88 results about "Design synthesis" patented technology

The invention discloses a method for preparing ziconotide. The technical scheme of the invention comprises the following steps: (1) obtaining an Fmoc-Cys(Acm)-amino resin from Fmoc-Cys(Acm)-OH and an amino resin; (2) obtaining a linear-ziconotide-amino resin of which a Cys side chain comprises Acm by performing the solid phase synthesis on the Fmoc-Cys(Acm)-amino resin and an amino acid adopting Fmoc group protection; (3) obtaining a linear crude peptide of which the Cys side chain comprises the Acm by performing cracking on the linear-ziconotide-amino resin of which the Cys side chain comprises the Acm, and obtaining linear ziconotide by removing the Acm, purifying and freeze-drying; (4) and obtaining the ziconotide by performing cyclization, purifying and freeze-drying on the linear ziconotide. The method for preparing ziconotide has the characteristics of simple reaction operation, easy subsequent treatment, low raw material investment, low cost, high yield and the like, and has considerable economic and practical value, and also has wide application prospect in the field of design synthesis of polypeptide drugs.

The invention relates to a preparation method and an application for nitrogen phosphorus co-doped porous carbon. A precursor copolymer is self-assembled through a one-step method; and high-temperature roasting is performed to prepare the nitrogen phosphorus co-doped porous carbon. A prepared catalyst material is obvious in porous structure and large in specific surface area; and more catalytic active sites are exposed, so that the electro-catalysis oxygen reduction activity can be improved. The preparation method for performing precursor copolymerization by using simple weak interaction to further synthesize a material with a certain morphology is simple in step and easy in operation; and a synthesis mechanism of the preparation method has an important enlightening effect for large-scale design synthesis of a nanometer material in the future and application of the material to the research of the fields of electro-catalysis, supercapacitors, adsorption separation and the like.

The invention discloses a symmetric benzimidazole ruthenium complex and its preparation method and belongs to the technical field of synthetic chemistry. According to the preparation method, 2,4,6-trismesitylene and triethyl phosphate are used as starting materials, a fixed ligand is synthesized by a two-step method, and the fixed ligand finally reacts with ruthenium trihydrate under the microwave condition so as to synthesize the target product. The synthesized symmetric benzimidazole ruthenium complex has excellent stability and optical and electrochemical properties. Through covalent bond effect between symmetric phosphate groups at two ends of the molecule and the surface of a conductive substrate such as ITO and the like, the symmetric benzimidazole ruthenium complex molecule is fixed to the conductive substrate and layer-by-layer self-assembly is realized. The symmetric benzimidazole ruthenium complex is an excellent photosensitizer. In addition, the designed synthesis process of the symmetric benzimidazole ruthenium complex is simple, costs are low, and the microwave-assisted synthesis technology is rapid and efficient.

A method (100) for cascading system level target to component level design objectives using machine learning and design synthesis techniques. The method (100) of the present invention uses machine learning techniques to build (106, 108) surrogate models from given system targets (102). The method then employs design synthesis methods to determine (110) a range of component level design objectives for the given system level targets using the surrogate models. The range of component level design objectives is fed back (112) to one of the surrogate models to determine (114) the component design objectives.

The invention provides an aircraft nose wheel steering control box design method based on a graphical model. The model-based design method adopts a model to describe a system. The method performs simulation and analysis of system theories and functions before product manufacturing through three steps of demand analysis, function analysis and design integration, and thus system features are fully and precisely mastered, thereby reducing development iteration frequency, reducing cost, shortening period, improving design quality and improving development frequency.

Methods and apparatuses to automatically determine conditions at hierarchical boundaries of a hierarchical circuit design and to use the determined conditions in hierarchical optimization and verification. In one embodiment, a hierarchical block is optimized and transformed during design synthesis using one or more lemmas at the boundary of the hierarchical block. For example, the lemmas are automatically generated to specify range information for input boundary nodes. The lemmas are also used for the equivalence checker to perform hierarchical equivalence checking. Equivalence of hierarchical blocks is individually checked, in view of the lemmas. Thus, based on the lemmas, optimizations across hierarchical boundaries can be performed, while the hierarchical structure of the design is preserved so that equivalence checking of hierarchical circuit designs can still be based on the equivalence of individual hierarchical blocks.

An integrated circuit design library includes a timing parameter representative of a design element in an integrated circuit; an area size parameter representative of the design element in an integrated circuit; and a routing demand parameter representative of a number of connections required for the design element for each value of the timing parameter and the area size parameter.

