Flavonoid compound in lomatogonium radiatum as well as preparation method and application of flavonoid compound

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By isolating and purifying flavonoids from Pterocarya radiata, the problem of insufficient research on their pharmacologically active substances in existing technologies has been solved, enabling the preparation of compounds with anti-inflammatory activity suitable for anti-inflammatory drugs.

CN121736028APending Publication Date: 2026-03-27JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1

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Patent Information

Application Number: CN202610230686.6
Authority / Receiving Office: CN · China
Patent Type: Applications(China)
Current Assignee / Owner
Filing Date: 2026-02-27
Publication Date: 2026-03-27

Application Information

Patent Timeline

27 Feb 2026

Application

CN202610230686.6

27 Mar 2026

Publication

CN121736028A

IPC: C07H17/04; C07H1/08; A61K31/7048; A61P29/00

CPC: Y02A50/30

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Application Domain

Organic active ingredients Sugar derivatives

Technology Topics

Medicinal herbs Pharmaceutical Substances

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AI Technical Summary

Technical Problem

Current technology has limited research on the medicinal substances of Radial Ribaceous Flower, lacking effective anti-inflammatory drug components, making it difficult to fully utilize its medicinal potential.

Method used

Flavonoids were isolated and purified from *Stylocarpa radiata* through ethanol extraction, column chromatography, and semi-preparative high-performance liquid chromatography, resulting in compounds with anti-inflammatory activity.

Benefits of technology

The obtained flavonoids significantly inhibited the levels of COX2, IL-6 and TNF-α in mouse macrophages, showing significant anti-inflammatory activity and are suitable for the preparation of anti-inflammatory drugs.

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Abstract

The invention belongs to the technical field of natural pharmaceutical chemistry, and discloses a flavonoid compound in lomatogonium radiatum as well as a preparation method and application thereof.The flavonoid compound is separated from lomatogonium radiatum of a gentiaceae lomatogonium plant, the medicinal material of lomatogonium radiatum is extracted and concentrated, and the flavonoid compound is obtained. And sequentially carrying out macroporous adsorption resin separation, gel column chromatography separation, medium-low pressure ODS column chromatography separation and semi-preparative high performance liquid chromatography separation. Pharmacological studies show that the compound provided by the invention can effectively inhibit the levels of COX2, IL-6 and TNF-alpha in mouse macrophages RAW246.7 caused by lipopolysaccharide (LPS), which indicates that the compound has obvious anti-inflammatory activity and can be used for preparing anti-inflammatory drugs.

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