Special medical application formula and preparation method of selenium-rich ginseng medicinal and edible herbal liquid

Abstract

The invention discloses a special medical application formula and a preparation method of a selenium-rich ginseng medicinal and edible herbal liquid, and belongs to the technical field of health foods and special medical foods. The formula is prepared from a selenium-enriched ginseng extract, Chinese yam powder, a poria cocos extract, a gordon euryale seed extract, a Chinese date extract, a longan aril extract and auxiliary materials through scientific compatibility, and has the effects of tonifying spleen and kidney, reinforcing qi and nourishing blood aiming at the pathogenesis of spleen and kidney deficiency and deficiency of qi and blood. According to the preparation method, a gradient process combining ultrasonic-assisted ethanol extraction and enzymolysis water extraction is adopted, and active ingredients such as organic selenium, ginseng rare saponin, jujube cAMP and longan polysaccharide are efficiently extracted and reserved. Experiments show that the herbal liquid has a remarkable synergistic effect in the aspects of improving immunity, improving hematopoietic function and resisting fatigue, and is suitable for nutrition support and function conditioning of tumor chemoradiotherapy patients and postoperative weak people.

Description

Technical Field

[0001] This invention belongs to the technical field of health food and special medical purpose formula food, specifically involving a special medical purpose formula and preparation method of a selenium-enriched ginseng medicinal and edible herbal liquid, which is particularly suitable for special medical purposes for cancer radiotherapy and chemotherapy patients, postoperative weak people and people with low immunity. Background Technology

[0002] Foods for Special Medical Purposes (FSMPs) are crucial for individuals with specific disease states. Selenium and ginseng are key trace elements and traditional tonic herbs, respectively, but current market products have significant limitations: single selenium supplements (such as selenium yeast) have poor bioavailability and limited functionality; ordinary ginseng products suffer from low rare saponin content, warming and drying properties, and low extraction efficiency using conventional methods; and existing FSMP formulations often focus on macronutrients or single herbal ingredients, lacking products that deeply integrate highly bioavailable selenium with scientifically formulated compound herbal systems that have multi-target regulatory effects. This lack of integration makes it difficult to provide synergistic and precise nutritional and functional support for complex states such as "immune exhaustion-energy metabolism disorder" after radiotherapy and chemotherapy. Furthermore, even among similar organic selenium raw materials, differences in their forms result in significant variations in bioavailability, metabolic pathways, and ultimate biological effects. For example, common selenium yeast mainly provides selenomethionine, while L-seleno-methylselenocysteine ​​(L-SeMC), as a highly efficient and safe active selenium precursor, shows unique advantages in anti-cancer and immune regulation. However, its innovative application in compound medical foods for specific debilitated populations has not yet been fully developed.

[0003] Therefore, developing a compound herbal liquid that combines high bioactive selenium, high-value ginsenosides, and multi-target synergistic conditioning effects has significant clinical demand and market value. Summary of the Invention

[0004] This invention aims to overcome the shortcomings of the prior art and provide a selenium-enriched ginseng herbal liquid with high bioavailability, significant synergistic effects, mild properties, and suitability for specific debilitated individuals, along with its efficient preparation method. To achieve the above objective, this invention adopts the following technical solution: In a first aspect, the present invention provides a selenium-enriched ginseng herbal liquid with special medicinal and edible uses, which is made from the following raw materials in parts by weight: 15-30 parts of selenium-enriched ginseng extract; 8-15 parts yam powder; 6-10 parts of Poria cocos extract; 8-15 parts of foxnut extract; Jujube extract, 10-20 parts; Longan pulp extract 5-15 parts; And pharmaceutically or food-grade excipients, including flavoring agents and pH adjusters.

[0005] Preferably, the selenium-enriched ginseng extract is an ethanol extract derived from ginseng grown in selenium-enriched soil for five years or more, with a root selenium content of 150–300 µg / 100g dry weight, of which organic selenium accounts for ≥85%.