The invention discloses a novel method for preparing solithromycin. Compared with the conventional solithromycin preparation process, a designed synthesis process adopted by the novel method has the advantages that the occurrences of side reactions are effectively reduced, the dangerous and toxic operating steps are avoided, and the reaction conversion rate is improved, so that the production cost is reduced, and the novel method is suitable for industrialized production.

The invention provides xanthone fluorochrome and application therefore to design synthesis of a fluorescence probe. The Xanthone fluorochrome has the following structure general formulas I, II, III and IV shown in the description, wherein R1, R2, R3 and R4 are respectively selected from hydrogen, halogen, hydroxyl, NH2, sulfydryl, cyano-group, nitryl, N,N-bis-C1-4 alkyl amino group, aldehyde group, carboxyl, amido, sulfoamido, C5-10 aryl, C2-8 heterocyclic aryl, C1-6 alkyl, boric acid, boronic acid pinacol ester and OR (wherein R is C1-4 saturated alkyls or unsaturated alkyls).

The invention belongs to the technical field of synthesis of organic-inorganic hybrid materials and relates to an electron transfer type hybrid photochromic material and a preparation method thereof.The method comprises the following steps: uniformly mixing oxalic acid, a metal source, TPT, a phosphorus source and DMF or DMAc to obtain a mixture, loading the mixture to a stainless steel high-pressure reaction container provided with a polytetrafluoroethylene reactor and crystallizing the mixture at 145 DEG C for 7-8 days to obtain blocky colorless or grey violet crystals with good crystallinity; performing deionized water washing and suction filtration on the crystals sequentially, and performing drying at room temperature to obtain the electron transfer type hybrid photochromic material.The prepared material is novel in structure, the preparation process is simple and convenient to operate, and reference is provided for design synthesis and application research of the electron transfer type hybrid photochromic material.

The present invented method includes determining design synthesis coefficient Ak, determining steam turbine noumenal availability AP 1, determining steam turbine autocontrol subsystem availability AP 2, determining steam turbine oil servicing and lubricating oil subsystem availability AP 3, determining steam turbine heat engineering monitor and protected subsystem availability AP 4, determining steam turbine vapour lock and dewatering subsystem availability AP 5, determining steam turbine scheduled outage coefficient POF, calculating steam turbine availability coefficient AF, finally evaluating result, only scheme turnaround year steam turbine availability coefficient AF >= 0.92 and steam turbine designed usability reaching fineness value, otherwise to proceed improved design until turnaround year steam turbine availability coefficient availability coefficient AF >= 0.92 and reaching fineness value. Said invention has advantages of in design stage capable of quantitative calculating, quantitative evaluation and effectively raising steam turbine availability coefficient.

The present invention relates to a graphical user interface for a system that complies MATLAB models for synthesis into register transfer level code. The graphical user interface provides a visual representation of the design in a manner that allows the user to more easily understand the algorithm being modeled. From this interface, the user may also modify the type, size and dimensions of variables from dialog boxes. The system allows the user to efficiently compare and verify a fixed-point design versus the MATLAB design. The interface allows the user to then make further changes to the design, or synthesize the design into a register transfer level file.

A method and system for tiling a bias design for an integrated circuit device to facilitate efficient design rule checking. The method is implemented in a computer implemented design synthesis system. The method includes receiving a circuit netlist, wherein the circuit netlist represents an integrated circuit design to be realized in physical form. A deep N-well bias voltage distribution structure is provided within the circuit netlist, wherein the structure includes a plurality of tiles arranged to distribute a bias voltage to a plurality of N-wells of the circuit netlist.

The invention discloses an in-vitro screening method for antineoplastic activity of artemisinin and derivatives of the artemisinin. The method comprises the following steps: analyzing the interaction between the artemisinin or the derivatives of the artemisinin and transferrin by adopting ultraviolet-visible absorption spectra or fluorescence spectra; calculating the combining factor Kb of the artemisinin or the derivatives of the artemisinin and the transferring; comparing the combining factor Kb of the artemisinin or the derivatives of the artemisinin and the transferring, or sequencing according to the combining factor Kb, and inferring the strength sequence of the antineoplastic activity of the artemisinin or the derivatives of the artemisinin; and verifying screening results by adopting antineoplastic activity tests. According to the method, a spectroscopic method is used for detecting the combining factor Kb of the artemisinin or the derivatives of the artemisinin and the transferring, and the in-vitro screening is carried out on the antineoplastic activity of the artemisinin and the derivatives of the artemisinin according to the sequence of the combining factor Kb. By using the method, the antineoplastic activity of the derivatives of the artemisinin can be fast and effectively judged, the method can be used for providing the base for designed synthesis of artemisinin-based drugs and clinical application of the artemisinin-based drugs, and promoting the application of the artemisinin-based drugs in the antineoplastic field.

