Traditional Chinese medicine composition for treating acne and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating acne. The traditional Chinese medicine composition is prepared from fourteen medicinal materials including platycodon grandiflorum, thunberg fritillary bulb, semen armeniacae amarae, pericarpium citri reticulatae, rhizoma pinelliae preparata, liquorice, poria cocos, radix paeoniae alba, radix bupleuri, moutan bark, radix rehmanniae recen, radix scrophulariae, duckweed and scutellaria baicalensis. According to the treatment principle of astringing ministerial fire, descending stomach meridian and dispersing stagnated heat, radix scrophulariae and rhizoma pinelliae preparata are matched to guide fire to origin and astringe floating fire; radix paeoniae alba, radix bupleuri and the like can soothe liver, strengthen spleen and help stomach channel descending; duckweed is matched with platycodon grandiflorum and semen armeniacae amarae to form an ascending and descending diffusing power, so that deep heat toxin permeates from inside to outside. According to clinical observation of 120 Pilsbury III-IV-level intractable acne patients, the total effective rate is 97.5%, the obvious effective rate is 91.7%, the Pilsbury III-IV-level intractable acne composition takes effect in 3-5 days on average, the nodule fading rate is 92.3% on average, the recurrence rate is only 2.5% in 6 months, the scar improvement rate is 85.0%, and the occurrence rate of menstrual disorder of female patients is 0%. A contrast experiment further proves that the nodule fading rate is only 58.7% after the duckweed, the platycodon grandiflorum and the semen armeniacae amarae are removed. The traditional Chinese medicine composition can rapidly fade red and swollen nodules, thoroughly expel heat toxins, protect healthy qi, reduce relapse and scar formation, and overcome the defects that a traditional bitter cold heat clearing prescription is prone to causing'ice-over-evil ', hurt healthy qi and menstrual disorder.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and relates to an oral Chinese medicine composition for treating acne vulgaris and refractory nodular acne, and its preparation method. Background Technology

[0002] Acne is a chronic inflammatory disease of the pilosebaceous unit, especially severe nodular acne, which is persistent, difficult to cure, and prone to scarring. Current traditional Chinese medicine treatments mainly focus on clearing heat and detoxifying, cooling the blood and dispersing blood stasis. While these methods have some clinical efficacy, the large amounts of bitter and cold herbs can easily lead to "suppressing the pathogenic factors," meaning the heat is suppressed deep within the skin, obstructing the flow of qi and blood, and making it difficult to completely expel toxins, manifesting as stubborn nodules and recurring inflammation. Long-term use of bitter and cold herbs can also damage the spleen and stomach's yang qi, commonly causing menstrual irregularities, worsened dysmenorrhea, and increased blood clots in female patients. Post-treatment, pigmentation or atrophic scars are also common, severely impacting patients' quality of life. Currently, there is still a lack of a comprehensive treatment plan that can both expel pathogenic factors and restore the normal flow of qi without harming the body's vital energy. Summary of the Invention

[0003] Purpose of the invention The purpose of this invention is to provide a traditional Chinese medicine composition for treating acne, which can quickly reduce skin lesions, lower the recurrence rate, improve scars, protect the body's vital energy, and avoid side effects such as abnormal menstruation in women.

[0004] Technical solution The traditional Chinese medicine composition of the present invention is made from the following raw materials in parts by weight: Platycodon grandiflorus 5-15 parts, Fritillaria thunbergii 10-15 parts, Prunus armeniaca 5-10 parts, Citrus reticulata 6-12 parts, Pinellia ternata 6-15 parts, Glycyrrhiza uralensis 3-10 parts, Poria cocos 10-25 parts, Paeonia lactiflora 10-20 parts, Bupleurum chinense 6-15 parts, Paeonia suffruticosa 10-15 parts, Rehmannia glutinosa 10-20 parts, Scrophularia ningpoensis 10-20 parts, Spirodela polyrhiza 5-15 parts, and Scutellaria baicalensis 10-20 parts. The preferred formula is: 10 parts Platycodon grandiflorus, 10 parts Fritillaria thunbergii, 8 parts bitter apricot kernel, 10 parts dried tangerine peel, 10 parts Pinellia ternata, 5 parts licorice, 15 parts Poria cocos, 12 parts white peony root, 10 parts Bupleurum chinense, 12 parts Paeonia suffruticosa, 15 parts Rehmannia glutinosa, 15 parts Scrophularia ningpoensis, 10 parts Spirodela polyrhiza, and 15 parts Scutellaria baicalensis.

