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Pulullan soft capsule and preparation method thereof

A pullulan polysaccharide and soft capsule technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and inactive medical preparations, can solve problems such as restricting the popularization and application of soft capsule products, easily causing pollution, etc., and achieves broad market prospects and Practical value, easy control of product quality, and non-brittle effect

Active Publication Date: 2014-08-06
SHANDONG MEICHEN ECOLOGY & ENVIRONMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gelatin is an animal protein colloid, and contains a certain amount of animal fat. Generally, the animal fat content in gelatin is about 2.2%, which is easy to cause pollution (foot-and-mouth disease, mad cow disease, etc.), these shortcomings restrict the popularization and application of soft capsule products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] First, prepare the following raw materials: 2000 g of pullulan, 200 g of welan gum, 1500 g of glycerol, 2 g of sophorolipid, 3 g of calcium propionate, and 6500 g of water.

[0024] Then, prepare capsules according to the following steps: (1) add 6300g of water into a heating and stirring tank that can be evacuated, and let the mixer run at a speed of 50 rev / min; (2) add 2000g of pullulan, 200g of welan gum, 1500g of glycerol, 2g of sophorolipid, and 3g of calcium propionate were put into the tank respectively. After feeding, the stirring speed was adjusted to 80 rpm, and each component was stirred until it was evenly mixed and completely dissolved; (3) Turn on the heating switch and set the The temperature in the tank was raised to 60°C and kept for 0.5h; (4) Stir at a speed of 30 rpm, while vacuuming to eliminate air bubbles in the glue solution; (5) The glue solution was made into a long strip of film with a mold; (6) ) Put the film at 75° C., in an environment with ...

Embodiment 2

[0026] First, prepare the following raw materials: 6000 g of pullulan, 200 g of welan gum, 1500 g of glycerin, 80 g of sophorolipids, 30 g of calcium propionate, and 2500 g of water.

[0027] Then, prepare capsules according to the following steps: (1) add 2200 g of water into a heating and stirring tank that can be evacuated, and let the mixer run at a speed of 30 rev / min; (2) add 6000 g of pullulan, 200 g of welan gum, 1500g of glycerol, 80g of sophorolipid, and 30g of calcium propionate were put into the tank respectively. After feeding, the stirring speed was adjusted to 50 rpm, and each component was stirred until it was evenly mixed and completely dissolved; (3) Turn on the heating switch and set the The temperature in the tank was raised to 75°C and kept for 3 hours; (4) Stir at a speed of 30 rpm, while vacuuming to eliminate air bubbles in the glue solution; (5) The glue solution was made into a long strip of film with a mold; (6) The film was left to stand at 35° C. a...

Embodiment 3

[0029] First, prepare the following raw materials: 4000 g of pullulan, 15 g of welan gum, 3000 g of glycerol, 60 g of sophorolipids, 10 g of calcium propionate, and 3000 g of water.

[0030] Then, prepare capsules according to the following steps: (1) add 3000g of water into a heating and stirring tank that can be evacuated, and let the mixer run at a speed of 30 rev / min; (2) add 4000g of pullulan, 15g of welan gum, 3000g of glycerol, 60g of sophorolipids, and 10g of calcium propionate were put into the tank respectively. After feeding, the stirring speed was adjusted to 50 rpm, and the components were stirred until they were evenly mixed and completely dissolved; (3) Turn on the heating switch and set the The temperature in the tank was raised to 95°C and kept for 1 hour; (4) Stir at a speed of 30 rpm, while vacuuming to eliminate air bubbles in the glue solution; (5) The glue solution was made into a long strip of film with a mold; (6) The film was left to stand at 55° C. an...

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Abstract

The invention discloses a Pulullan soft capsule and a preparation method thereof. The Pulullan soft capsule is prepared from the following components in percentage by weight: 20-60% of Pulullan, 0.15-2% of gelatinizer, 15-30% of plasticizer, 0.02-0.8% of emulsifier, 0.03-0.3% of cosolvent and 22-63% of water. The Pulullan soft capsule has the advantages of higher oxygen barrier property, higher shock strength, stable quality, low tendency to crushing, stable disintegration index and low tendency to hydrolysis, and can not easily produce fog or become yellow on the surface after long-time placement. The raw materials are from pure plants, thereby completely avoiding pollutions which can be caused by animal proteins. The capsule has lower water content than the gelatine capsule, is more suitable for filling hydroscopic drugs and aldehyde-containing drugs, and has wide market prospects and practical value.

Description

technical field [0001] The invention relates to the technical field of capsules, in particular to a pullulan soft capsule with pullulan as a main raw material and a preparation method of the soft capsule. Background technique [0002] Soft capsule is a new type of capsule developed in the fields of medicine, food, health care products, cosmetics, etc. in recent years. It is a quantitative injection of the packaged material and encapsulated in the rubber to form a sealed capsule, with accurate and uniform content. Good performance, beautiful appearance and so on. [0003] But as the rubber of soft capsules, gelatin is basically used as the main ingredient gelling agent at present. The water content of hard capsules made of gelatin has a certain range (12.5% ​​to 17.5%). If it is lower than this range, the friability of the capsules will increase, which is not conducive to the filling of drugs. For hygroscopic drugs (some Chinese herbal medicines) ), the moisture in the caps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/715A61K47/26
Inventor 张磊
Owner SHANDONG MEICHEN ECOLOGY & ENVIRONMENT CO LTD
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