6 results about "Surface plasmon resonance sensor" patented technology

The invention discloses an immune quantitative detection device for tumor markers, relates to the technical field of medical detection, and aims to solve the problems of complicated operation, long detection period and poor portability in immune quantitative detection of tumor markers in the prior art. Comprising a shell, a disposable detection card, a multi-channel micro-fluidic chip, a high-sensitivity sensing system, a micro magnetic control incubation module, an AI auxiliary image recognition system and a wireless transmission module, the disposable detection card is used for accommodating the multi-channel micro-fluidic chip and a reaction reagent, and the multi-channel micro-fluidic chip is respectively aligned with the high-sensitivity sensing system and the micro magnetic control incubation module; the high-sensitivity sensing system is composed of a surface plasma resonance sensor and a quantum dot fluorescence labeling module, and the surface of a sensing chip of the surface plasma resonance sensor is modified with a tumor marker specific capture antibody. The method has the advantages of convenient detection and high efficiency and precision.

The invention relates to the field of optical fiber sensing, in particular to a multichannel optical fiber surface plasma resonance sensing probe as well as a preparation method and application thereof. According to the multichannel optical fiber surface plasma resonance sensing probe, the sensing probe adopts an end face reflection type optical fiber sensing structure, and the end face reflection type structure is formed by welding a multimode optical fiber and a coreless optical fiber. A multimode-coreless optical fiber welded end face reflection type structure is adopted, SPR signals are excited through end face total reflection, the defect that a traditional lateral coupling type optical fiber SPR sensor is difficult to carry out directional detection in narrow spaces (such as blood vessels and tissue gaps) is overcome, miniaturized insertion type diagnosis with the minimum diameter being 300 micrometers is achieved, and the SPR sensor is suitable for in-situ monitoring of living tissue; according to the invention, through the nanocluster modification layers (0 / 2 / 4 layers) which are axially distributed at intervals, multi-channel functionalization can be completed only by a pulling method, traditional micro-nano processing and a complex film layer structure are not needed, and the preparation time of the multi-channel sensor is shortened from gt to gt; and the time is shortened from 6 hours to 1 hour.

To provide a surface plasmon resonance sensor capable of obtaining a clear surface plasmon resonance response. [Solution] The surface plasmon resonance sensor comprises a substrate having a first surface and a second surface opposite to the first surface, a metal film provided on the first surface of the substrate and having a sample placement area on a third surface opposite to the first surface where a sample is placed, and being irradiated with light from the second surface side through the substrate, and a diffraction grating provided on the first surface or the second surface, such that at least a part of it overlaps with at least a part of the sample placement area when viewed in the thickness direction of the substrate, wherein the thickness of the substrate between the first surface and the second surface is t, and the refractive index of the substrate at the wavelength of the light is n, then t / n is 2 μm or less.

The invention belongs to the technical field of sensors, and particularly relates to a surface plasmon resonance sensor based on a molecularly imprinted polymer and a preparation method of the surface plasmon resonance sensor. The preparation method comprises the following steps: preparing an SPR chip with an Au / Cr / cover glass structure by adopting a magnetron sputtering method; then polydopamine is electrically polymerized on the surface to form a PDA / Au / Cr / cover glass structure; the preparation method comprises the following steps: preparing a dextromethorphan molecularly imprinted polymer (DXM-MIP) by taking p-mercaptophenol as a functional monomer and dextromethorphan as a template molecule through an electropolymerization method to form a DXM-MIP / PDA / Au / Cr / cover glass structure, and finally eluting the template molecule to obtain the surface plasmon resonance sensor (DXM-MIP / SPR sensor) based on the molecularly imprinted polymer. The DXM-MIP / SPR sensor is suitable for high-selectivity, wide-range, efficient and low-cost detection of dextromethorphan, and is especially suitable for qualitative and quantitative detection of dextromethorphan in drugs.

This invention provides a surface plasmon resonance sensor and its applications, relating to the field of microwave sensor technology. The surface plasmon resonance sensor of this invention includes a dielectric substrate, a metallic waveguide, and a subwavelength resonator, wherein the subwavelength resonator has a fan-shaped defect structure. By introducing an asymmetric loss structure through the design of the subwavelength resonator with the fan-shaped defect structure, the surface plasmon resonance sensor of this invention achieves a singularity state, exhibiting a square-root-dependent high sensitivity response to external perturbations. This significantly improves detection sensitivity and enables high sensitivity and low detection limits for substances such as deionized water, glycerol solution, and glucose solution, as well as dynamic detection of the hydrolysis process of thioacetylcholine. It has advantages such as simple structure, easy integration, and high sensitivity.

This invention belongs to the field of sensor technology, specifically relating to a surface plasmon resonance sensor based on molecularly imprinted polymers and its fabrication method. The invention employs magnetron sputtering to fabricate an Au / Cr / cover glass structure SPR chip; then, polydopamine is electropolymerized on the surface to form a PDA / Au / Cr / cover glass structure; next, using p-mercaptophenol as a functional monomer and dextromethorphan as a template molecule, a dextromethorphan molecularly imprinted polymer (DXM-MIP) is prepared by electropolymerization, forming a DXM-MIP / PDA / Au / Cr / cover glass structure. Finally, the template molecule is eluted to obtain a surface plasmon resonance sensor based on molecularly imprinted polymers (DXM-MIP / SPR sensor). The DXM-MIP / SPR sensor is suitable for the highly selective, wide-range, efficient, and low-cost detection of dextromethorphan, especially for the qualitative and quantitative detection of dextromethorphan in pharmaceuticals.