[0006] Preferably, it further includes an efficacy enhancer, which is one or more of the following: vitamin C 1-5 parts, zinc gluconate 0.5-3 parts, fructooligosaccharides 2-10 parts, and L-seleno-methylselenocysteine ​​0.01-0.5 parts.

[0007] Preferably, the flavoring agent is xylitol, used in an amount of 3 to 15 parts; and the pH adjuster is sodium citrate, used in an amount of 0.1 to 1.0 parts.

[0008] The core concept and synergistic mechanism of this invention lies in using high-organic-selenium ginseng as the principal ingredient to greatly replenish vital energy, consolidate the body's foundation, and promote the production of body fluids, providing the core selenium element and saponin activity. It is combined with jujube and yam as assistant ingredients; jujube replenishes the middle energizer, invigorates qi, nourishes blood, and calms the mind, while yam invigorates the spleen and stomach, promotes the production of body fluids, benefits the lungs, and tonifies the kidneys and astringes essence. Together, they enhance the spleen-strengthening and qi-boosting effects. Euryale ferox is added to invigorate the kidneys, consolidate essence, strengthen the spleen, and stop diarrhea; longan pulp invigorates the heart and spleen, nourishes blood, and calms the mind; and Poria cocos promotes diuresis, eliminates dampness, strengthens the spleen, and calms the mind. The combined effects of these herbs are to strengthen the spleen and kidneys, invigorate qi and nourish blood, and calm the mind and stabilize the spirit. This combination is not a simple additive process, but rather a multi-target conditioning system addressing the core pathogenesis of "spleen and kidney deficiency and qi and blood depletion" commonly seen after surgery and radiotherapy / chemotherapy. Experiments have demonstrated that this combination produces significant synergistic effects in improving immune indicators, improving qi and blood status, and prolonging anti-fatigue time, far superior to formulas with single components or missing components.

[0009] Secondly, a method for preparing the above-mentioned herbal liquid for special medical purposes is provided, including the following steps: (1) Raw material pretreatment: Wash, dry and crush the selenium-enriched ginseng, poria cocos, euryale ferox, jujube and longan pulp; (2) Ultrasonic-assisted extraction: Mix the raw materials after step (1), add 10 to 15 times the amount of 50% to 70% ethanol solution, adjust the pH to 5.0 to 6.0, perform ultrasonic extraction, power 300 to 500W, temperature 50 to 60℃, extract 1 to 3 times, each time for 30 to 50 minutes, combine the extracts and centrifuge to obtain supernatant A; (3) Enzymatic hydrolysis and water extraction: Mix the dregs obtained in step (2) with yam powder, add 6 to 10 times the amount of water, add compound enzyme and hydrolyze at 40 to 50°C for 60 to 120 minutes, then heat to 85 to 95°C and reflux for 1 to 2 hours, and filter to obtain filtrate B; (4) Purification and concentration: Combine supernatant A and filtrate B, filter through a membrane and concentrate under vacuum at low temperature to obtain extract; (5) Preparation: Dissolve the extract, efficacy enhancer, flavoring agent, and pH adjuster in water, make up to volume, and stir evenly; (6) Sterilization and filling: The liquid is sterilized and then aseptically filled.

[0010] Preferably, in step (2), the ethanol concentration is 60%, the amount added is 12 times the amount, the ultrasonic power is 400W, the temperature is 55±2℃, and the extraction is performed twice, each time for 40 minutes; the compound enzyme in step (3) is composed of cellulase and pectinase in a mass ratio of 1:1, and the amount added is 0.1% to 0.3% of the total weight of the material.

[0011] Thirdly, the use of the above-mentioned herbal liquid in the preparation of special medical purpose formula foods for improving immune function, anti-fatigue and / or for nutritional support for patients undergoing radiotherapy and chemotherapy for tumors and for postoperative debilitated people is provided.

