Pulullan polysaccharide empty hard capsule and preparation method thereof

Abstract

The invention discloses a polullan polysaccharide empty hard capsule and a preparation method thereof. The preparation method comprises the following steps: mainly adopting polullan polysaccharide, gel agent, plasticizer, emulsifying agent, latent solvent, water, and the like as raw materials; stirring and dissolving the raw materials in a heating-stirring tank which is vacuumized, heating to formglue, filtering, conveying glue solution into a capsule making machine for making a capsule and finally obtaining the polullan polysaccharide empty hard capsule. The empty hard capsule has the advantages of good quality stability, uneasy friability, stable breakdown index, difficult hydrolysis, no misty and yellowing appearance on the surface while in long-term deposition and can hold solids, oily liquid, semisolids and pasty materials; especially, as the water content of the capsule is lower than that of a gelatine capsule, the capsule is more suitable for being filled with moisture-absorption medicines and aldehydes-containing medicines and has wide market prospect and practical value.

Description

technical field [0001] The invention relates to the technical field of capsules, in particular to a pullulan hollow hard capsule with pullulan as the main raw material, and also relates to a preparation method of the hard capsule. Background technique [0002] Hollow hard capsule is a new dosage form developed in the fields of medicine, food, health care products, chemical products, etc. in recent years. , good uniformity, beautiful appearance and so on. [0003] However, as the rubber of hollow hard capsules, gelatin is basically used as the main gelling agent at present, and the water content of hard capsules prepared from gelatin has a certain range (12.5% ​​to 17.5%). The friability of the capsule increases, which is not conducive to drug filling. For hygroscopic drugs (some Chinese herbal medicines), the moisture in the capsule is easily absorbed by the filling, and the filled drug capsules are easy to crack during storage; Stable medicine also affects the validity pe...

AI Technical Summary

Problems solved by technology

[0003] However, as the rubber of hollow hard capsules, gelatin is basically used as the main gelling agent at present, and the water content of hard capsules prepared from gelatin has a certain range (12.5% ​​to 17.5%). The friability of the capsule increases, which is not conducive to drug filling. For hygroscopic drugs (some Chinese herbal medicines), the moisture in the capsule is easily absorbed by the filling, and the filled drug capsules are easy to crack during storage; Stable drugs also affect the expiration date of the drug. Gelatin is prone to aldehyde drug reactions, producing insoluble substances, prolonging the disintegration time of the capsule, and changing the color of the capsule

[0004] Hollow capsules and capsule medicines made of gelatin should be stored in a constant temperature and humidity environment. Because the temperature is too high, the capsules are easy to soften and deform, and the temperature is too low, the capsules are easy to crack. Store gelatin hard capsules at 0°C for three months. Unqualified friability

Gelatin is an animal protein colloid and contains certain animal fat. Generally, the animal fat content in gelatin is about 2.2%, which is easy to cause pollution (foot-and-mouth disease, mad cow disease, etc.), these shortcomings restrict the popularization and application of hollow hard capsule products