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Cefminox sodium drug composition and preparation method thereof

A technology of cefminox sodium and its composition, which is applied in the field of cefminox sodium pharmaceutical composition and its preparation, can solve the problems of strong toxic and side effects of metronidazole, large amount of metronidazole, etc., and achieve simple preparation process and ensure stability sexual effect

Inactive Publication Date: 2013-05-22
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Infections in clinical operations are often accompanied by mixed infections containing anaerobic bacteria and aerobic bacteria, rather than a single anaerobic or aerobic bacterial infection, because metronidazole is the clinical first choice for the treatment of anaerobic infection, Clinically, cefminox sodium and metronidazole are commonly used in combination to prevent surgical infection and treat complex infections containing anaerobic bacteria. However, both cefminox sodium for injection and metronidazole for injection are , the dosage of metronidazole is very large, and the toxic and side effects of metronidazole are very strong. Normal therapeutic doses of metronidazole can cause gastrointestinal reactions, the most common of which include nausea, vomiting, loss of appetite, abdominal cramps and high neurotoxicity

Method used

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  • Cefminox sodium drug composition and preparation method thereof
  • Cefminox sodium drug composition and preparation method thereof
  • Cefminox sodium drug composition and preparation method thereof

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Embodiment 1

[0033] Embodiment one, cefminox sodium composition powder for injection, in 1000 pieces

[0034] Prescription (specification: 0.5g / bottle):

[0035]

[0036] Preparation Process:

[0037] Add the prescribed amount of metronidazole lipid microspheres (calculated as metronidazole) directly to an appropriate amount of water for injection; stir and dissolve, then add a pH regulator to adjust the pH of the solution so that it is in the range of 6.5-6.8; 0.45μm and 0.22μm filter membranes are used for sterilization cycle filtration for 30 minutes; after the sampling inspection meets the requirements, the solution is divided into stainless steel trays, put into a freeze-drying box, and freeze-dried to obtain sterile freeze-dried metronidazole powder, pulverized and sieved; after mixing the pulverized and sieved metronidazole freeze-dried powder and cefminox sodium sterile powder, after the sampling inspection meets the requirements, subpackage according to the marked amount to ob...

Embodiment 2

[0038] Embodiment two, cefminox sodium composition powder for injection, in 1000 pieces

[0039] Prescription (specification: 1.0g / bottle):

[0040]

[0041] Preparation Process:

[0042] Add the prescribed amount of metronidazole lipid microspheres (calculated as metronidazole) directly to an appropriate amount of water for injection; stir and dissolve, then add a pH regulator to adjust the pH of the solution so that it is in the range of 6.5-6.8; 0.45μm and 0.22μm filter membranes are used for sterilization cycle filtration for 30 minutes; after the sampling inspection meets the requirements, the solution is divided into stainless steel trays, put into a freeze-drying box, and freeze-dried to obtain sterile freeze-dried metronidazole powder, pulverized and sieved; after mixing the pulverized and sieved metronidazole freeze-dried powder and cefminox sodium sterile powder, after the sampling inspection meets the requirements, subpackage according to the marked amount to ob...

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Abstract

The invention provides a cefminox sodium drug composition and a preparation method thereof, relating to the fields of pharmaceutical preparations and preparation methods and mainly solving the problems that single preparations of cefminox sodium and metronidazole in the prior art have great dosages, poor treatment effects after being combined and big side effects. The drug composition comprises cefminox sodium and metronidazole lipid microspheres in a weight ratio of (100:3)-(100:10), wherein the weight of the metronidazole lipid microspheres is based on metronidazole. The drug composition is prepared into powder injection. The pH value of water solution of the drug composition is 6.5-7.0. The powder injection of the drug composition provided by the invention not only has high curative effect but also can reduce the dosage of metronidazole by over 80%, thus greatly reducing or avoiding the toxic and side effects, especially gastrointestinal reactions including nausea, emesis, anorexia, abdominal cramp and neurotoxicity, of metronidazole and further reducing the occurrence rate of adverse reactions.

Description

Technical field: [0001] The invention relates to the field of pharmaceutical preparations and preparation methods, in particular to a cefminox sodium pharmaceutical composition and a preparation method thereof. Background technique: [0002] The chemical name of cefminox sodium is: (6R,7S)-7β-[(S)-2-[(2-amino-2-carboxyethyl)sulfur]acetamido]-7α-methoxy-3- [1-Methyl-1H-tetrazol-5-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. Molecular formula: C 16 h 20 N 7 NaO 7 S 3 , Molecular weight: 541.56. Its chemical structural formula is: [0003] [0004] Cefminox sodium not only plays a bactericidal effect on the bacterial proliferation stage, but also on the initial stage of the stable stage. Cefminox sodium is a cefamycin preparation that also shows bactericidal effect under the condition of inactivation of proliferation. It shows antibacterial effect on both the bacterial proliferation stage and the stable stage. Antimicrobial spe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K31/4164A61K9/14A61P31/04
CPCY02A50/30
Inventor 汪金灿汪六一
Owner HAINAN WEI KANG PHARMA QIANSHAN
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