[0012] Compared with the prior art, the present invention has the following innovations, advantages and effects: 1. Strengthening the Spleen and Kidneys, Regulating Qi and Blood, with Significant Synergistic Effects: This invention scientifically formulates a formula based on the core pathological condition of "deficiency of both spleen and kidneys, and insufficiency of qi and blood" commonly encountered after surgery and radiotherapy / chemotherapy. Selenium-rich ginseng greatly replenishes vital energy; jujubes and yam strengthen the spleen, replenish qi, and nourish blood; fox nuts nourish the liver and kidneys; longan nourishes blood and calms the mind; and poria strengthens the spleen and calms the heart. These herbs work synergistically to construct a multi-target conditioning system covering "immunity-hematopoiesis-energy-nervous system." Experiments have demonstrated that this compound is significantly more effective than single-component formulas or similar commercially available products in improving immune organ indices, enhancing hemoglobin and red blood cell levels, and prolonging anti-fatigue time, achieving a synergistic effect of "1+1>2." In particular, the selectively added L-selenomethylselenocysteine ​​(L-SeMC) in the formula, as a highly bioavailable active selenium precursor, has metabolites that can synergize with rare saponins in selenium-enriched ginseng and other components, further enhancing its targeted effects in antioxidation, immune activation and cell protection. This is one of the key design points for achieving precise nutritional intervention in this program.

[0013] 2. Precise Nutritional Support, Balancing Heart and Spleen: This product is designed to address the complex state of "vital energy depletion and deficiency of both heart and spleen" caused by chemotherapy, radiotherapy, and postoperative recovery. It not only provides highly bioavailable organic selenium and rare ginseng saponins, but also, through a holistic approach using a formula derived from both food and medicine, simultaneously improves multiple issues such as weakened immune function, anemia, fatigue, palpitations, insomnia, and loss of appetite. It offers a comprehensive solution that combines nutritional supplementation with functional regulation for specific vulnerable individuals.

[0014] 3. Mild in nature, pleasant in taste, and highly compliant: The ingredients used in this formula are mostly medicinal and edible herbs. The combination of sweet and moistening ingredients such as jujube, longan, and yam makes the overall formula mild and nourishing without being drying. Furthermore, xylitol and fructooligosaccharides are used for flavoring and adjustment, giving the product a naturally sweet taste and avoiding sucrose intake, making it suitable for people who need to control their blood sugar. These design features significantly improve the product's safety and long-term patient compliance.

[0015] 4. Advanced technology, stable and controllable quality: Employing a gradient extraction process combining ultrasound-assisted ethanol extraction and enzymatic hydrolysis-water extraction, this technology maximizes the extraction and retention of heat-sensitive rare saponins, organic selenium, polysaccharides, cyclic adenosine monophosphate (cAMP), and other active ingredients, resulting in high extraction efficiency. Combined with standardized subsequent steps such as membrane filtration, low-temperature concentration, and UHT sterilization, this ensures the final product possesses advantages such as high active ingredient content, good stability, and strong batch-to-batch consistency. Attached Figure Description

[0016] Figure 1 This is a process flow diagram of the preparation method of the present invention. Detailed Implementation

[0017] The present invention will be further described below with reference to embodiments, but the scope of protection of the present invention is not limited thereto. In the following embodiments, unless otherwise specified, the methods described are conventional methods, and the raw materials are all commercially available. The selenium-enriched ginseng raw material meets the aforementioned requirements (selenium content 200µg / 100g dry weight, organic selenium content 90%). All extracts comply with the pharmacopoeia or relevant standards.

[0018] Example 1: The formula for the selenium-enriched ginseng medicinal and edible herbal liquid (lower limit of ratio) of the present invention is as follows: 15 parts selenium-enriched ginseng extract, 8 parts yam powder, 6 parts poria cocos extract, 8 parts euryale ferox extract, 10 parts jujube extract, 5 parts longan pulp extract, 2 parts vitamin C, 1 part zinc gluconate, 4 parts fructooligosaccharides, 5 parts xylitol, 0.3 parts sodium citrate, and purified water to a total of 1000 parts.