The invention discloses an asymmetric synthesis method of a gamma-alkenyl substituted butenolide or butenolactam compound. The method adopts cheap nickel to catalyze a [3+2] asymmetric cycloaddition reaction of a cyclopropenone compound and alpha, beta-unsaturated ketone or imine, the selective insertion reaction of intermolecular C=X after nickel-catalyzed C-C bond activation is realized for thefirst time, wherein X is equal to O or N, the gamma-alkenyl substituted butenolide or butenolactam compound is obtained in a high yield, high enantioselectivity and chirality controllable manner, thesynthesis method is novel, condition mildness, substrate with good applicability, simple and efficient reaction, cheap and readily available catalyst, according to the present invention, the synthesisprocess is simple, the atom economy is good, the synthesis product is easy to derivatize, the method can be widely used in completely-synthesized designed synthesis building blocks and new chiral drug derivatives, and the ligand compound is further provided, and can be used for the asymmetric synthesis of gamma-alkenyl substituted butenolide or butenolactam compounds.

The invention discloses a method for designing and synthesizing anti-PCV shRNA. The method comprises the steps of: 1) selecting a section of nucleotide sequence with length of 19bp according to genomesequence of PCV-2 and by taking Rep gene or Cap gene as target gene; 2) selecting a nucleotide sequence as a candidate nucleotide sequence, which meets the following three conditions: GC content of the nucleotide sequence is between 40 percent and 60 percent; at least three A or T nucleic-acid residues exist among locus from 15 to 10; and secondary structure is ensured not to be generated by 19bpnucleotide sequence after inspection; and 3) comparing the obtained candidate nucleotide sequence with PCV genome so as to determine whether the candidate nucleotide sequence only specially aims at the target gene. The anti-PCV shRNA provided by the invention can play the anti-virus role by restricting reproduction of PCV in cells.

The invention provides a human interleukin29 mature peptide mutant (hIL-29Z) with arginine and lysine produced respectively by site-directed mutagenesis of 33th lysine and 35th arginine and a preparation method thereof. The preparation method comprises the following steps of 1, carrying out artificial design synthesis of a site-directed mutagenesis primer, 2, carrying out site-directed mutagenesis of 98th and 104th basic groups of a hIL-29 mature peptide encoding gene by the site-directed mutagenesis primer, 3, constructing a recombinant eukaryotic expression vector containing a hIL-29 mutant encoding gene, and carrying out pichia pastoris transformation to obtain recombinant engineered yeast, 4, carrying out culture of the recombinant engineered yeast, and adding 1.5% (v/v) of methanol into the culture solution so that hIL-29 mutant expression is induced, and 5, through SP-Sepharose Fast Flow cation-exchange chromatography, carrying out purification of the hIL-29 mutant in the supernatant of the culture solution. The engineered yeast obtained by the invention can be subjected to high-density culture, can secrete and express the hIL-29Z with arginine and lysine produced respectively by site-directed mutagenesis of 33th lysine and 35th arginine, and is suitable for industrial preparation of hIL-29 mature peptide mutants.

The invention discloses an image synthesis method and device, equipment and an image carrier. The method comprises the following steps of: obtaining image data and forming a printable area; calling asynthesis material according to a user operation and obtaining configuration information of the synthesis material; and synthesizing the synthesis material to the printable area according to the configuration information so as to generate image synthesis data. According to the method, more convenient image edition environment is provided for users, so that memory occupation of terminal equipment is saved, synthesis effect pictures of image data and synthesis materials are drawn, and the designed synthesis effect pictures can be browsed in real time.

The invention describes a semi-automated method and system for Field Programmable Gate Array (FPGA) timing closure. The method is used to achieve timing closure by storing all previous results of design synthesis, place & route, tool options, and area constraints in a database, applying a set of analysis algorithms on the entire build history, and applying a decision engine to determine set of synthesis and place & route tool options and area constraints for the next build iteration. The aim of the inventive method is to eliminate most of the manual steps during design timing closure. The inventive method further makes the process faster, requiring fewer build iterations, and more robust to small design changes that can affect timing results. The desired outcome is achieved by making decisions based on the analysis of all the previous build results.