Pullulan polysaccharide hollow hard capasule and its preparing method

A technology of pullulan polysaccharide and hollow hard capsules, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of hollow capsules such as unstable quality, poor appearance, and surface fogging, and achieve Broad market prospects and practical value, stable disintegration index, and the effect of not being easily hydrolyzed

Inactive Publication Date: 2007-11-14
广东强基药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the quality of hollow capsules made of water-soluble cellulose derivatives as the main raw material is still unstable, especially in the disintegration of the gastrointestinal tract, and after a certain period of time, chemical substances are precipitated from the capsule shell, and the surface is fogged, appearing Yellowing, poor appearance and shape

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Get average molecular weight 200,000, 10 kilograms (containing 6wt% moisture) of the pullulan polysaccharide that obtains by ethanol dehydration, decolorization and desalination, join in 65 kilograms of pure waters, soak 1 hour, stir and be heated to 80 ℃, wait for Pululan After Lulan polysaccharide is completely dissolved, add 350 grams of carrageenan, 5 grams of sodium lauryl sulfonate, and 5 grams of glycerin, and then add 75 grams of potassium chloride after dissolving, and filter with a 100-mesh filter after uniform dissolution.

[0023] After removing air bubbles, it is dipped in glue on automatic capsule production equipment, dried at 40°C, and then demolded. After trimming, fitting, and inspection, it becomes a transparent hollow hard capsule. The prepared hollow hard capsules can be used as hollow capsules after testing, can contain solid materials, and can also be filled with oily liquid, semi-solid or pasty materials.

Embodiment 2

[0025] Get average molecular weight 300,000, 10 kilograms (containing 8wt% moisture) of pullulan obtained after ethanol dehydration, decolorization and desalination, 200 grams of pectin, 10 grams of Span-20, 20 grams of simethicone and 40 grams of lemon Potassium acid potassium was added to 70 kg of pure water, heated to 90°C with stirring, and filtered with a 100-mesh filter after uniform dissolution.

[0026] After removing air bubbles, it is dipped in glue on the automatic capsule production equipment, dried at 40°C, and then demoulded, trimmed, fitted, and inspected to become a transparent hollow hard capsule. The prepared hollow hard capsules can be used as hollow capsules after testing, can contain solid materials, and can also be filled with oily liquid, semi-solid or pasty materials.

Embodiment 3

[0028] Get average molecular weight 100,000, 10 kilograms (containing 8wt% moisture) of the pullulan polysaccharide that obtains by ethanol dehydration, decolorization and desalination, join in 70 kilograms of pure waters, heat to 75 ℃ under stirring, until pullulan polysaccharide is completely After dissolving, add 250 grams of agar, 10 grams of Tween 80, 15 grams of castor oil, 40 grams of calcium chloride, 100 grams of 300 mesh titanium dioxide powder, and an appropriate amount of food coloring agent. After uniform dissolution, filter with a 100-mesh filter.

[0029] After removing air bubbles, it is dipped in glue on automatic capsule production equipment, dried at 40°C, and then demoulded, trimmed, fitted, and inspected to become a dyed opaque hollow hard capsule. The prepared hollow hard capsules can be used as hollow capsules after testing, can contain solid materials, and can also be filled with oily liquid, semi-solid or pasty materials.

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PUM

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Abstract

The present invention discloses a hollow hard capsule and its preparation method. It is made up by adopting prolanpolysaccharide as main body material and adding gelling agent, coagulant aids, surfactant and humectant through a certain preparation process. Said invention also provides the concrete steps of its preparation method.

Description

technical field [0001] The invention relates to a hollow hard capsule for containing medicine or food and a manufacturing method thereof. Background technique [0002] Hollow hard capsules have been widely used as drug or food packaging carriers. At present, there are three main types: [0003] One type is widely used gelatin capsules, which are made from gelatin extracted from animal skins and bones together with some plasticizers, sunscreens, and pigments. fear that animal protein is a safety hazard, and some religions have always resisted animal products. In addition, gelatin capsules are sensitive to changes in temperature and humidity, and are easily hydrolyzed, denatured, and broken when the temperature and humidity are improper. Therefore, gelatin capsules are constantly rejected by various parties. [0004] The other type is vegetable starch capsules, which are made of vegetable starch or starch derivatives with certain plasticizers. Starch empty capsules disclose...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/34A61K47/36A61J3/07
Inventor 李煜龙许锐鹏李桂龙陈坤昭许舜金许雄群王春龙李加海
Owner 广东强基药业有限公司
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