[0019] preparation: (1) Pretreatment: Wash the selenium-enriched ginseng, poria cocos, euryale ferox, jujube and longan pulp, dry them at 55℃, and pulverize them through 40 mesh and 20 mesh sieves respectively.

[0020] (2) Ultrasonic extraction: Mix the above-mentioned pulverized raw materials, add 12 times the amount of 60% ethanol, and adjust the pH to 5.5 with citric acid. Extract twice with ultrasound at 400W power and 55℃, 40 minutes each time. Combine the extracts and centrifuge at 4000rpm for 15 minutes to obtain supernatant A.

[0021] (3) Enzymatic hydrolysis and decoction: Mix the dregs with yam powder, add 8 times the amount of water, add 0.2% of compound enzyme (cellulase: pectinase = 1:1), and enzymatically hydrolyze at 45℃ for 90 minutes. Then heat to 90℃ and reflux for 1.5 hours, and filter to obtain filtrate B.

[0022] (4) Purification and concentration: Combine supernatant A and filtrate B and filter through a 0.22 μm ceramic membrane. The filtrate is concentrated under vacuum at 60 °C and -0.08 MPa to an extract with a relative density of 1.15 (60 °C).

[0023] (5) Preparation and filling: Transfer the extract to the preparation tank, add vitamin C and other excipients, dissolve in hot water at 70-80℃, add water to the total volume, and stir evenly. The liquid is sterilized at 137℃ for 5 seconds by UHT, cooled to below 25℃, and aseptically filled.

[0024] Example 2: The formula of this invention, a selenium-enriched ginseng medicinal and edible herbal liquid (optimal ratio): 25 parts selenium-enriched ginseng extract, 10 parts yam powder, 8 parts poria cocos extract, 12 parts euryale ferox extract, 15 parts jujube extract, 10 parts longan pulp extract, 3 parts vitamin C, 1.5 parts zinc gluconate, 5 parts fructooligosaccharides, 0.1 parts L-seleno-methylselenocysteine, 8 parts xylitol, 0.5 parts sodium citrate, and purified water to a total of 1000 parts.

[0025] The preparation method is the same as in Example 1.

[0026] Example 3: The formula for the selenium-enriched ginseng medicinal and edible herbal liquid of the present invention (upper limit of proportion): 30 parts selenium-enriched ginseng extract, 15 parts yam powder, 10 parts poria cocos extract, 15 parts euryale ferox extract, 20 parts jujube extract, 15 parts longan pulp extract, 4 parts vitamin C, 2 parts zinc gluconate, 8 parts fructooligosaccharides, 0.3 parts L-seleno-methylselenocysteine, 12 parts xylitol, 0.7 parts sodium citrate, and purified water to a total of 1000 parts.

[0027] The preparation method is the same as in Example 1.

[0028] Example 4 (Supporting an optional implementation of the efficacy enhancer in claim 3): formula: Based on Example 2, the efficacy enhancers were selected from only 8 parts of fructooligosaccharide and 0.2 parts of L-seleno-methylselenocysteine.

[0029] The preparation method is the same as in Example 1.

[0030] Comparative Example 1 The formula and preparation method are the same as in Example 2, except that the "selenium-enriched ginseng extract" is replaced with an equal amount of ordinary ginseng extract (selenium content <10µg / 100g).

[0031] Comparative Example 2 The formula and preparation method are the same as in Example 2, but without the addition of jujube extract.

[0032] Comparative Example 3 A commercially available brand of "Ginseng and Astragalus Oral Liquid" (not selenium-enriched, contains sucrose).

