet the requirements of Chinese Pharmacopoeia and the national drug and food homologous directory, and the safety is verified by acute toxicity test (LD 50 >20g / kg) and 28-day subchronic toxicity test.

[0075] Cold and heat rise and fall compatibility can adapt to different constitutions (such as Huangqin increasing to 18 parts for yin deficiency and fire exuberance, and Guizhi increasing to 10 parts for yang deficiency and cold stagnation).

[0076] Industrial production efficiency: enzyme-assisted extraction technology increases the extraction rate of tanshinone II A to 92% (traditional water extraction method is only 65%), and energy consumption is reduced by 35%; vacuum belt drying process retains more than 95% of heat-sensitive ingredients (such as saikosaponin), which is better than traditional spray drying (80-85%).

[0077] Based on the above content of the application, through four-cavity linkage adjustment: three-dimensional regulation of cranial cavity (Chaihu, Huangqin clearing head and eyes), chest cavity (Gualou, Yujin broadening chest and resolving knots), abdominal cavity (Dangshen, Zhigancao tonifying middle and transporting spleen), and pelvic cavity (Danshen, Wuyao regulating chong and ren).

[0078] Dynamic compatibility balance: three-element energy network of cold and heat ratio (shengshigao clearing heat + guizhi warming and unblocking), ascending and descending synergy (chaihu ascending and suzi descending), and complementary and subtractive combination (dazao tonifying blood + shudaohuang purging bowels);

[0079] Four-cavity target ratio group:

[0080] Cranial cavity group (Chaihu: Huangqin: Shengshigao = 1:1:2.5) - clearing head and eyes, and reducing floating fire;

[0081] Chest cavity group (Gualou: Yujin: Danshen = 1:0.7:1.5) - broadening chest and resolving knots, and activating blood and unblocking collaterals;

[0082] Abdominal cavity group (Dangshen: Zhigancao: Chenpi = 3:0.6:1.5) - tonifying middle and regulating qi movement;

[0083] Pelvic cavity group (Wuyao: Baishao: Wweizi = 1:1.5:1.5) - regulating chong and ren, and astringing yin blood.

[0084] It should be understood that, during the development of any actual implementation, numerous implementation-specific decisions can be made. Such development efforts, while possibly complex and time-consuming, would nevertheless be routine undertaking for those of ordinary skill in the art having the benefit of this disclosure, and such development efforts would not require undue experimentation to achieve this disclosure.

[0085] It should be noted that the above examples are only used to illustrate the technical solutions of the present application and not limit the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present application, and all should be covered in the scope of the claims of the present application.

Claims

1. A Chinese medicine compound ointment based on the coordinated regulation of qi and blood in four cavities, characterized in that: The compound ointment includes the following raw materials in parts by weight: 6-15 parts of bupleurum, 9-18 parts of scutellaria, 20-40 parts of codonopsis, 9-30 parts of stir-fried perilla seeds, 3-10 parts of Sichuan pepper, 6-12 parts of roasted licorice, 10-30 parts of jujube, 5-10 parts of cinnamon twig, 15-30 parts of gypsum, 30-50 parts of raw oyster, 10-30 parts of plantain seeds, 6-15 parts of cooked rhubarb, 9-30 parts of tangerine peel, 12-30 parts of white peony root, 10-30 parts of lily, 8-15 parts of lindera, 15-30 parts of salvia miltiorrhiza, 10-20 parts of curcuma, 12-35 parts of trichosanthes, and 6-15 parts of schisandra chinensis.

2. The Chinese medicine compound ointment based on the coordinated regulation of qi and blood in four cavities according to claim 1, characterized in that: The compound ointment includes the following raw materials in parts by weight: 15 parts of bupleurum, 15 parts of scutellaria, 30 parts of codonopsis, 30 parts of stir-fried perilla seeds, 10 parts of Sichuan pepper, 10 parts of roasted licorice, 10 parts of jujube, 10 parts of cinnamon twig, 30 parts of gypsum, 30 parts of raw oyster, 30 parts of plantain seeds, 10 parts of cooked rhubarb, 30 parts of tangerine peel, 30 parts of white peony root, 30 parts of lily, 10 parts of lindera, 30 parts of salvia miltiorrhiza, 15 parts of curcuma, 30 parts of trichosanthes, and 15 parts of schisandra chinensis.

3. The preparation process of the Chinese medicine compound ointment based on the coordinated regulation of four-cavity qi and blood according to claim 1, characterized in that: The following steps are involved: S1. Raw material pretreatment: Weigh each raw material by weight. Calcine the raw oysters at 900°C for 1.5 hours and then quench them with vinegar three times. Steam the cooked rhubarb with rice wine: mix the rice wine and the medicinal material in a ratio of 2:1 and steam for 4 hours. Pre-process the other raw materials by cleaning and crushing (passing through an 80-100 mesh sieve). S2. Segmented extraction and purification Extraction of volatile components: extract the pretreated bupleurum root, cinnamon twig and Sichuan pepper with subcritical water at a controlled temperature of 120-140°C and a pressure of 0.8-1.2 MPa. Collect and filter the extract to obtain a volatile component extract. Extraction of non-volatile components: Take pre-treated Codonopsis pilosula, Salvia miltiorrhiza, and calcined raw oysters, add cellulase and pectinase, adjust the pH of the system to 4.5-5.5, perform enzymatic hydrolysis-assisted extraction at 45-55°C, and filter after extraction to obtain a non-volatile component extract; The remaining raw materials (Scutellaria baicalensis, stir-fried perilla seeds, Plantago seeds, dried tangerine peel, white peony root, Linderae striata, Curcuma aromatica, Trichosanthes kirilowii) were extracted by conventional water extraction method, filtered to obtain corresponding extracts, and then purified, centrifuged and ultrafiltered with the above two extracts respectively; S3, mixed concentration Combine all the refined extracts and perform gradient vacuum concentration until the relative density reaches 1.30-1.35 at 65°C, then add lily, schisandra chinensis and other acidic and sweet yin components and the reserved gypsum powder, stir evenly to form a paste; Add jujube and licorice extract to the paste, adjust the pH value of the system to 6.0-6.5 with honey, and stir thoroughly. S4, low temperature drying The mixed paste is placed in a vacuum belt drying device and dried at 50-60°C, and the moisture content of the dried product is controlled to be ≤5% to obtain a dried product; S5, sterilization filling Use Co-60 source for irradiation sterilization, and the sterilization dose is controlled at 8-12kGy; The sterilized materials are filled according to specifications to obtain the finished product.