The invention discloses a novel foam-filled honeycomb sandwich board, the structure of which comprises a pyramidal honeycomb core, rigid polyurethane foam and panels clamping both sides of the rigid polyurethane foam. Mould pressing, rolling and other methods are utilized to process a whole board/sheet into a latticed supporting body-shaped core board as the pyramidal honeycomb core with a series of staggered concave-convex truncated pyramids on both sides, a V-shaped groove can be formed at the joint between the slanted arrises of neighboring raised truncated pyramids, so that the notches of the truncated pyramids on the core board are communicated with one another, moreover, the vertex of each truncated pyramid body is a small plane, so that the panels on both sides can be conveniently bonded, and the rigid polyurethane foam plastic is filled in the clearance of the pyramidal honeycomb core between the panels on both sides. The produced novel foam-filled honeycomb sandwich board has all the advantages of the honeycomb sandwich board and the foam sandwich board, and is a novel composite-structured board with the advantages of reasonable structure, excellent performance, light weight, high strength and simple and easy production technique, which can be widely applied in various fields such as aeronautics and aerospace, vehicles, ships, furniture and buildings.