[0033] Comparative Example 4 The formula is the same as in Example 2, but the preparation method is changed to traditional water extraction: all raw materials (except for the excipients added later) are mixed, 10 times the amount of water is added, and the mixture is boiled at 100°C three times for 2 hours each time. The filtrates are combined and concentrated, and then the remaining excipients are added. The subsequent steps are the same.

[0034] Experimental Example: Product Testing and Effect Verification 1. Key component detection: The products of Example 2, Example 3 and comparative examples were tested, and the results are shown in the table below.

[0035] Table 1: Comparison of Key Active Ingredient Contents (Mean ± SD) ; Note: "-" indicates that it was not detected or the content was extremely low.

[0036] The results showed that the products of this invention (Examples 2 and 3) were significantly superior to Comparative Example 1 (ordinary ginseng) and Comparative Example 4 (traditional water extraction) in terms of total selenium content (342.5-370.8 µg / 100mL) and organic selenium ratio (≥88%). This advantage stems not only from the "selenium-enriched ginseng" raw material itself, but more importantly from the addition of "L-seleno-methylselenocysteine ​​(L-SeMC)" in the formulation. As a highly bioavailable organic selenium source that can be directly metabolized into active methylselenool, the trace addition of L-SeMC (0.1-0.3 parts) directly contributes to improving the total selenium level and organic selenium ratio of the final product, and this form of selenium has higher bioactivity and safety.

[0037] Meanwhile, the product of this invention also significantly exceeds the comparative ratio in the content of rare saponins (Rg3+Rh2), jujube cyclic adenosine monophosphate (cAMP), and longan polysaccharides, verifying the unique advantages of the gradient process of "ultrasound-assisted ethanol extraction combined with enzymatic hydrolysis and water extraction" in protecting heat-sensitive and water-soluble components. It is noteworthy that the high content of organic selenium (especially in the L-SeMC form) coexists with these rare ginseng saponins and plant active ingredients in the same system, laying a solid material foundation for the synergistic effect of multiple biological effects such as "antioxidant, immune activation, and hematopoietic promotion" observed in subsequent experiments. L-SeMC is not an isolated nutritional supplement, but a key functional component that forms a compound effect with the herbal active ingredients and enhances targeted regulatory effects.

[0038] 2. Animal in vitro functional experiments: Antioxidant capacity: The DPPH free radical scavenging rate was determined.

[0039] Immune cell and crude hematopoietic cell stimulation: Mouse macrophages RAW264.7 were treated with a concentration of 100 µg / mL, and the levels of NO and IL-6 secretion were detected; bone marrow mononuclear cells were treated, and the number of CFU-GM colonies was detected. The results are shown in the table below.

[0040] Table 2: Comparison of in vitro functional indicators (mean ± SD) ; Note: This indicates that P < 0.05 compared to Comparative Example 1.

[0041] A comparison of in vitro functional indicators (Table 2) shows that the products of this invention (Examples 2 and 3) exhibit superior DPPH free radical scavenging ability (IC50). 50 The product exhibited significantly superior activity compared to the control groups in terms of lower levels of ginseng, stimulation of immune cells (RAW264.7) to secrete NO and IL-6, and promotion of crude hematopoietic cells (CFU-GM) colony formation (P<0.05). This excellent in vitro activity is closely related to the active ingredient group rich in the product, with L-SeMC and high organic selenium ginsenosides as the core. As a highly efficient active selenium precursor, L-SeMC's potential rapid antioxidant and immunomodulatory mechanisms complement the effects of ginsenosides, jujube cAMP, etc., together constituting the source of the synergistic advantage in in vitro function.

[0042] 3. Animal in vivo functional experiments Experimental Design: Healthy ICR mice were randomly divided into: normal control group, model group, medium-dose group of Example 2 (5 mL / kg·d), Example 3 group, Example 4 group, and comparative groups 1-4 (equal volume 5 mL / kg·d). Except for the normal group, the other groups were given intraperitoneal injection of cyclophosphamide combined with restricted feeding to establish a composite model of "spleen and kidney deficiency and qi and blood insufficiency", and were administered the drug by gavage for 14 days.

