The invention discloses a distributed control system (DCS) frame for a nuclear power reactor. The frame includes a safety-level DCS and a non-safety-level DCS; the non-safety-level DCS includes a non-safety-level monitoring device, a monitoring network, a non-safety-level gateway, a real-time server, a system network, a first control station, a diversified drive system and the like on an operationstation, wherein the non-safety-level monitoring device, the monitoring network, the real-time server, the system network and the first control station are connected in sequence; and the safety-levelDCS includes a plurality of protection groups, a specially-arranged safety facility drive cabinet, a data transmission cabinet, a safety-level bus, a safety-level gateway, a device interface cabinet,a safety-level monitoring device on a backup disk and the like, wherein the safety-level bus, the safety-level gateway, the non-safety-level gateway and the monitoring network are connected in sequence. By implementing the frame, a compact layout scheme of a main control room can be constructed on the premise of ensuring the basic functions of the main control room.