The present invention discloses a fireproof, explosion-proof and earthquake-resistant multi-purpose safety warehouse, comprising a warehouse body and two side blocks, wherein the side blocks are fixedly connected with a sliding sleeve, the sliding sleeve is sealingly and slidingly connected with a connecting block, the connecting block is fixedly connected with the side wall of the warehouse body through a quick-release bolt, the upper surface of the side block is fixedly connected with a vertical block, a shock absorbing mechanism is arranged in the vertical block, the side block is provided with two sliding grooves, the side block is sealingly and slidingly connected with two sliders through the sliding groove, the lower surface of the slider is provided with a fixing mechanism, the fixing mechanism comprises a screw, the screw is rotatably connected with the lower surface of the slider through a bearing, and the screw is provided with an installation groove. The advantages are: the installation and disassembly of the safety warehouse of the present invention are more convenient, and it has a good earthquake-resistant function, effectively ensuring that the internal materials are protected to a certain extent during the vibration process, and further improving the safety of the safety warehouse.