[0043] Table 3: Comparison of core indicators of the composite model (mean ± SD, n=10) ; Note: Compared with the model control group, P<0.05, *P<0.01.

[0044] In vivo experiments on the compound model mice (Table 3) further confirmed that the groups of the present invention (Examples 2, 3, and 4) were significantly better than the model group and all comparative groups in terms of restoring the thymus / spleen index, increasing the hemoglobin / serum total protein level, and prolonging the weight-bearing swimming time (P<0.01). Among them, Examples 2 and 3 (containing L-SeMC) showed a better trend in the degree of recovery of multiple indicators than Comparative Examples 1 and 4, which did not contain L-SeMC or contained ordinary selenium sources. This initially confirms the positive role of L-SeMC in enhancing the "spleen-tonifying and kidney-tonifying, qi-nourishing and blood-nourishing" effects of the overall compound.

[0045] The above test and experimental data together show that: 1. This invention successfully prepared a herbal liquid with significantly higher content of key active ingredients (especially highly bioavailable organic selenium, rare saponins, cAMP, and polysaccharides) by using a specific combination of selenium-rich raw materials (core containing L-SeMC) and an advanced gradient extraction process.

[0046] 2. The presence of L-selenomethylselenocysteine ​​(L-SeMC) in the product is crucial. It is not only key to achieving high organic selenium content and high selenium bioavailability, but also, as a highly efficient bioactive selenium precursor, synergistically works with other active ingredients such as selenium-enriched ginseng rare saponins, jujube cAMP, and longan polysaccharides to jointly drive the product's remarkable in vitro and in vivo efficacy in terms of antioxidation, immune regulation, hematopoietic promotion, and overall anti-fatigue.

[0047] 3. The effects of Comparative Example 1 (ordinary ginseng with extremely low selenium content) and Comparative Example 4 (traditional process, which destroys heat-sensitive components) were significantly inferior to the embodiments of the present invention. This proves that both "selenium-rich raw materials (designed to contain L-SeMC)" and "specific process" are indispensable. In particular, L-SeMC, as a designed addition of highly active selenium form, cannot be replaced by simply increasing the amount of ordinary ginseng or changing the extraction method. Its addition makes this formula transcend the scope of traditional tonic compound formulas or ordinary selenium supplements, becoming a special medical purpose formula food that targets the core pathology of "spleen and kidney deficiency and insufficient qi and blood," while also providing precise nutritional support and multi-target functional regulation.

[0048] Secondly, the experimental data above also fully demonstrate that the compound herbal liquid provided by this invention, with selenium-enriched ginseng, jujube, longan, and gorgon fruit as its core ingredients, is significantly superior to ordinary raw material products, formulas with missing components, commercially available products, or products made using traditional processes in terms of the content of key active ingredients, in vitro functions, and in vivo improvement effects on weakness. This reflects the outstanding advantages of this invention in terms of scientific formulation, advanced process, and special medical value.

[0049] The specific combination of raw materials and their proportions provided by this invention produce synergistic effects that cannot be achieved by using the components individually or in simple combinations. This demonstrates the non-obviousness of the technical solution of this invention, which cannot be easily obtained by those skilled in the art through conventional experiments.

[0050] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention shall be considered equivalent substitutions and shall be included within the protection scope of the present invention.

Claims

1. A special medical formula for a selenium-enriched ginseng medicinal and edible herbal liquid, characterized in that: Made from the following parts by weight of raw materials: 15-30 parts of selenium-enriched ginseng extract; 8-15 parts yam powder; 6-10 parts of Poria cocos extract; 8-15 parts of foxnut extract; Jujube extract, 10-20 parts; Longan pulp extract 5-15 parts; And pharmaceutically or food-grade excipients, including flavoring agents and pH adjusters.