[0005] Pharmacological mechanisms and beneficial effects This invention establishes a treatment approach of "constraining the ministerial fire, regulating the stomach meridian, and dispersing stagnant heat," thereby restoring the balance of Qi. (1) To astringe the ministerial fire and guide the fire back to its source: Scrophularia nourishes yin and clears metal, promotes diuresis and reduces fire, providing a way for the fire evil to descend; Pinellia clears phlegm and descends rebellious qi, astringes floating fire. The combination of the two drugs allows the upward flaring fire to return to its proper place, quickly relieving facial redness, swelling and nodule pain. (2) Smoothing down the stomach meridian and restoring Qi: Acne often occurs along the Yangming stomach meridian. This formula uses white peony to nourish blood and soften the liver, bupleurum to soothe the liver and raise Yang, tangerine peel to regulate Qi and strengthen the spleen, and poria to drain dampness and strengthen the spleen. The synergistic effect promotes the smooth flow of Qi in the stomach meridian, fundamentally eliminating the internal driving force for recurring acne. (3) Disperse and release stagnant heat from the inside out: Duckweed is pungent and cool, and floats lightly, which can open the closed door of the skin; combined with Platycodon grandiflorus to promote lung function and promote qi, and bitter apricot kernel to lower qi and moisten the intestines, the rising and falling forms a highly efficient "dispersing and lowering power", which allows the deep heat toxins to be released outwards in a natural way, and completely solves the problem of toxins trapped inside caused by the "ice-suppressing evil" of bitter and cold drugs. (4) The whole formula uses both cold and warm properties to protect the body's vital energy: the whole formula clears heat without being too bitter and cold, and disperses without harming yin. No side effects such as menstrual abnormalities have been observed in clinical practice, and it significantly promotes scar repair. Detailed Implementation

[0006] Example 1 (Optimal Ratio): Platycodon grandiflorus 10g, Fritillaria thunbergii 10g, Prunus armeniaca 8g, Citrus reticulata 10g, Pinellia ternata 10g, Glycyrrhiza uralensis 5g, Poria cocos 15g, Paeonia lactiflora 12g, Bupleurum chinense 10g, Paeonia suffruticosa 12g, Rehmannia glutinosa 15g, Scrophularia ningpoensis 15g, Spirodela polyrhiza 10g, Scutellaria baicalensis 15g.

[0007] Example 2 (Proportional Floating Example): Platycodon grandiflorus 12g, Fritillaria thunbergii 12g, Prunus armeniaca 7g, Citrus reticulata 8g, Pinellia ternata 12g, Glycyrrhiza uralensis 4g, Poria cocos 20g, Paeonia lactiflora 15g, Bupleurum chinense 8g, Paeonia suffruticosa 12g, Rehmannia glutinosa 18g, Scrophularia ningpoensis 12g, Spirodela polyrhiza 12g, Scutellaria baicalensis 18g.

[0008] Preparation method: (1) Wash the medicinal materials. Fritillaria thunbergii and Paeonia suffruticosa can be lightly crushed. Soak them in 8-10 times the amount of water for 40-60 minutes. (2) Bring to a boil over high heat, then simmer over low heat for 45-50 minutes, and filter out the first decoction; (3) Add 6-8 times the amount of water to the dregs and decoct again for 30-40 minutes, then filter out the second decoction; (4) Combine the medicine and take it warm in the morning and evening, one dose per day; (5) Alternatively, the combined drug solution can be vacuum concentrated to a relative density of 1.15-1.25 (measured at 60℃), and excipients can be added to make granules, capsules, tablets, etc. Typical cases

[0009] Case 1: Patient Wang, male, 21 years old, had nodular acne on his face for more than 4 years. His cheeks were dark red with hard nodules, and he experienced significant tenderness. His tongue was red with a yellow, greasy coating. Previous treatments with traditional Chinese medicine for clearing heat and detoxifying had been ineffective. After taking this formula for 3 doses, the tension of the nodules decreased and the pain was significantly relieved. After taking 14 doses consecutively, the nodules had basically disappeared by more than 90%. During a six-month follow-up, no new nodules appeared, and his skin remained smooth.

[0010] Case 2: Patient Zhao, female, 25 years old, presented with recurrent facial pustules and dysmenorrhea. She had previously experienced scanty, dark-colored menstrual flow with clots after taking bitter and cold Chinese medicine. After two courses of treatment with this formula, the skin lesions largely subsided, and her menstrual flow returned to normal, abdominal pain disappeared, and her menstrual blood turned bright red. Clinical observation

[0011] 120 patients with Pillsbury grade III–IV refractory acne were randomly divided into a treatment group (the decoction of this invention) and a control group (Forsythia suspensa antidote pills). The treatment course was 4 weeks, and the patients were followed up for 6 months. Results: The treatment group showed a significant efficacy rate of 91.7% (skin lesion regression ≥90%, no new rashes), and a total effective rate of 97.5% (skin lesion regression ≥60%). The average time to see results was 3–5 days. The average nodule regression rate was 92.3% (compared to 56.8% in the control group). The 6-month recurrence rate was 2.5% (compared to 21.3% in the control group). The scar improvement rate was 85.0% (compared to 43.8% in the control group). The incidence of menstrual abnormalities in female patients was 0% (compared to 18.3% in the control group). To further verify the necessity of the mechanism of clearing heat and stagnation, a comparative experiment with 40 cases of reduced ingredients was conducted: the control group had duckweed, platycodon, and bitter almond removed (the rest remained the same). The results showed that the nodule regression rate in the treatment group was 92.3%, and the average time to relieve redness and swelling was 3.8 days; the reduced ingredients in the control group were only 58.7% and 9.6 days, respectively. This experiment strongly demonstrates that the clearing and guiding effects of duckweed, platycodon, and bitter almond produce a significant synergistic effect, rather than a simple drug additive effect. in conclusion

[0012] This invention, through its unique formulation and meridian-guiding mechanism, achieves the simultaneous elimination of pathogens, thorough detoxification, and protection of vital energy. It has definite clinical efficacy and good safety, and is significantly superior to existing bitter and cold heat-clearing regimens. It solves clinical problems such as "suppressing pathogens with ice," easy recurrence, scarring, and damage to vital energy, and has outstanding substantive features and significant progress.

Claims

1. A traditional Chinese medicine composition for treating acne, characterized in that, It is prepared from the following raw materials in parts by weight: Platycodon grandiflorus 5–15 parts, Fritillaria thunbergii 10–15 parts, Prunus armeniaca 5–10 parts, Citrus reticulata 6–12 parts, Pinellia ternata 6–15 parts, Glycyrrhiza uralensis 3–10 parts, Poria cocos 10–25 parts, Paeonia lactiflora 10–20 parts, Bupleurum chinense 6–15 parts, Paeonia suffruticosa 10–15 parts, Rehmannia glutinosa 10–20 parts, Scrophularia ningpoensis 10–20 parts, Spirodela polyrhiza 5–15 parts, and Scutellaria baicalensis 10–20 parts.

2. The traditional Chinese medicine composition for treating acne according to claim 1, characterized in that, The preferred weight proportions of each raw material are as follows: Platycodon grandiflorus 10 parts, Fritillaria thunbergii 10 parts, Prunus armeniaca 8 parts, Citrus reticulata 10 parts, Pinellia ternata 10 parts, Glycyrrhiza uralensis 5 parts, Poria cocos 15 parts, Paeonia lactiflora 12 parts, Bupleurum chinense 10 parts, Paeonia suffruticosa 12 parts, Rehmannia glutinosa 15 parts, Scrophularia ningpoensis 15 parts, Spirodela polyrhiza 10 parts, and Scutellaria baicalensis 15 parts.

3. A traditional Chinese medicine composition for treating acne according to claim 1 or 2, characterized in that, In the raw materials, the weight ratio of Scrophularia ningpoensis to Pinellia ternata is 1.25:1 to 1.5:1; the weight ratio of Spirodela polyrhiza to Platycodon grandiflorus is (0.8-1.2):1; and the weight ratio of Platycodon grandiflorus to Prunus armeniaca is 1:(0.8-1).

4. A method for preparing a traditional Chinese medicine composition for treating acne according to any one of claims 1-3, characterized in that, Includes the following steps: (1) Pretreatment of medicinal materials: Wash all raw materials. Fritillaria thunbergii and Paeonia suffruticosa can be lightly crushed mechanically to facilitate the dissolution of active ingredients; (2) Soaking and extraction: Soak the herbs in drinking water at a volume of 8-10 times their total weight for 40-60 minutes; (3) First decoction: After boiling over high heat, simmer over low heat for 45-50 minutes, then filter out the first decoction; (4) Second decoction: Add 6-8 times the amount of water to the dregs and simmer over low heat for 30-40 minutes. Filter out the second decoction. (5) Concentration and molding: Combine the two liquids and take them warm in the morning and evening, one dose per day; or concentrate them under vacuum at 65-75℃ to a relative density of 1.15-1.25 (measured at 60℃) and add pharmaceutically acceptable excipients to make oral decoctions, granules, capsules, pills or tablets.

5. The use of the traditional Chinese medicine composition for treating acne according to any one of claims 1-4 in the preparation of a drug for treating refractory acne, nodular acne, or improving the constitution prone to acne recurrence and reducing the recurrence rate of acne, characterized in that: The medicine achieves smooth Qi flow by astringing the fire of the heart, regulating the stomach meridian, and dispelling stagnant heat. It does not harm the body's vital energy during treatment and does not cause side effects during menstruation in women.