2. The selenium-enriched ginseng medicinal and edible herbal liquid according to claim 1, characterized in that: The selenium-enriched ginseng extract is an ethanol extract derived from ginseng grown in selenium-enriched soil for five years or more, with a root selenium content of 150–300 µg / 100g dry weight, of which organic selenium accounts for ≥85%.

3. The selenium-enriched ginseng medicinal and edible herbal liquid according to claim 1 or 2, characterized in that: It also contains an efficacy enhancer, which is one or more of the following: vitamin C 1-5 parts, zinc gluconate 0.5-3 parts, fructooligosaccharides 2-10 parts, and L-seleno-methylselenocysteine ​​0.01-0.5 parts.

4. The selenium-enriched ginseng medicinal and edible herbal liquid according to claim 1, characterized in that: The flavoring agent is xylitol, used in an amount of 3 to 15 parts; the pH adjuster is sodium citrate, used in an amount of 0.1 to 1.0 parts.

5. The selenium-enriched ginseng medicinal and edible herbal liquid according to any one of claims 1-4, characterized in that: The herbal liquid contains a total selenium content of 300-385µg / 100mL, of which organic selenium accounts for ≥85%; the total ginsenoside content is not less than 300mg / 100mL, and the total content of rare saponins Rg3 and Rh2 is not less than 20mg / 100mL.

6. The selenium-enriched ginseng medicinal and edible herbal liquid according to claim 5, characterized in that: The herbal liquid also contains 3.0-8.0 mg / 100 mL of jujube cyclic adenosine monophosphate (cAMP) and 10-30 mg / 100 mL of longan polysaccharide.

7. A method for preparing the selenium-enriched ginseng medicinal and edible herbal liquid as described in any one of claims 1 to 6, characterized in that: Includes the following steps: (1) Raw material pretreatment: Wash, dry and crush the selenium-enriched ginseng, poria cocos, euryale ferox, jujube and longan pulp; (2) Ultrasonic-assisted extraction: Mix the raw materials after step (1), add 10 to 15 times the amount of 50% to 70% ethanol solution, adjust the pH to 5.0 to 6.0, perform ultrasonic extraction, power 300 to 500W, temperature 50 to 60℃, extract 1 to 3 times, each time for 30 to 50 minutes, combine the extracts and centrifuge to obtain supernatant A; (3) Enzymatic hydrolysis and water extraction: Mix the dregs obtained in step (2) with yam powder, add 6 to 10 times the amount of water, add compound enzyme and hydrolyze at 40 to 50°C for 60 to 120 minutes, then heat to 85 to 95°C and reflux for 1 to 2 hours, and filter to obtain filtrate B; (4) Purification and concentration: Combine supernatant A and filtrate B, filter through a membrane and concentrate under vacuum at low temperature to obtain extract; (5) Preparation: Dissolve the extract, efficacy enhancer, flavoring agent, and pH adjuster in water, make up to volume, and stir evenly; (6) Sterilization and filling: The liquid is sterilized and then aseptically filled.

8. The method according to claim 7, characterized in that: In step (2), the ethanol concentration is 60%, the amount added is 12 times the amount, the ultrasonic power is 400W, the temperature is 55±2℃, and the extraction is performed twice, each time for 40 minutes; in step (3), the compound enzyme is composed of cellulase and pectinase in a mass ratio of 1:1, and the amount added is 0.1% to 0.3% of the total weight of the material; in step (4), the membrane filtration uses a 0.22μm ceramic membrane.

9. The use of the selenium-enriched ginseng medicinal and edible herbal liquid according to any one of claims 1 to 6 in the preparation of special medical purpose formula foods for improving immune function, anti-fatigue and / or for nutritional support for patients undergoing radiotherapy and chemotherapy for tumors and for postoperative debilitated people.

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